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Abstract
Mycobacterium tuberculosis and Mycobacterium bovis are responsible for tuberculosis in humans and animals, respectively. Both species are closely related and belong to the Mycobacterium tuberculosis complex (MTC). M. tuberculosis is the most ancient species from which M. bovis and other members of the MTC evolved. The genome of M. bovis is over >99.95% identical to that of M. tuberculosis but with seven deletions ranging in size from 1 to 12.7 kb. In [ver mas...]
dc.contributor.authorBigi, María Mercedes
dc.contributor.authorBlanco, Federico Carlos
dc.contributor.authorAraujo, Flabio Ribeiro de
dc.contributor.authorThacker, Tyler C.
dc.contributor.authorZumarraga, Martin Jose
dc.contributor.authorCataldi, Angel Adrian
dc.contributor.authorSoria, Marcelo Abel
dc.contributor.authorBigi, Fabiana
dc.date.accessioned2017-09-11T12:26:47Z
dc.date.available2017-09-11T12:26:47Z
dc.date.issued2016
dc.identifier.issn0385-5600 (Print)
dc.identifier.issn1348-0421 (Online)
dc.identifier.otherDOI: 10.1111/1348-0421.12402
dc.identifier.urihttp://hdl.handle.net/20.500.12123/1186
dc.description.abstractMycobacterium tuberculosis and Mycobacterium bovis are responsible for tuberculosis in humans and animals, respectively. Both species are closely related and belong to the Mycobacterium tuberculosis complex (MTC). M. tuberculosis is the most ancient species from which M. bovis and other members of the MTC evolved. The genome of M. bovis is over >99.95% identical to that of M. tuberculosis but with seven deletions ranging in size from 1 to 12.7 kb. In addition, 1200 single nucleotide mutations in coding regions distinguish M. bovis from M. tuberculosis. In the present study, we assessed 75 M. tuberculosis genomes and 23 M. bovis genomes to identify non-synonymous mutations in 202 coding sequences of regulatory genes between both species. We identified species-specific variants in 20 regulatory proteins and confirmed differential expression of hypoxia-related genes between M. bovis and M. tuberculosiseng
dc.formatapplication/pdf
dc.language.isoeng
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.sourceMicrobiology and Immunology 60 (8) : 552–560. (August 2016)
dc.subjectEnfermedades de los Animales
dc.subjectAnimal Diseaseseng
dc.subjectMycobacterium Tuberculosis
dc.subjectMycobacterium Bovis
dc.subjectEnfermedades Infecciosas
dc.subjectInfectious Diseaseseng
dc.subjectPolimorfismo
dc.subjectPolymorphismeng
dc.titlePolymorphisms of 20 regulatory proteins between Mycobacterium tuberculosis and Mycobacterium bovis
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/acceptedVersion
dc.description.origenInst. de Biotecnología
dc.gic150901
dc.description.filFil: Bigi, María Mercedes. Universidad de Buenos Aires; Argentina
dc.description.filFil: Blanco, Federico Carlos. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina
dc.description.filFil: Araujo, Flabio R. EMBRAPA Mato Grosso do Sul; Brasil
dc.description.filFil: Thacker, Tyler C. United States Department of Agriculture. Agricultural Research Service. National Animal Disease Center; Estados Unidos
dc.description.filFil: Zumarraga, Martin Jose. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina
dc.description.filFil: Cataldi, Angel Adrian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina
dc.description.filFil: Soria, Marcelo Abel. Universidad de Buenos Aires. Facultad de Agronomía. Departamento de Biología Aplicada y Alimentos. Cátedra de Microbiología Agrícola; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Biociencias Agrícolas y Ambientales. Universidad de Buenos Aires. Facultad de Agronomía. Instituto de Investigaciones en Biociencias Agrícolas y Ambientales; Argentina
dc.description.filFil: Bigi, Fabiana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina
dc.subtypecientifico


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