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A new gnotobiotic pig model of P[6] human rotavirus infection and disease for preclinical evaluation of rotavirus vaccines
(MDPI, 2022-12)Human rotavirus (HRV) is a leading cause of gastroenteritis in children under 5 years of age. Licensed vaccines containing G1P[8] and G1-4P[8] strains are less efficacious against newly emerging P[6] strains, indicating ... -
Anti-VP6 VHH : an experimental treatment for rotavirus A-associated disease
(2016)Species A Rotaviruses (RVA) remain a leading cause of mortality in children under 5 years of age. Current treatment options are limited. We assessed the efficacy of two VP6-specific llama-derived heavy chain antibody ... -
Assessment of Influential Factors for Scours Associated with Cryptosporidium sp., Rotavirus and Coronavirus in Calves from Argentinean Dairy Farms
(MDPI, 2021-09)Scours is the most common disease in dairy calves, and it is a multifactorial syndrome complex. Cryptosporidium sp. (C. sp.), rotavirus group A (RVA), and bovine coronavirus (BCoV) are the three main pathogens associated ... -
Circulación y caracterización molecular de Rotavirus y Escherichia coli asociados a diarrea neonatal y septicemia en terneros
(Universidad Nacional del Centro de la Provincia de Buenos Aires, Facultad de Ciencias Veterinarias, 2016)Rotavirus, coronavirus y Escherichia coli son causas frecuentes de diarrea y septicemia en terneros neonatos y producen importantes pérdidas económicas. Si bien en Argentina hay estudios de ambos virus, es ... -
Combined live oral priming and intramuscular boosting regimen with Rotarix® and a nanoparticle-based trivalent rotavirus vaccine evaluated in gnotobiotic pig models of G4P[6] and G1P[8] human rotavirus infection
(MDPI, 2023-05)Human rotavirus (HRV) is the causative agent of severe dehydrating diarrhea in children under the age of five, resulting in up to 215,000 deaths each year. These deaths almost exclusively occur in low- and middle-income ... -
Controlling Rotavirus-associated diarrhea: Could single-domain antibody fragments make the difference? = Hacia el control de la diarrea por rotavirus A: ¿podrían los nanoanticuerpos VHH marcar la diferencia?
(Asociación Argentina de Microbiología, 2015-10)Group A Rotavirus (RVA) remains a leading cause of severe diarrhea and child mortality. The variable domain of camelid heavy chain antibodies (VHH) display potent antigen-binding capacity, have low production costs and are ... -
Detection, molecular characterization and phylogenetic analysis of G3P[12] and G14P[12] equine rotavirus strains co-circulating in central Kentucky
(Elsevier, 2018)Equine rotavirus A (ERVA) is the leading cause of diarrhea in neonatal foals and a major health problem to the equine breeding industry worldwide. The G3P[12] and G14P[12] ERVA genotypes are the most prevalent in foals ... -
Development and evaluation of a one-step multiplex real-time TaqMan® RT-qPCR assay for the detection and genotyping of equine G3 and G14 rotaviruses in fecal samples
(BMC, 2019-04)Background: Equine rotavirus A (ERVA) is the leading cause of diarrhea in neonatal foals and has a negative impact on equine breeding enterprises worldwide. Among ERVA strains infecting foals, the genotypes G3P[12] and ... -
Discovery and molecular characterization of a group A rotavirus strain detected in an Argentinean vicuña (Vicugna vicugna)
(Elsevier, 2013-01-25)The wild vicuña (Vicugna vicugna) is one of the four species of native South American camelids (SACs) in addition to the wild guanaco, and their domesticated counterparts, alpaca and llama, respectively. Serological data ... -
Double-layered rotavirus-like particles are efficient carriers to elicit strong CTL responses to delivered heterologous antigens
(Elsevier, 2014-11)The first 92 amino acids of VP2 of rotavirus are dispensable for VLP assembly and can be replaced by heterologous reporter proteins without affecting either self-assembly of chimeric VP2 or the interaction with VP6 to ... -
Equine rotavirus a under the one health lens : potential impacts on public health
(MDPI, 2024-01)Group A rotaviruses are a well-known cause of viral gastroenteritis in infants and children, as well as in many mammalian species and birds, affecting them at a young age. This group of viruses has a double-stranded, ... -
Equine rotavirus in Argentinean foals : an overview
(2016)The aim of the present work is to summarized our knowledge and discuss the future prospects regarding this important disease of foals. -
Evolution of Animal South American RVA Told by the NSP4 Gene E12 Genotype
(MDPI, 2022-11-12)Rotavirus A (RVA) possesses a genome of 11 double-stranded (ds) RNA segments, and each segment encodes one protein, with the exception of segment 11. NSP4 is a non-structural multifunctional protein encoded by segment 10 ... -
First report of group A rotavirus and bovine coronavirus associated with neonatal calf diarrhea in the northwest of Argentina
(Springer, 2020-06)Group A rotavirus (RVA) and bovine coronavirus (BCoV) are the two main viral enteropathogens associated with neonatal calf diarrhea. The aim of the present survey was to investigate the epidemiology and the role of RVA and ... -
GII.4 human norovirus and G8P[1] bovine-like rotavirus in oysters (Crassostrea gigas) from Argentina
(Elsevier, 2022-01-14)Bivalve mollusks have been widely recognized as an important source of foodborne virus. The aim of this work was to determine the presence of norovirus (NoV) and rotavirus (RVA) in Pacific cupped oyster (Crassostrea gigas) ... -
Human rotavirus replicates in salivary glands and primes immune responses in facial and intestinal lymphoid tissues of gnotobiotic pigs
(MDPI, 2023-08)Human rotavirus (HRV) is a leading cause of viral gastroenteritis in children across the globe. The virus has long been established as a pathogen of the gastrointestinal tract, targeting small intestine epithelial cells ... -
Influence of individual or group housing of newborn calves on rotavirus and coronavirus infection during the first 2 months of life
(Springer, 2021-01-03)Bovine rotavirus A (RVA) and bovine coronavirus (CoV) are the two main viral enteropathogens associated with neonatal calf diarrhea. The aim of the present work was to study the impact of group and individual housing systems ... -
Llamas : diagnóstico eficaz del Rotavirus
(Gerencia de Comunicación e Imagen Institucional, DNA SICC, INTA, 2016-12)Investigadores argentinos diseñaron un método innovador para detectar la principal causa de la diarrea neonatal, que afecta a niños menores de cinco años. Basado en nanoanticuerpos VHH, se presenta como una opción rápida ... -
Llamas contra el rotavirus humano
(Gerencia de Comunicación e Imagen Institucional, DNA SICC, INTA, 2012-12)Investigadores argentinos descubrieron una novedosa manera de combatir esta enfermedad diarreica que afecta principalmente a niños menores de cinco años. La presencia de anticuerpos VHH en leche de vaca se presenta como ... -
Molecular characterization of equine rotavirus group A detected in Argentinean foals during 2009–2014
(2017-12)Equine rotavirus group A (RVA) has been detected in several countries worldwide since its first detection in 1975. Currently, equine RVA is considered the major cause of dehydrating diarrhea in foals younger than 3 months, ...