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Mostrando ítems 1-11 de 11
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Cytotoxicity and bioadhesive properties of poly-N-isopropylacrylamide hydrogel
Capella, Virginia; Rivero, Rebeca E.; Liaudat, Ana Cecilia; Ibarra, Luis Exequiel; Roma, Dardo Andrés; Alustiza, Fabrisio Eduardo; Mañas, Fernando; Barbero, César A.; Bosch, Pablo; Rivarola, Claudia R.; Rodríguez, Nancy (Elsevier, 2019-04-09)Several hydrogel surfaces present properties that simulate the mechanical and physicochemical features of extracellular matrix (ECM), providing a platform that mimic the native cellular milieus. Poly-N-isopropylacrylamide ... -
Development and biological evaluation of pNIPAM-based nanogels as vaccine carriers
Soriano Perez, María Laura; Funes, Javier Alejandro; Flores Bracamonte, Carolina; Ibarra, Luis Exequiel; Forrellad, Marina Andrea; Taboga, Oscar Alberto; Cariddi, Laura Noelia; Salinas, Facundo José; Ortega, Hugo Héctor; Alustiza, Fabrisio Eduardo; Molina, Maria (Elsevier, 2023-01)“Smart” nanogels are an attractive tool for the development of new strategies of immunization in veterinary medicine. Here, we reported the synthesis and physicochemical characterization of thermoresponsive nanogels based ... -
Differential innate immune activation by four different CpG-ODNs in porcine and murine cells: Implications for vaccine design
Vedelago, Giuliana; Palacios, Luz M.; Castell, Sofía D.; Marin, Constanza; Ruiz Moreno, Federico N.; Felici, M. Esperanza; Dho, Nicolás D.; Allemandi, Daniel A.; Palma, Santiago D.; Moron, Victor Gabriel; Bessone, Fernando Aníbal; Alustiza, Fabrisio Eduardo; Crespo, Maria Ines; Maletto, Belkys Angélica (Elsevier, 2025-08)Synthetic oligodeoxynucleotides containing unmethylated cytosine-guanine motifs (CpG-ODNs) are immunostimulants widely used as vaccine adjuvants. This study evaluated the innate immune responses induced by four CpG-ODNs: ... -
Evaluation of oral supplementation of free and nanoencapsulated Minthostachys verticillata essential oil on immunological, biochemical and antioxidants parameters and gut microbiota in weaned piglets
Montironi, Ivana D.; Arsaute, Sofía; Roma, Dardo Andrés; Cecchini, María Eugenia; Pinotti, Agustina; Mañas, Fernando; Bessone, Fernando Aníbal; Moreno de LeBlanc, Alejandra de; Alustiza, Fabrisio Eduardo; Bellingeri, Romina; Cariddi, Laura Noelia (Springer, 2024-03)Early weaning is an important stressor that impairs the piglet´s health, and essential oils appear as promising candidates to improve it instead of antibiotics. The aim of this study was to evaluate the effect of oral ... -
Formation of dendrimer-guest complexes as a strategy to increase the solubility of a phenazine N, N′-dioxide derivative with antitumor activity
Dib, Nahir; Fernández, Luciana; Santo, Marisa; Otero, Luis; Alustiza, Fabrisio Eduardo; Liaudat, Ana Cecilia; Bosch, Pablo; Lavaggi, María Laura; Cerecetto, Hugo; González, Mercedes Florencia (Elsevier, 2019-04-23)Poly(amidoamine) and Poly(propylenimine) dendrimers with different generations and peripheral groups were studied as solubility enhancers and nanocarriers for 7-bromo-2-hydroxy-phenazine N5,N10-dioxide. This compound ... -
IgY against enterotoxigenic Escherichia coli administered by hydrogel-carbon nanotubes composites to prevent neonatal diarrhoea in experimentally challenged piglets
Alustiza, Fabrisio Eduardo; Bellingeri, Romina; Picco, Natalia; Motta, Carlos; Grosso, M. Carolina; Barbero, Cesar A.; Acevedo, Diego F.; Vivas, Adriana (2016-06-14)In previous studies, the applicability of polymeric hydrogels for the protection of egg yolk immunoglobulin (IgY) against simulated gastric conditions was established. Thereafter, the performance of the hydrogels was ... -
Langmuir-Blodgett monolayers holding a wound healing active compound and its effect in cell culture. A model for the study of surface mediated drug delivery systems
Fernández, Luciana; Reviglio, Ana Lucía; Heredia, Daniel A.; Morales, Gustavo M.; Santo, Marisa; Otero, Luis; Alustiza, Fabrisio Eduardo; Liaudat, Ana Cecilia; Bosch, Pablo; Larghi, Enrique L.; Bracca, Andrea B.J.; Kaufman, Teodoro S. (Elsevier, 2021-03)Langmuir and Langmuir-Blodgett films holding a synthetic bioinspired wound healing active compound were used as drug-delivery platforms. Palmitic acid Langmuir monolayers were able to incorporate 2-methyltriclisine, a ... -
Nanocomposites based on pH-sensitive hydrogels and chitosan decorated carbon nanotubes with antibacterial properties
Bellingeri, Romina; Mulko, Lucinda; Molina, Maria; Picco, Natalia; Alustiza, Fabrisio Eduardo; Grosso, M. Carolina; Vivas, Adriana; Acevedo, Diego F.; Barbero, Cesar A. (2018-09-01)The present work aimed to study the properties of a novel nanocomposite with promising biomedical applications. Nanocomposites were prepared by the addition of different concentrations of chitosan decorated carbon nanotubes ... -
Nanoemulsion of Minthostachys verticillata essential oil. In-vitro evaluation of its antibacterial activity
Cecchini, María Eugenia; Paoloni, C.; Campra, Noelia; Picco, Natalia; Grosso, M. Carolina; Soriano Perez, María Laura; Alustiza, Fabrisio Eduardo; Cariddi, Laura Noelia; Bellingeri, Romina (Elsevier, 2021)Infectious diseases constitute a problem of great importance for animal and human health, as well as the increasing bacterial resistance to antibiotics. In this context, medicinal plants emerge as an effective alternative ... -
Nanogel-Mediated antigen delivery: Biocompatibility, immunogenicity, and potential for tailored vaccine design across species
Soriano Perez, María Laura; Montironi, Ivana D.; Funes, Javier Alejandro; Margineda, Carlos Augusto; Campra, Noelia; Cariddi, Laura Noelia; Garrido, Juan José; Molina, María; Alustiza, Fabrisio Eduardo (Elsevier, 2024-06-20)Nanotechnology has emerged as a promising avenue for enhancing the efficacy of vaccine delivery systems. This study investigates the utilization of nanogels as carriers for the model antigen ovalbumin, with a focus on in ... -
Presence and characterization of Escherichia coli virulence genes isolated from diseased pigs in the central region of Argentina
Bessone, Fernando Aníbal; Bessone, Gabriela; Marini, Sebastián José; Conde, María Belén; Alustiza, Fabrisio Eduardo; Zielinski, Gustavo Carlos (2017-08)Background: The main pathogen of neonatal and post weaning diarrhea and edema disease (ED) is Escherichia coli and pathotypes involved are enterotoxigenic, enteropathogenic, and shiga toxigenic (ETEC, EPEC, and STEC, ...