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Mostrando ítems 1-20 de 23
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An oral salmonella-based vaccine inhibits liver metastases by promoting tumor-specific T-cell-mediated immunity in celiac and portal lymph nodes : a preclinical study
(2016)Primary tumor excision is one of the most widely used therapies of cancer. However, the risk of metastases development still exists following tumor resection. The liver is a common site of metastatic disease for numerous ... -
Analysing nonsynonymous mutations between two Mycobacterium bovis strains with contrasting pathogenic profiles
(Elsevier, 2019-12)Mycobacterium bovis (M. bovis) is the causative agent of bovine tuberculosis, a chronic infectious disease that can affect cattle, other domesticated species, wild animals and humans. This disease produces important economic ... -
Deletion of A44L, A46R and C12L vaccinia virus genes from the MVA genome improved the vector immunogenicity by modifying the innate immune response generating enhanced and optimized specific T-Cell responses
(2016-05)MVA is an attenuated vector that still retains immunomodulatory genes. We have previously reported its optimization after deleting the C12L gene, coding for the IL-18 binding-protein. Here, we analyzed the immunogenicity ... -
Desarrollo de candidatos vacunales contra Babesia bovis basados en vectores virales y proteínas recombinantes
(Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 2016-09)La babesiosis bovina es una enfermedad parasitaria trasmitida por garrapatas y causada por los protozooarios intraeritrocíticos Babesia bovis y B. bigemina. Esta infección provoca importantes pérdidas económicas en varias ... -
Desarrollo y evaluación de un candidato vacunal para IBD producido en plantas: una alternativa a las vacunas tradicionales
(Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 2018)El Virus de la enfermedad infecciosa de la bursa (IBDV) es el agente etiológico responsable de una enfermedad aguda contagiosa e inmunosupresora que afecta pollos jóvenes y causa importantes pérdidas económicas. La vacunación ... -
Developments in plant-based vaccines against diseases of concern in developing countries
(BENTHAM Open, 2010)Vaccination has been extensively used to prevent, eradicate and control infectious diseases. However, the development and implementation of new vaccines remains prohibitively expensive for middle and low income countries where ... -
Double-layered rotavirus-like particles are efficient carriers to elicit strong CTL responses to delivered heterologous antigens
(Elsevier, 2014-11)The first 92 amino acids of VP2 of rotavirus are dispensable for VLP assembly and can be replaced by heterologous reporter proteins without affecting either self-assembly of chimeric VP2 or the interaction with VP6 to ... -
Editorial : Vaccination strategies against ruminant infectious diseases
(Frontiers Media, 2023-05)Ruminant infectious diseases cause economic impact through losses in animal production and human health. Most of the commercially available veterinary vaccines are live attenuated or inactivated which induce different ... -
Enterohemorrhagic Escherichia coli O157:H7 antigens produced in transgenic lettuce effective as an oral vaccine in mice
(Springer, 2023-10)Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a food-borne pathogen where ruminant farm animals, mainly bovine, serve as reservoirs. Bovine vaccination has been used to prevent disease outbreaks, and the current ... -
Estudio de la relación del virus de la Bursitis Infecciosa con su hospedador. Análisis de la respuesta inmune y de la función y localización de la proteína viral VP5
(Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 2015)Las aves representan un eslabón fundamental en la economía internacional. A nivel mundial, alrededor del 40% de la carne consumida es de origen aviar. La industria avícola ha experimentado en los últimos años un crecimiento ... -
Estudios genómicos y funcionales en Anaplasma marginale y en bacterias intracelulares de la clase alfa-proteobacteria y su relación con la reducción del genoma
(Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 2013)La subdivisión α- de la clase proteobacteria representa un grupo sumamente diverso y heterogéneo de bacterias con una gran variabilidad en sus características genómicas, biológicas y ecológicas. Dentro de esta subdivisión ... -
Evaluation of a virulent strain of Mycobacterium avium subsp. Paratuberculosis used as a heat-killed vaccine
(Elsevier, 2021-11)Bovine paratuberculosis is one of the most important chronic infectious diseases in livestock. This disease is difficult to control because of its inefficient management (test and cull strategy and inadequate biosecurity). ... -
Evaluation of different heterologous prime-boost immunization strategies against Babesia bovis using viral vectored and protein-adjuvant vaccines based on a chimeric multi-antigen
(2016)Protection against the intraerythrocytic bovine parasite Babesia bovis requires both humoral and cellular immune responses. Therefore, tailored combinations of immunogens targeted at both arms of the immune system are ... -
Immunogenicity of hypothetical highly conserved proteins as novel antigens in Anaplasma marginale
(Springer, 2014-03)Anaplasma marginale is a tick-transmitted Gram-negative intraerythrocytic bacterium and the etiological agent of bovine Anaplasmosis. Even though considerable research efforts have been undertaken, Anaplasmosis vaccine ... -
MVAΔ008 viral vector encoding the model protein OVA induces improved immune response against the heterologous antigen and equal levels of protection in a mice tumor model than the conventional MVA
(Elsevier, 2021-11)Modified vaccinia Ankara virus (MVA) is extensively used as a vaccine vector. We have previously observed that MVAΔ008, an MVA lacking the gene that codes for interleukin-18 binding protein, significantly increases CD8+ ... -
Obtención de mutantes de Brucella abortus genéticamente definidas: su caracteización molecular y evaluación de su uso como vacunas para la brucelosis bovina
(Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 2017)El desarrollo de las técnicas de ADN recombinante permitió la generación de vacunas racionalmente diseñadas. Teniendo esto en cuenta, el objetivo de este trabajo es la obtención de cepas de Brucella abortus genéticamente ... -
Plant-based vaccine candidate against Infectious bursal disease: an alternative to inactivated vaccines for breeder hens
(Elsevier, 2019-08)Infectious bursal disease (IBD) is an acute, highly contagious immunosuppressive disease that affects young birds causing important economic losses in the poultry industry worldwide. Strict hygiene management together with ... -
Protection efficacy of Argentinian isolates of Mycobacterium avium subsp. paratuberculosis with different genotypes and virulence in a murine model
(Elsevier, 2018-12)Paratuberculosis is a chronic disease caused by Mycobacterium avium subsp. paratuberculosis (Map). The disease causes economic losses and, therefore, it is imperative to follow proper control strategies, which should include ... -
Systemic administration of imiquimod as an adjuvant improves immunogenicity of a tumor-lysate vaccine inducing the rejection of a highly aggressive T-cell lymphoma
(Elsevier, 2019-06)T-cell lymphomas include diverse malignancies. They are rare, some have low survival rates and they lack curative therapies. The aim of this work was to assess whether employing the TLR7 agonist imiquimod and the T-cell ... -
The subunit vaccine H65 + CAF01 increased the BCG- protection against Mycobacterium bovis infection in a mouse model of bovine tuberculosis
(Elsevier, 2021-05)H65, a fusion protein of three pairs of ESX-secreted antigens of Mycobacterium tuberculosis and Mycobacterium bovis, formulated with the liposomal adjuvant CAF01 has been shown to confer protection against M. tuberculosis ...