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In the fall of 2022, decreased triclabendazole (TCBZ) efficacy against F. hepatica was suspected in a sheep farm located in the Santa Cruz province, Argentinian Patagonia. Since TCBZ-resistance in F. hepatica has never been reported in this province, this study aimed to confirm potential TCBZ-resistance in F. hepatica and to evaluate the efficacy of closantel (CLO) and nitroxinil (NTX), through faecal egg count reduction test (FECRT), and the efficacy of
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dc.contributor.author | Larroza, Marcela Patricia | |
dc.contributor.author | Aguilar, Marcelo Javier | |
dc.contributor.author | Soler, Paula | |
dc.contributor.author | Mora, Julio Cesar | |
dc.contributor.author | Roa, Martin Angel | |
dc.contributor.author | Cabrera, Francisco Ra | |
dc.contributor.author | Martinez Stanziola, Juan Pablo | |
dc.contributor.author | Ceballos, Laura | |
dc.contributor.author | Alvarez, Luis | |
dc.coverage.spatial | Santa Cruz .......... (province) (World, South America, Argentina) | es_AR |
dc.coverage.spatial | 1001522 | es_AR |
dc.date.accessioned | 2023-10-25T10:08:03Z | |
dc.date.available | 2023-10-25T10:08:03Z | |
dc.date.issued | 2023-10 | |
dc.identifier.issn | 2405-9390 | |
dc.identifier.other | https://doi.org/10.1016/j.vprsr.2023.100927 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12123/15668 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S2405939023000977 | |
dc.description.abstract | In the fall of 2022, decreased triclabendazole (TCBZ) efficacy against F. hepatica was suspected in a sheep farm located in the Santa Cruz province, Argentinian Patagonia. Since TCBZ-resistance in F. hepatica has never been reported in this province, this study aimed to confirm potential TCBZ-resistance in F. hepatica and to evaluate the efficacy of closantel (CLO) and nitroxinil (NTX), through faecal egg count reduction test (FECRT), and the efficacy of albendazole (ABZ) through the in vitro egg hatch test (EHT) in sheep. Sixty-eight (68) animals were selected from a herd of eighty (80) female Merino naturally infected with F. hepatica based on eggs per gram of F. hepatica (EPGFh) counts and assigned into four (4) groups (n = 17 per group): Group Control, animals did not receive anthelmintic treatment; Group TCBZ, animals were orally treated with TCBZ (12 mg/kg); Group CLO, animals were orally treated with CLO (10 mg/kg); and Group NTX, animals were subcutaneously treated with NTX (10 mg/kg). The fluke egg output was monitored on days 0 and 21 post-treatment. For the EHT, liver fluke eggs were isolated from faecal samples (approx. 50 g) collected from animals of the control group. TCBZ efficacy against liver fluke was 53.4%, confirming the presence of TCBZ-resistant isolates on the farm. CLO and NTX were highly effective (100%) for the treatment of F. hepatica on this farm. The EHT was carried out in two different laboratories, in which was observed an ABZ efficacy of 95.8 (Bariloche) and 96.5% (Tandil). These results indicate the ABZ susceptibility of this F. hepatica isolate and the inter-laboratory precision of the test. | eng |
dc.format | application/pdf | es_AR |
dc.language.iso | eng | es_AR |
dc.publisher | Elsevier | es_AR |
dc.relation | info:eu-repograntAgreement/INTA/2019-PD-E5-I104-001, Estudios sobre generación de resistencia a los antimicrobianos y desarrollo de alternativas profilácticas y terapéuticas | es_AR |
dc.relation | info:eu-repograntAgreement/INTA/2019-PE-E1-I002-001, Tecnologías sostenibles para la estabilización y mejora de la competitividad de las cadenas productivas de ovinos, caprinos y camélidos sudamericanos | es_AR |
dc.rights | info:eu-repo/semantics/restrictedAccess | es_AR |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | es_AR |
dc.source | Veterinary Parasitology: Regional Studies and Reports 45 : 100927. (October 2023) | es_AR |
dc.subject | Ovinos | es_AR |
dc.subject | Sheep | eng |
dc.subject | Fasciola hepatica | eng |
dc.subject | Santa Cruz (Argentina) | es_AR |
dc.subject | Benzimidazoles | eng |
dc.subject | Resistencia a los Antihelmínticos | es_AR |
dc.subject | Resistance to Anthelmintics | eng |
dc.subject | Antihelmínticos | es_AR |
dc.subject | Anthelmintics | eng |
dc.subject.other | Triclabendazole | es_AR |
dc.subject.other | Región Patagónica | es_AR |
dc.title | Triclabendazole resistance in Fasciola hepatica: First report in sheep from the Santa Cruz province, Argentinian Patagonia | es_AR |
dc.type | info:ar-repo/semantics/artículo | es_AR |
dc.type | info:eu-repo/semantics/article | es_AR |
dc.type | info:eu-repo/semantics/publishedVersion | es_AR |
dc.rights.license | Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) | es_AR |
dc.description.origen | EEA Bariloche | es_AR |
dc.description.fil | Fil: Larroza, Marcela Patricia. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Área Producción Animal. Grupo Sanidad Animal; Argentina | es_AR |
dc.description.fil | Fil: Aguilar, Marcelo Javier. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Santa Cruz. Agencia de Extensión Rural San Julián; Argentina. | es_AR |
dc.description.fil | Fil: Soler, Paula. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Área Producción Animal. Grupo Sanidad Animal; Argentina | es_AR |
dc.description.fil | Fil: Mora, Julio Cesar. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Santa Cruz. Agencia de Extensión Rural Los Antiguos; Argentina | es_AR |
dc.description.fil | Fil: Roa, Martin Angel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Santa Cruz. Agencia de Extensión Rural Los Antiguos; Argentina | es_AR |
dc.description.fil | Fil: Cabrera, Francisco Raúl. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Area de Produccion Animal. Grupo de Sanidad Animal; Argentina | es_AR |
dc.description.fil | Fil: Martinez Stanziola, Juan Pablo. Instituto Nacional de Tecnología Agropecuaria (INTA). Centro Regional Patagonia Sur. Estación Experimental Agroforestal Esquel (EEAf Esquel). Campo Anexo Trevelin; Argentina | es_AR |
dc.description.fil | Fil: Ceballos, Laura. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina | es_AR |
dc.description.fil | Fil: Ceballos, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Centro de Investigación Veterinaria de Tandil; Argentina. | es_AR |
dc.description.fil | Fil: Alvarez, Luís. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina | es_AR |
dc.description.fil | Fil: Alvarez, Luís. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Centro de Investigación Veterinaria de Tandil; Argentina. | es_AR |
dc.subtype | cientifico |
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