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An inhibitory mechanism of action of coiled‐coil peptides against type three secretion system from enteropathogenic Escherichia coli
(Wiley, 2019-03)Human pathogenic gram‐negative bacteria, such as enteropathogenic Escherichia coli (EPEC), rely on type III secretion systems (T3SS) to translocate virulence factors directly into host cells. The coiled‐coil domains present ... -
Characterization of Escherichia coli carrying mcr-1-plasmids recovered from food animals from Argentina
(Frontiers Media, 2019-03)In this study, we found mcr-1.1 and mcr-1.5 genes carried by IncI2 plasmids in a subset of Escherichia coli isolates recovered from commercial broiler farms in Argentina. The comparative analysis of the sequences of these ... -
Early immune innate hallmarks and microbiome changes across the gut during Escherichia coli O157: H7 infection in cattle
(SpringerNature, 2020-12)The zoonotic enterohemorrhagic Escherichia coli (EHEC) O157: H7 bacterium causes diarrhea, hemorrhagic colitis, and hemolytic uremic syndrome (HUS) in humans. Cattle are primary reservoirs and EHEC O157: H7; the bacteria ... -
Efficacy of a recombinant Intimin, EspB and Shiga toxin 2B vaccine in calves experimentally challenged with Escherichia coli O157:H7
(Elsevier, 2018-06)Escherichia coli O157:H7 is a zoonotic pathogen of global importance and the serotype of Shiga toxin-producing E. coli (STEC) most frequently associated with Hemolytic Uremic Syndrome (HUS) in humans. The main STEC reservoir ... -
Enterohemorrhagic Escherichia coli O157:H7 antigens produced in transgenic lettuce effective as an oral vaccine in mice
(Springer, 2023-10)Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a food-borne pathogen where ruminant farm animals, mainly bovine, serve as reservoirs. Bovine vaccination has been used to prevent disease outbreaks, and the current ... -
Epidemiological characterization of isolates of Salmonella enterica and shiga toxin-producing Escherichia coli from backyard production system animals in the Valparaíso and metropolitana regions
(MDPI, 2023-08)Backyard production systems (BPS) are distributed worldwide, rearing animals recognized as reservoirs of Salmonella enterica and Shiga toxin-producing Escherichia coli (STEC), both zoonotic pathogens. The aim of this study ... -
Estudio y evaluación de la dinámica de resistencia a cefalosporinas y fluoroquinolonas en Salmonella spp. y Escherichia coli en animales de producción
(Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, 2016)El alarmante incremento de la resistencia bacteriana a los antimicrobianos (ATM) es sin duda, uno de los mayores problemas actuales de la salud pública. Estos compuestos constituyen una de las principales herramientas para ... -
Evaluación de proteínas de una isla de patogenicidad y de envolturas bacterianas de Escherichia coli 0157:H7 como vacunas para reducir su incidencia en bovinos
(Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, 2015-11)Escherichia coli enterohemorrágico (EHEC) es un patógeno que puede causar diarrea, colitis hemorrágica, y síndrome urémico hemolítico (SUH), una enfermedad sistémica grave que afecta principalmente a los niños. En Argentina ... -
The intranasal vaccination of pregnant dams with Intimin and EspBconfers protection in neonatal mice from Escherichia coli (EHEC)O157:H7 infection
(2016-05)Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is responsible for intestinal disease and hemolytic uremic syndrome (HUS), a serious systemic complication which particularly affects children. In this study, we evaluated ... -
Physiopathological effects of Escherichia coli O157:H7 inoculation in weaned calves fed with colostrum containing antibodies to EspB and Intimin
(Elsevier, 2014-06-24)Escherichia coli O157:H7 is responsible for severe intestinal disease and hemolytic uremic syndrome (HUS), a serious systemic complication which particularly affects children. Cattle are the primary reservoir for E. coli ... -
Preservation of protective capacity of hyperimmune anti-Stx2 bovine colostrum against enterohemorrhagic Escherichia coli O157:H7 pathogenicity after pasteurization and spray-drying processes
(Elsevier, 2021-05)Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a major etiologic agent that causes bloody diarrhea, hemorrhagic colitis, and hemolytic uremic syndrome (HUS). Shiga toxin (Stx) is the main virulence factor of EHEC ... -
Simultaneous carriage of mcr-1 and other antimicrobial resistance determinants in Escherichia coli from poultry
(Frontiers Media, 2018-07)The use of antimicrobial growth promoters (AGPs) in sub-therapeutic doses for long periods promotes the selection of resistant microorganisms and the subsequent risk of spreading this resistance to the human population and ... -
The role of glucose in the pathology of EHEC O157: H7
(Cambridge University Press, 2020-04)The pathogen enterohemorrhagic Escherichia coli (EHEC) O157: H7 is responsible for hemorrhagic colitis and hemolytic uremic syndrome in humans [1]. During the colonization process in the gastrointestinal tract, EHEC needs ...