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Nothofagus antarctica (NA) is a native tree of Patagonia. Since ancient times, NA leaves were used in infusions for medical and food purposes, but there are no deep insights on its toxicity. The aim of this work was to assess the safety and antioxidant activity of NA leaves infusion. Mice were used to determine acute and subacute oral toxicity. Total polyphenols, flavonoids and the antioxidant activity of the infusion were assessed, as well as the
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dc.contributor.author | Hugo, Ayelén A. | |
dc.contributor.author | Serradell, María De los Ángeles | |
dc.contributor.author | Peri, Pablo Luis | |
dc.contributor.author | Farina, Sebastián | |
dc.contributor.author | Gomez-Zavaglia, Andrea | |
dc.date.accessioned | 2024-02-28T11:49:16Z | |
dc.date.available | 2024-02-28T11:49:16Z | |
dc.date.issued | 2024-01-04 | |
dc.identifier.citation | Hugo A.A.; Serradell M.A.; Peri P.L.; Farina S.; Gómez-Zavaglia A. (2024) In vivo oral toxicity and antioxidant capacity of Nothofagus antarctica (G.Forst.) oerst (ñire) leaves. CyTA-Journal of Food 22(1): e2298569. https://doi.org/10.1080/19476337.2023.2298569 | es_AR |
dc.identifier.issn | 1947-6345 (Online) | |
dc.identifier.issn | 1947-6337 (print) | |
dc.identifier.other | https://doi.org/10.1080/19476337.2023.2298569 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12123/16818 | |
dc.identifier.uri | https://www.tandfonline.com/doi/full/10.1080/19476337.2023.2298569 | |
dc.description.abstract | Nothofagus antarctica (NA) is a native tree of Patagonia. Since ancient times, NA leaves were used in infusions for medical and food purposes, but there are no deep insights on its toxicity. The aim of this work was to assess the safety and antioxidant activity of NA leaves infusion. Mice were used to determine acute and subacute oral toxicity. Total polyphenols, flavonoids and the antioxidant activity of the infusion were assessed, as well as the antioxidant activity in biological samples. Toxicity tests revealed no death or signs of toxicity. No significant differences in biochemical parameters/histological structure were registered. NA infusion exhibited a high content of polyphenols and flavonoids, contributing to its remarkably antioxidant activity. The periodic administration of NA infusion could increase the antioxidant capacity in mice at intestinal level. The results support the safe of consuming NA leaves infusion and suggest their contribution for modulating the intestinal oxidative stress. | eng |
dc.format | application/pdf | es_AR |
dc.language.iso | eng | es_AR |
dc.publisher | Taylor & Francis Group | es_AR |
dc.rights | info:eu-repo/semantics/openAccess | es_AR |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | es_AR |
dc.source | CyTA-Journal of Food 22 (1) : e2298569. (January 2024) | es_AR |
dc.subject | Nothofagus | es_AR |
dc.subject | Primary Forests | eng |
dc.subject | Bosques Primarios | es_AR |
dc.subject | Uso Múltiple | es_AR |
dc.subject | Multiple Use | eng |
dc.subject | Hojas | es_AR |
dc.subject | Leaves | eng |
dc.subject | Infusión | es_AR |
dc.subject | Infusion | eng |
dc.subject | Antioxidant Properties | eng |
dc.subject | Propiedades Antioxidantes | es_AR |
dc.subject | Toxicity | eng |
dc.subject | Toxicidad | es_AR |
dc.subject | Mice | eng |
dc.subject | Ratones | es_AR |
dc.subject | Polyphenols | eng |
dc.subject | Polifenoles | es_AR |
dc.subject | Flavonoids | eng |
dc.subject | Flavonoides | es_AR |
dc.subject | Toxicity Tests | eng |
dc.subject | Ensayos de Toxicidad | es_AR |
dc.subject | Histopathology | eng |
dc.subject | Histopatología | es_AR |
dc.subject.other | Antioxidant Activity | eng |
dc.subject.other | Actividad Antioxidante | es_AR |
dc.subject.other | Ñire | es_AR |
dc.subject.other | Nothofagus antarctica | es_AR |
dc.subject.other | Animal Model | eng |
dc.subject.other | Modelo Animal | es_AR |
dc.subject.other | Biological Samples | eng |
dc.subject.other | Muestras Biológicas | es_AR |
dc.subject.other | Plasma Biochemistry | eng |
dc.subject.other | Bioquímica Plasmática | es_AR |
dc.subject.other | Antioxidant Capacity | eng |
dc.subject.other | Capacidad Antioxidante | es_AR |
dc.subject.other | Región Patagónica | es_AR |
dc.title | In vivo oral toxicity and antioxidant capacity of Nothofagus antarctica (G.Forst.) oerst (ñire) leaves | es_AR |
dc.type | info:ar-repo/semantics/artículo | es_AR |
dc.type | info:eu-repo/semantics/article | es_AR |
dc.type | info:eu-repo/semantics/publishedVersion | es_AR |
dc.rights.license | Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) | es_AR |
dc.description.origen | EEA Santa Cruz | es_AR |
dc.description.fil | Fil: Hugo, Ayelén A. Center for Research and Development in Food Cryotechnology (CIDCA, CCT-CONICET La Plata); Argentina. | es_AR |
dc.description.fil | Fil: Serradell, María De los Ángeles. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Microbiología; Argentina. | es_AR |
dc.description.fil | Fil: Peri, Pablo Luis. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Santa Cruz; Argentina. | es_AR |
dc.description.fil | Fil: Peri, Pablo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. | es_AR |
dc.description.fil | Fil: Peri, Pablo Luis. Universidad Nacional de la Patagonia Austral; Argentina. | es_AR |
dc.description.fil | Fil: Farina, Sebastián. Gobierno de Tierra del Fuego, Antártida e Islas del Atlántico Sur. Ministerio de Producción y Ambiente. Secretaría de Desarrollo Productivo y PyME. Dirección General de Desarrollo Forestal; Argentina. | es_AR |
dc.description.fil | Fil: Gomez-Zavaglia, Andrea. Center for Research and Development in Food Cryotechnology (CIDCA, CCT-CONICET La Plata); Argentina. | es_AR |
dc.subtype | cientifico |
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