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Resumen
Plant PIP aquaporins play a central role in controlling plant water status. The current structural model for PIP pH-gating states that the main pH sensor is located in loopD and that all the mobile cytosolic elements participate in a complex interaction network that ensures the closed structure. However, the precise participation of the last part of the C-terminal domain (CT) in PIP pH gating remains unknown. This last part has not been resolved in PIP
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dc.contributor.author | Scochera, Florencia | |
dc.contributor.author | Zerbetto De Palma, Gerardo | |
dc.contributor.author | Canessa Fortuna, Agustina | |
dc.contributor.author | Chevriau, Jonathan | |
dc.contributor.author | Toriano, Roxana | |
dc.contributor.author | Soto, Gabriela Cynthia | |
dc.contributor.author | Zeida, Ari | |
dc.contributor.author | Alleva, Karina Edith | |
dc.date | info:eu-repo/date/embargoEnd/2022-12-15 | |
dc.date.accessioned | 2021-12-15T17:35:27Z | |
dc.date.available | 2021-12-15T17:35:27Z | |
dc.date.issued | 2021-07 | |
dc.identifier.issn | 1742-464X | |
dc.identifier.issn | 1742-4658 | |
dc.identifier.other | https://doi.org/10.1111/febs.16134 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12123/10918 | |
dc.identifier.uri | https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.16134 | |
dc.description.abstract | Plant PIP aquaporins play a central role in controlling plant water status. The current structural model for PIP pH-gating states that the main pH sensor is located in loopD and that all the mobile cytosolic elements participate in a complex interaction network that ensures the closed structure. However, the precise participation of the last part of the C-terminal domain (CT) in PIP pH gating remains unknown. This last part has not been resolved in PIP crystal structures and is a key difference between PIP1 and PIP2 paralogues. Here, by a combined experimental and computational approach, we provide data about the role of CT in pH gating of Beta vulgaris PIP. We demonstrate that the length of CT and the positive charge located among its last residues modulate the pH at which the open/closed transition occurs. We also postulate a molecular-based mechanism for the differential pH sensing in PIP homo- or heterotetramers by performing atomistic molecular dynamics simulations (MDS) on complete models of PIP tetramers. Our findings show that the last part of CT can affect the environment of loopD pH sensors in the closed state. Results presented herein contribute to the understanding of how the characteristics of CT in PIP channels play a crucial role in determining the pH at which water transport through these channels is blocked, highlighting the relevance of the differentially conserved very last residues in PIP1 and PIP2 paralogues. | eng |
dc.format | application/pdf | es_AR |
dc.language.iso | eng | es_AR |
dc.publisher | Wiley | es_AR |
dc.rights | info:eu-repo/semantics/embargoedAccess | es_AR |
dc.source | FEBS Journal (First published: 22 July 2021) | es_AR |
dc.subject | Agua | es_AR |
dc.subject | Water | eng |
dc.subject | Relaciones Planta Agua | es_AR |
dc.subject | Plant Water Relations | eng |
dc.subject | pH | eng |
dc.subject | Membranas Celulares | |
dc.subject | Cell Membranes | eng |
dc.subject.other | Acuaporinas | es_AR |
dc.subject.other | Aquaporin | eng |
dc.title | PIP aquaporin pH sensing is regulated by the length and charge of the C-terminal region | es_AR |
dc.type | info:ar-repo/semantics/artículo | es_AR |
dc.type | info:eu-repo/semantics/article | es_AR |
dc.type | info:eu-repo/semantics/acceptedVersion | es_AR |
dc.description.origen | Instituto de Biotecnología | es_AR |
dc.description.fil | Fil: Scochera, Florencia. Universidad de Buenos Aires, Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Fisicomatemática; Argentina | es_AR |
dc.description.fil | Fil: Zerbetto De Palma, Gerardo. Universidad de Buenos Aires, Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Fisicomatemática; Argentina | es_AR |
dc.description.fil | Fil: Zerbetto De Palma, Gerardo. Universidad de Buenos Aires, Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Fisicoquímica Biológica; Argentina | es_AR |
dc.description.fil | Fil: Zerbetto De Palma, Gerardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Ciudad Universitaria. Instituto de Química y Fisicoquímica Biológica; Argentina | es_AR |
dc.description.fil | Fil: Zerbetto De Palma, Gerardo. Universidad Nacional de Hurlingham. Instituto de Biotecnología; Argentina | es_AR |
dc.description.fil | Fil: Canessa Fortuna, Agustina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Fisicomatemática; Argentina | es_AR |
dc.description.fil | Fil: Chevriau, Jonathan. Consejo Nacional de Investigaciones Científicas y Técnicas; Ciudad Universitaria. Instituto de Química y Fisicoquímica Biológica; Argentina | es_AR |
dc.description.fil | Fil: Chevriau, Jonathan. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Fisicoquímica Biológica; Argentina. | es_AR |
dc.description.fil | Fil: Toriano, Roxana. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica “Bernardo Houssay"; Argentina | es_AR |
dc.description.fil | Fil: Toriano, Roxana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Fisiología y Biofísica “Bernardo Houssay"; Argentina | es_AR |
dc.description.fil | Fil: Soto, Gabriela Cinthia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina | es_AR |
dc.description.fil | Fil: Soto, Gabriela Cinthia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Soto, Gabriela Cinthia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina | es_AR |
dc.description.fil | Fil: Zeida, Ari. Universidad de la República. Facultad de Medicina. Departamento de Bioquímica and Centro de Investigaciones Biomédicas (Ceinbio); Uruguay | es_AR |
dc.description.fil | Fil: Alleva, Karina Edith. Consejo Nacional de Investigaciones Científicas y Técnicas. Ciudad Universitaria. Instituto de Química y Fisicoquímica Biológica; Argentina | es_AR |
dc.description.fil | Fil: Alleva, Karina Edith. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Fisicoquímica Biológica; Argentina. | es_AR |
dc.description.fil | Fil: Alleva, Karina Edith. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Fisicomatemática; Argentina | es_AR |
dc.subtype | cientifico |
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