Show simple item record

resumen

Abstract
Ethnopharmacological relevance: Minthostachys verticillata (Griseb.) Epling (Lamiaceae), known as Peperina is a medicinal native plant, with a traditional use as a digestive, antispasmodic and antidiarrheic. Aim Of The Study: Despite its folkloric use, no scientific evaluation of this plant related to the astrointestinal inflammatory process has been carried out to date. The present study aims to assess the effects of M. verticillata on gastrointestinal [ver mas...]
dc.contributor.authorRodríguez Basso, Angeles
dc.contributor.authorCarranza, A.
dc.contributor.authorZainutti, V.M.
dc.contributor.authorBach, Hernán Gerónimo
dc.contributor.authorGorzalczany, S.B.
dc.date.accessioned2022-04-28T13:41:44Z
dc.date.available2022-04-28T13:41:44Z
dc.date.issued2020-12-25
dc.identifier.issn0378-8741
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S037887412033600X?via%3Dihub
dc.identifier.urihttp://hdl.handle.net/20.500.12123/11761
dc.description.abstractEthnopharmacological relevance: Minthostachys verticillata (Griseb.) Epling (Lamiaceae), known as Peperina is a medicinal native plant, with a traditional use as a digestive, antispasmodic and antidiarrheic. Aim Of The Study: Despite its folkloric use, no scientific evaluation of this plant related to the astrointestinal inflammatory process has been carried out to date. The present study aims to assess the effects of M. verticillata on gastrointestinal system in experimental models. Materials and methods: M. verticillata (250 and 500 mg/kg) was orally tested in a colitis model induced by acetic acid. Colon weight/length ratio, oxidative stress (oxidized and reduced glutathione), histological changes using Alcian blue and hematoxylin & eosin staining and expression of IL1β, TNFα, iNOS, COX-2 were evaluated. The effect of the extract in three additional in vivo models were studied: intestinal motility and diarrhea induced by ricin oil, and visceral pain induced by intracolonic administration of capsaicin. Finally, the activity on con centration response curves of acetylcholine, calcium chloride, potassium and serotonin were achieved in isolated rat jejunum. Results: In the colitis model, M. verticillata induced a significant reduction in the colon weight/length ratio, oxidative stress and expression levels of IL-1β, iNOS and COX-2. Also, the extract diminished the severity of microscopic tissue damage and showed protective effect on goblet cells. Intestinal motility, diarrhea, visceral pain-related behaviors and referred hyperalgesia were significantly reduced when the animals were treated with the extract. Furthermore, in isolated jejunum, M. verticillata significantly reduced the contraction induced by serotonin and acetylcholine. Likewise, the extract non-competitively inhibited the response-concentration induced by CaCl2 and inhibited both low and high K+-induced contractions. Conclusions: This is the first study to validate traditional use of M. verticillata for digestive disorders and demonstrated that its aqueous extract could represent a promising strategy in targeting the multifactorial pathophysiology of inflammatory bowel disease.es_AR
dc.formatapplication/pdfes_AR
dc.language.isoenges_AR
dc.publisherJournal of Ethnopharmacology vol. 269, 2021es_AR
dc.rightsinfo:eu-repo/semantics/openAccesses_AR
dc.sourceJournal of Ethnopharmacology vol. 269, 2021es_AR
dc.subject.otherExperimental colitises_AR
dc.subject.othercolitis experimentales_AR
dc.subject.otherMinthostachys verticillataes_AR
dc.subject.otherAnti-Inflammatoryes_AR
dc.subject.otherantiinflamatorioes_AR
dc.subject.otherIntestinal motilityes_AR
dc.subject.othermotilidad intestinales_AR
dc.subject.otherVisceral paines_AR
dc.subject.otherDolor viscerales_AR
dc.titlePharmacologycal activity of peperina (Minthostachys verticillata) on gastrointestinal tractes_AR
dc.typeinfo:ar-repo/semantics/artículoes_AR
dc.typeinfo:eu-repo/semantics/articlees_AR
dc.typeinfo:ar-repo/semantics/artículoes_AR
dc.typeinfo:eu-repo/semantics/articlees_AR
dc.description.filFil: Rodríguez Basso, A. Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Catedra de Farmacología, Buenos Aires, Argentinaes_AR
dc.description.filFil: Carranza, A. CONICET- Universidad de Buenos Aires. Instituto Alberto C. Taquini de Investigaciones en Medicina Traslacional (IATIMET), Buenos Aires, Argentinaes_AR
dc.description.filFil: Zainutti, V.M. Hospital Interzonal de Agudos “Evita”, Buenos Aires, Argentinaes_AR
dc.description.filFil: Bach, Hernán Gerónimo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Recursos Biológicos; Argentinaes_AR
dc.description.filFil: Gorzalczany, S.B. Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Catedra de Farmacología, Buenos Aires, Argentinaes_AR
dc.subtypecientifico


Files in this item

Thumbnail

This item appears in the following Collection(s)

common

Show simple item record