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Resumen
In the past decade, metagenomics studies exploring tick microbiota have revealed widespread interactions between bacteria and arthropods, including symbiotic interactions. Functional studies showed that obligate endosymbionts contribute to tick biology, affecting reproductive fitness and molting. Understanding the molecular basis of the interaction between ticks and their mutualist endosymbionts may help to develop control methods based on microbiome
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dc.contributor.author | Garcia Guizzo, Melina | |
dc.contributor.author | Tirloni, Lucas | |
dc.contributor.author | Gonzalez, Sergio Alberto | |
dc.contributor.author | Farber, Marisa Diana | |
dc.contributor.author | Braz, Glória | |
dc.contributor.author | Parizi, Luís Fernando | |
dc.contributor.author | Dedavid e Silva, Lucas Andre | |
dc.contributor.author | Da Silva Vaz, Itabajara | |
dc.contributor.author | Oliveira, Pedro L. | |
dc.date.accessioned | 2022-06-24T10:31:46Z | |
dc.date.available | 2022-06-24T10:31:46Z | |
dc.date.issued | 2022-05 | |
dc.identifier.issn | 1664-302X | |
dc.identifier.other | https://doi.org/10.3389/fmicb.2022.868575 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12123/12156 | |
dc.identifier.uri | https://www.frontiersin.org/articles/10.3389/fmicb.2022.868575/full | |
dc.description.abstract | In the past decade, metagenomics studies exploring tick microbiota have revealed widespread interactions between bacteria and arthropods, including symbiotic interactions. Functional studies showed that obligate endosymbionts contribute to tick biology, affecting reproductive fitness and molting. Understanding the molecular basis of the interaction between ticks and their mutualist endosymbionts may help to develop control methods based on microbiome manipulation. Previously, we showed that Rhipicephalus microplus larvae with reduced levels of Coxiella endosymbiont of R. microplus (CERM) were arrested at the metanymph life stage (partially engorged nymph) and did not molt into adults. In this study, we performed a transcriptomic differential analysis of the R. microplus metanymph in the presence and absence of its mutualist endosymbiont. The lack of CERM resulted in an altered expression profile of transcripts from several functional categories. Gene products such as DA-P36, protease inhibitors, metalloproteases, and evasins, which are involved in blood feeding capacity, were underexpressed in CERM-free metanymphs. Disregulation in genes related to extracellular matrix remodeling was also observed in the absence of the symbiont. Taken together, the observed alterations in gene expression may explain the blockage of development at the metanymph stage and reveal a novel physiological aspect of the symbiont-tick-vertebrate host interaction. | eng |
dc.format | application/pdf | es_AR |
dc.language.iso | eng | es_AR |
dc.publisher | Frontiers Media | es_AR |
dc.relation | info:eu-repograntAgreement/INTA/PNBIO-1131043/AR./Bioinformática y Estadística Genómica. | es_AR |
dc.rights | info:eu-repo/semantics/openAccess | es_AR |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | |
dc.source | Frontiers in Microbiology 13 : 868575 (Mayo 2022) | es_AR |
dc.subject | Coxiella | es_AR |
dc.subject | Symbionts | eng |
dc.subject | Simbiontico | es_AR |
dc.subject | Rhipicephalus | eng |
dc.subject | Transcriptome | eng |
dc.subject | Transcriptomas | es_AR |
dc.subject | Microbiomes | eng |
dc.subject | Microbiomas | es_AR |
dc.subject | Animal Health | eng |
dc.subject | Sanidad Animal | es_AR |
dc.subject.other | Rhipicephalus microplus | es_AR |
dc.title | Coxiella endosymbiont of rhipicephalus microplus modulates tick physiology with a major impact in blood feeding capacity | es_AR |
dc.type | info:ar-repo/semantics/artículo | es_AR |
dc.type | info:eu-repo/semantics/article | es_AR |
dc.type | info:eu-repo/semantics/publishedVersion | es_AR |
dc.rights.license | Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) | |
dc.description.origen | Instituto de Biotecnología | es_AR |
dc.description.fil | Fil: Garcia Guizzo, Melina. National Institute of Allergy and Infectious Diseases. Laboratory of Malaria and Vector Research. Vector Biology Section; Estados Unidos | es_AR |
dc.description.fil | Fil: Garcia Guizzo, Melina. Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis; Brasil | es_AR |
dc.description.fil | Fil: Tirloni, Lucas. National Institute of Allergy and Infectious Diseases. Rocky Mountain Laboratories. Laboratory of Bacteriology. Tick-Pathogen Transmission Unit; Estados Unidos | es_AR |
dc.description.fil | Fil: Gonzalez, Sergio Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnologia y Biologia Molecular; Argentina | es_AR |
dc.description.fil | Fil: Gonzalez, Sergio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Farber, Marisa Diana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnologia y Biologia Molecular; Argentina | es_AR |
dc.description.fil | Fil: Farber, Marisa Diana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Braz, Glória. Universidade Federal do Rio de Janeiro. Instituto de Química; Brasil | es_AR |
dc.description.fil | Fil: Parizi, Luís Fernando. Universidade Federal do Rio Grande do Sul. Centro de Biotecnologia; Brasil | es_AR |
dc.description.fil | Fil: Dedavid e Silva, Lucas Andre. Universidade Federal do Rio Grande do Sul. Centro de Biotecnologia; Brasil | es_AR |
dc.description.fil | Fil: Da Silva Vaz, Itabajara. Universidade Federal do Rio Grande do Sul. Centro de Biotecnologia; Brasil | es_AR |
dc.description.fil | Fil: Da Silva Vaz, Itabajara. Universidade Federal do Rio Grande do Sul. Faculdade de Veterinária; Brasil | es_AR |
dc.description.fil | Fil: Da Silva Vaz, Itabajara. Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular; Brasil | es_AR |
dc.description.fil | Fil: Oliveira, Pedro L. Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis; Brasil | es_AR |
dc.description.fil | Fil: Oliveira, Pedro L. Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular; Brasil | es_AR |
dc.subtype | cientifico |
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