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Resumen
H65, a fusion protein of three pairs of ESX-secreted antigens of Mycobacterium tuberculosis and Mycobacterium bovis, formulated with the liposomal adjuvant CAF01 has been shown to confer protection against M. tuberculosis infection in mice. In this study, we evaluated the impact of combining BCG with H65 + CAF01 immunization in a M. bovis mouse model of infection. We found that a BCG-H65 + CAF01/ H65 + CAF01 prime-boost scheme induced higher protection
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dc.contributor.author | Blanco, Federico Carlos | |
dc.contributor.author | Garcia, Elizabeth Andrea | |
dc.contributor.author | Aagaard, Claus | |
dc.contributor.author | Bigi, Fabiana | |
dc.date.accessioned | 2021-12-15T16:23:28Z | |
dc.date.available | 2021-12-15T16:23:28Z | |
dc.date.issued | 2021-05 | |
dc.identifier.issn | 0034-5288 | |
dc.identifier.other | https://doi.org/10.1016/j.rvsc.2021.04.014 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12123/10917 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/abs/pii/S0034528821001132 | |
dc.description.abstract | H65, a fusion protein of three pairs of ESX-secreted antigens of Mycobacterium tuberculosis and Mycobacterium bovis, formulated with the liposomal adjuvant CAF01 has been shown to confer protection against M. tuberculosis infection in mice. In this study, we evaluated the impact of combining BCG with H65 + CAF01 immunization in a M. bovis mouse model of infection. We found that a BCG-H65 + CAF01/ H65 + CAF01 prime-boost scheme induced higher protection than BCG and H65 + CAF01 alone. Altogether, H65 antigen formulated in liposomal adjuvant improved the BCG-induced immune protection, thus making this vaccine strategy a promising tool to control bovine tuberculosis. | eng |
dc.format | application/pdf | es_AR |
dc.language.iso | eng | es_AR |
dc.publisher | Elsevier | es_AR |
dc.relation | info:eu-repograntAgreement/INTA/2019-PD-E5-I102-001/2019-PD-E5-I102-001/AR./Desarrollo de vacunas y tecnologías para mejorar las estrategias profilácticas y terapéuticas de las enfermedades que afectan la producción animal y la salud pública | es_AR |
dc.rights | info:eu-repo/semantics/embargoedAccess | es_AR |
dc.source | Research in Veterinary Science 136 : 595-597 (May 2021) | es_AR |
dc.subject | Mycobacterium bovis | es_AR |
dc.subject | Vacuna | es_AR |
dc.subject | Vaccines | eng |
dc.subject | Control de Enfermedades | es_AR |
dc.subject | Disease Control | eng |
dc.subject | Infección por Mycobacterium Bovis | es_AR |
dc.subject | Mycobacterium Bovis Infections | eng |
dc.subject.other | Tuberculosis Bovina | es_AR |
dc.subject.other | Bovine Tuberculosis | eng |
dc.title | The subunit vaccine H65 + CAF01 increased the BCG- protection against Mycobacterium bovis infection in a mouse model of bovine tuberculosis | es_AR |
dc.type | info:ar-repo/semantics/artículo | es_AR |
dc.type | info:eu-repo/semantics/article | es_AR |
dc.type | info:eu-repo/semantics/acceptedVersion | es_AR |
dc.description.origen | Instituto de Biotecnología | es_AR |
dc.description.fil | Fil: Blanco, Federico Carlos. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina | es_AR |
dc.description.fil | Fil: Blanco, Federico Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Garcia, Elizabeth Andrea. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina | es_AR |
dc.description.fil | Fil: Garcia, Elizabeth Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Aagaard, Claus. Statens Serum Institut. Department of Infectious Disease Immunology; Dinamarca | es_AR |
dc.description.fil | Fil: Bigi, Fabiana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina. | es_AR |
dc.description.fil | Fil: Bigi, Fabiana. Consejo Nacional de investigaciones Científicas y Tecnológicas; Argentina | es_AR |
dc.subtype | cientifico |
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