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Abstract
The dewaxed dichloromethane extract of Urolepis hecatantha and the compounds isolated from it were tested for their in vitro activity on Trypanosoma cruzi epimastigotes and Leishmania infantum promastigotes. The extract of U. hecatantha showed activity against both parasites with IC50 values of 7 µg/mL and 31 µg/mL, respectively. Fractionation of the dichloromethane extract led to the isolation of euparin, jaceidin, santhemoidin C, and eucannabinolide. [ver mas...]
dc.contributor.authorElso, Orlando G.
dc.contributor.authorClavin, María
dc.contributor.authorHernandez, Natalia
dc.contributor.authorSlargata, Tomás
dc.contributor.authorBach, Hernán Gerónimo
dc.contributor.authorCatalan, César A.N.
dc.contributor.authorAguilera, Elena
dc.contributor.authorAlvarez, Guzmán
dc.contributor.authorSulsen, Valeria P.
dc.date.accessioned2022-04-29T09:39:06Z
dc.date.available2022-04-29T09:39:06Z
dc.date.issued2021-02-12
dc.identifier.issn1741-427X
dc.identifier.issn1741-4288
dc.identifier.otherhttps://doi.org/10.1155/2021/6622894
dc.identifier.urihttp://hdl.handle.net/20.500.12123/11763
dc.identifier.urihttps://www.hindawi.com/journals/ecam/2021/6622894/
dc.description.abstractThe dewaxed dichloromethane extract of Urolepis hecatantha and the compounds isolated from it were tested for their in vitro activity on Trypanosoma cruzi epimastigotes and Leishmania infantum promastigotes. The extract of U. hecatantha showed activity against both parasites with IC50 values of 7 µg/mL and 31 µg/mL, respectively. Fractionation of the dichloromethane extract led to the isolation of euparin, jaceidin, santhemoidin C, and eucannabinolide. The sesquiterpene lactones eucannabinolide and santhemoidin C were active on T. cruzi with IC50 values of 10 ± 2 µM (4.2 µg/mL) and 18 ± 3 µM (7.6 µg/mL), respectively. Euparin and santhemoidin C were the most active on L. infantum with IC50 values of 18 ± 4 µM (3.9 µg/mL) and 19 ± 4 µM (8.0 µg/mL), respectively. Eucannabinolide has also shown drug-like pharmacokinetic and toxicity properties.eng
dc.formatapplication/pdfes_AR
dc.language.isoenges_AR
dc.publisherHindawies_AR
dc.rightsinfo:eu-repo/semantics/openAccesses_AR
dc.sourceEvidence based complementary and alternative medicine 2021 : Article ID 6622894 (2021)es_AR
dc.subjectUrolepises_AR
dc.subjectActivityeng
dc.subjectActividades_AR
dc.subjectAsteraceae
dc.subjectPropiedades Antimicrobianas
dc.subjectAntimicrobial Propertieseng
dc.subject.otherUrolepis hecatantha
dc.titleAntiprotozoal Compounds from Urolepis hecatantha (Asteraceae)es_AR
dc.typeinfo:ar-repo/semantics/artículoes_AR
dc.typeinfo:eu-repo/semantics/articlees_AR
dc.typeinfo:eu-repo/semantics/publishedVersiones_AR
dc.description.filFil: Elso, Orlando G. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Farmacognosia; Argentina. CONICET–Universidad de Buenos Aires. Instituto de Química y Metabolismo del Fármaco (IQUIMEFA); Argentinaes_AR
dc.description.filFil: Clavin, Maria. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Farmacognosia; Argentina. CONICET–Universidad de Buenos Aires. Instituto de Química y Metabolismo del Fármaco (IQUIMEFA); Argentinaes_AR
dc.description.filFil: Hernández, Natalia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Farmacognosia; Argentina.es_AR
dc.description.filFil: Sgarlata, Tomas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Farmacognosia; Argentina.es_AR
dc.description.filFil: Bach, Hernán Gerónimo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Recursos Biológicos; Argentinaes_AR
dc.description.filFil: Catalán, César A. N. Universidad Nacional de Tucumán. Facultad de Bioquímica Química y Farmacia. Instituto de Química Orgánica; Argentinaes_AR
dc.description.filFil: Aguilera, Elena. Universidad de la República. Facultad de Ciencias. Grupo de Química Medicinal. Laboratorio de Química Orgánica; Uruguayes_AR
dc.description.filFil: Álvarez, Guzmán. Universidad de la República. CENUR Litoral Norte. Laboratorio de Moléculas Bioactivas; Uruguayes_AR
dc.description.filFil: Sulsen, Valeria P. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Farmacognosia; Argentina. CONICET–Universidad de Buenos Aires. Instituto de Química y Metabolismo del Fármaco (IQUIMEFA); Argentinaes_AR
dc.subtypecientifico


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