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Abstract
Background: Plant miRNAs are a class of small non-coding RNAs that can repress gene expression at the post-transcriptional level by targeting RNA degradation or promoting translational repression. There is increasing evidence that some miRNAs can derive from a group of non-autonomous class II transposable elements called Miniature Inverted-repeat Transposable Elements (MITEs). Results: We used public small RNA and degradome libraries from Triticum [ver mas...]
dc.contributor.authorCrescente, Juan Manuel
dc.contributor.authorZavallo, Diego
dc.contributor.authorDel Vas, Mariana
dc.contributor.authorAsurmendi, Sebastian
dc.contributor.authorHelguera, Marcelo
dc.contributor.authorFernandez, Elmer
dc.contributor.authorVanzetti, Leonardo Sebastian
dc.date.accessioned2022-05-13T10:46:54Z
dc.date.available2022-05-13T10:46:54Z
dc.date.issued2022-02
dc.identifier.issn1471-2164
dc.identifier.otherhttps://doi.org/10.1186/s12864-022-08364-4
dc.identifier.urihttp://hdl.handle.net/20.500.12123/11871
dc.identifier.urihttps://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-022-08364-4
dc.description.abstractBackground: Plant miRNAs are a class of small non-coding RNAs that can repress gene expression at the post-transcriptional level by targeting RNA degradation or promoting translational repression. There is increasing evidence that some miRNAs can derive from a group of non-autonomous class II transposable elements called Miniature Inverted-repeat Transposable Elements (MITEs). Results: We used public small RNA and degradome libraries from Triticum aestivum to screen for microRNAs production and predict their cleavage target sites. In parallel, we also created a comprehensive wheat MITE database by identifying novel elements and compiling known ones. When comparing both data sets, we found high homology between MITEs and 14% of all the miRNAs production sites detected. Furthermore, we show that MITE-derived miRNAs have preference for targeting degradation sites with MITE insertions in the 3’ UTR regions of the transcripts. Conclusions: Our results revealed that MITE-derived miRNAs can underlay the origin of some miRNAs and potentially shape a regulatory gene network. Since MITEs are found in millions of insertions in the wheat genome and are closely linked to genic regions, this kind of regulatory network could have a significant impact on the post-transcriptional control of gene expression.eng
dc.formatapplication/pdfes_AR
dc.language.isoenges_AR
dc.publisherBioMed Centrales_AR
dc.relationinfo:eu-repograntAgreement/INTA/PNBIO-1131022/AR./Genómica funcional y biología de sistemas.es_AR
dc.relationinfo:eu-repograntAgreement/INTA/2019-PD-E6-I116-001/2019-PD-E6-I116-001/AR./Identificación y análisis funcional de genes o redes génicas de interés biotecnológico con fin agropecuario, forestal, agroalimentario y/o agroindustrial.es_AR
dc.rightsinfo:eu-repo/semantics/openAccesses_AR
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.sourceBMC Genomics 23 (1) : 154 (Febrero 2022)es_AR
dc.subjectMicroRNAeng
dc.subjectMicroARNes_AR
dc.subjectTriticum aestivumes_AR
dc.subjectGene Expressioneng
dc.subjectExpresión Génicaes_AR
dc.subjectGene Regulatory Networkseng
dc.subjectRedes de Regulación Génicaes_AR
dc.subjectTrigo
dc.subjectWheateng
dc.subjectTrigo Harinero
dc.subjectSoft Wheateng
dc.subject.otherTrigo Pan
dc.titleGenome-wide identification of MITE-derived microRNAs and their targets in bread wheates_AR
dc.typeinfo:ar-repo/semantics/artículoes_AR
dc.typeinfo:eu-repo/semantics/articlees_AR
dc.typeinfo:eu-repo/semantics/publishedVersiones_AR
dc.rights.licenseCreative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.description.origenInstituto de Biotecnologíaes_AR
dc.description.filFil: Crescente, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes_AR
dc.description.filFil: Zavallo, Diego. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentinaes_AR
dc.description.filFil: Zavallo, Diego. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes_AR
dc.description.filFil: Del Vas, Mariana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentinaes_AR
dc.description.filFil: Del Vas, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes_AR
dc.description.filFil: Asurmendi, Sebastian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentinaes_AR
dc.description.filFil: Asurmendi, Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes_AR
dc.description.filFil: Helguera, Marcelo. Instituto Nacional de Tecnología Agropecuaria (INTA). Centro de Investigaciones Agropecuarias; Argentinaes_AR
dc.description.filFil: Fernandez, Elmer. Universidad Católica de Córdoba. Centro de Investigación y Desarrollo en Inmunología y Enfermedades Infecciosas; Argentinaes_AR
dc.description.filFil: Fernandez, Elmer. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes_AR
dc.description.filFil: Vanzetti, Leonardo Sebastian. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Marcos Juárez; Argentinaes_AR
dc.description.filFil: Vanzetti, Leonardo Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes_AR
dc.subtypecientifico


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