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Abstract
Background: Caries is a public health problem, given that it prevails in 60 to 90% of the school-age global population. Multiple factors interact in its etiology, among them dental plaque is necessary to have lactic acid producing microorganisms like Streptococcus from he Mutans group. Existing prevention and treatment measures are not totally effective and generate adverse effects, which is why it is necessary to search for complementary strategies [ver mas...]
dc.contributor.authorTofiño Rivera, Adriana Patricia
dc.contributor.authorOrtega Cuadros, Mailen
dc.contributor.authorGalvis Pareja, David Andrés
dc.contributor.authorJimenez Rios, Hedilka
dc.contributor.authorMerini, Luciano J.
dc.contributor.authorMartínez Pabón, María Cecilia
dc.date.accessioned2018-11-15T17:00:50Z
dc.date.available2018-11-15T17:00:50Z
dc.date.issued2016-12
dc.identifier.issn0378-8741
dc.identifier.otherhttps://doi.org/10.1016/j.jep.2016.10.044
dc.identifier.urihttp://hdl.handle.net/20.500.12123/3908
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0378874116313289?via%3Dihub
dc.description.abstractBackground: Caries is a public health problem, given that it prevails in 60 to 90% of the school-age global population. Multiple factors interact in its etiology, among them dental plaque is necessary to have lactic acid producing microorganisms like Streptococcus from he Mutans group. Existing prevention and treatment measures are not totally effective and generate adverse effects, which is why it is necessary to search for complementary strategies for their management. Aim: The study sought to evaluate the eradication capacity of Streptococcus mutans biofilms and the toxicity on eukaryotic cells of Lippia alba and Cymbopogon citratus essential oils. Methodology: Essential oils were extracted from plant material through steam distillation and then its chemical composition was determined. The MBEC-high-throughput (MBEC-HTP) (Innovotech, Edmonton, Alberta, Canada) assay used to determine the eradication concentration of S. mutans ATCC 35668 strain biofilms. Cytotoxicity was evaluated on CHO cells through the MTT cell proliferation assay. Results: The major components in both oils were Geraniol and Citral; in L. alba 18.9% and 15.9%, respectively, and in C. citratus 31.3% and 26.7%. The L. alba essential oils presented eradication activity against S. mutans biofilms of 95.8% in 0.01 mg/dL concentration and C. citratus essential oils showed said eradication activity of 95.4% at 0.1, 0.01 mg/dL concentrations and of 93.1% in the 0.001 mg/dL concentration; none of the concentrations of both essential oils showed toxicity on CHO cells during 24 h. Conclusion: The L. alba and C. citratus essential oils showed eradication activity against S. mutans biofilms and null cytotoxicity, evidencing the need to conduct further studies that can identify their active components and in order to guide a safe use in treating and preventing dental caries.eng
dc.formatapplication/pdfeng
dc.language.isoeng
dc.publisherElsevieres_AR
dc.rightsinfo:eu-repo/semantics/restrictedAccesseng
dc.sourceJournal of ethnopharmacology 194 : 749-754. (24 December 2016)eng
dc.subjectCymbopogon Citratuses_AR
dc.subjectStreptococcus Mutanses_AR
dc.subjectCytotoxicityeng
dc.subjectCitotoxicidades_AR
dc.subjectDental Carieseng
dc.subjectCaries Dentales_AR
dc.subjectBiological Contaminationeng
dc.subjectContaminación Biológicaes_AR
dc.subjectEssential Oilseng
dc.subjectAceites Esencialeses_AR
dc.subject.otherLippia Albaes_AR
dc.subject.otherBiofilmseng
dc.titleEffect of Lippia alba and Cymbopogon citratus essential oils on biofilms of Streptococcus mutans and cytotoxicity in CHO cellseng
dc.typeinfo:ar-repo/semantics/artículoes_AR
dc.typeinfo:eu-repo/semantics/articleeng
dc.typeinfo:eu-repo/semantics/publishedVersioneng
dc.description.origenEEA Anguiles_AR
dc.description.filFil: Tofiño Rivera, Adriana Patricia. Universidad de Santander. Facultad de Salud. Grupo de Investigación Cienciaudes; Colombiaes_AR
dc.description.filFil: Ortega Cuadros, Mailen. Universidad Popular del Cesar; Colombiaes_AR
dc.description.filFil: Galvis Pareja, David Andrés. Universidad CES; Colombiaes_AR
dc.description.filFil: Jimenez Rios, Hedilka. Universidad de Santander. Facultad de Salud. Grupo de Investigación Cienciaudes; Colombiaes_AR
dc.description.filFil: Merini, Luciano J. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Anguil; Argentinaes_AR
dc.description.filFil: Martínez Pabón, María Cecilia. Universidad de Antioquía. Facultad de Odontología. Laboratorio de Microbiología Bucal. Grupo de Investigación en Patología Oral, Periodoncia y Cirugía Alvéolo-Dentaria; Colombiaes_AR
dc.subtypecientifico


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