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Abstract
H65, a fusion protein of three pairs of ESX-secreted antigens of Mycobacterium tuberculosis and Mycobacterium bovis, formulated with the liposomal adjuvant CAF01 has been shown to confer protection against M. tuberculosis infection in mice. In this study, we evaluated the impact of combining BCG with H65 + CAF01 immunization in a M. bovis mouse model of infection. We found that a BCG-H65 + CAF01/ H65 + CAF01 prime-boost scheme induced higher protection [ver mas...]
dc.contributor.authorBlanco, Federico Carlos
dc.contributor.authorGarcia, Elizabeth Andrea
dc.contributor.authorAagaard, Claus
dc.contributor.authorBigi, Fabiana
dc.date.accessioned2021-12-15T16:23:28Z
dc.date.available2021-12-15T16:23:28Z
dc.date.issued2021-05
dc.identifier.issn0034-5288
dc.identifier.otherhttps://doi.org/10.1016/j.rvsc.2021.04.014
dc.identifier.urihttp://hdl.handle.net/20.500.12123/10917
dc.identifier.urihttps://www.sciencedirect.com/science/article/abs/pii/S0034528821001132
dc.description.abstractH65, a fusion protein of three pairs of ESX-secreted antigens of Mycobacterium tuberculosis and Mycobacterium bovis, formulated with the liposomal adjuvant CAF01 has been shown to confer protection against M. tuberculosis infection in mice. In this study, we evaluated the impact of combining BCG with H65 + CAF01 immunization in a M. bovis mouse model of infection. We found that a BCG-H65 + CAF01/ H65 + CAF01 prime-boost scheme induced higher protection than BCG and H65 + CAF01 alone. Altogether, H65 antigen formulated in liposomal adjuvant improved the BCG-induced immune protection, thus making this vaccine strategy a promising tool to control bovine tuberculosis.eng
dc.formatapplication/pdfes_AR
dc.language.isoenges_AR
dc.publisherElsevieres_AR
dc.relationinfo:eu-repograntAgreement/INTA/2019-PD-E5-I102-001/2019-PD-E5-I102-001/AR./Desarrollo de vacunas y tecnologías para mejorar las estrategias profilácticas y terapéuticas de las enfermedades que afectan la producción animal y la salud públicaes_AR
dc.rightsinfo:eu-repo/semantics/embargoedAccesses_AR
dc.sourceResearch in Veterinary Science 136 : 595-597 (May 2021)es_AR
dc.subjectMycobacterium bovises_AR
dc.subjectVacunaes_AR
dc.subjectVaccineseng
dc.subjectControl de Enfermedadeses_AR
dc.subjectDisease Controleng
dc.subjectInfección por Mycobacterium Bovises_AR
dc.subjectMycobacterium Bovis Infectionseng
dc.subject.otherTuberculosis Bovinaes_AR
dc.subject.otherBovine Tuberculosiseng
dc.titleThe subunit vaccine H65 + CAF01 increased the BCG- protection against Mycobacterium bovis infection in a mouse model of bovine tuberculosises_AR
dc.typeinfo:ar-repo/semantics/artículoes_AR
dc.typeinfo:eu-repo/semantics/articlees_AR
dc.typeinfo:eu-repo/semantics/acceptedVersiones_AR
dc.description.origenInstituto de Biotecnologíaes_AR
dc.description.filFil: Blanco, Federico Carlos. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentinaes_AR
dc.description.filFil: Blanco, Federico Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes_AR
dc.description.filFil: Garcia, Elizabeth Andrea. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentinaes_AR
dc.description.filFil: Garcia, Elizabeth Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes_AR
dc.description.filFil: Aagaard, Claus. Statens Serum Institut. Department of Infectious Disease Immunology; Dinamarcaes_AR
dc.description.filFil: Bigi, Fabiana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina.es_AR
dc.description.filFil: Bigi, Fabiana. Consejo Nacional de investigaciones Científicas y Tecnológicas; Argentinaes_AR
dc.subtypecientifico


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