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We previously reported that combined fluoxetine administration at antidepressant doses renders additive antidepressant effects, whereas non-antidepressant doses potentiate the omega-3 fatty acid antidepressant effect. In the present study, we aimed to evaluate putative pharmacokinetic and brain omega-3 fatty acid-related aspects for fluoxetine potentiation of omega-3 fatty acid antidepressant effect in rats. Coadministration of omega-3 fatty acids with a
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dc.contributor.author | Laino, Carlos Horacio | |
dc.contributor.author | Garcia, Pilar Teresa | |
dc.contributor.author | Podestá, María Fernanda | |
dc.contributor.author | Höcht, Christian | |
dc.contributor.author | Slobodianik, Nora Haydee | |
dc.contributor.author | Reines, Analia Gabriela | |
dc.date.accessioned | 2018-08-06T15:44:53Z | |
dc.date.available | 2018-08-06T15:44:53Z | |
dc.date.issued | 2014-10 | |
dc.identifier.issn | 0022-3549 | |
dc.identifier.issn | 1520-6017 | |
dc.identifier.other | https://doi.org/10.1002/jps.24123 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0022354915304020 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12123/2985 | |
dc.description.abstract | We previously reported that combined fluoxetine administration at antidepressant doses renders additive antidepressant effects, whereas non-antidepressant doses potentiate the omega-3 fatty acid antidepressant effect. In the present study, we aimed to evaluate putative pharmacokinetic and brain omega-3 fatty acid-related aspects for fluoxetine potentiation of omega-3 fatty acid antidepressant effect in rats. Coadministration of omega-3 fatty acids with a non-antidepressant dose of fluoxetine (1 mg/kg day) failed to affect both brain fluoxetine concentration and norfluoxetine plasma concentration profile. Fluoxetine plasma concentrations remained below the sensitivity limit of the detection method. Either antidepressant (10 mg/kg day) or non-antidepressant (1 mg/kg day) doses of fluoxetine in combination with omega-3 fatty acids increased hippocampal docosapentaenoic acid (DPA, 22:5 omega-3) levels. Although individual treatments had no effects on DPA concentration, DPA increase was higher when omega-3 were combined with the non-antidepressant dose of fluoxetine. Chronic DPA administration exerted antidepressant-like effects in the forced swimming test while increasing hippocampal docosahexaenoic (22:6 omega-3) and DPA levels. Our results suggest no pharmacokinetic interaction and reveal specific hippocampal DPA changes after fluoxetine and omega-3 combined treatments in our experimental conditions. The DPA role in the synergistic effect of fluoxetine and omega-3 combined treatments will be for sure the focus of future studies. | eng |
dc.format | application/pdf | es_AR |
dc.language.iso | eng | es_AR |
dc.rights | info:eu-repo/semantics/restrictedAccess | es_AR |
dc.source | Journal of Pharmaceutical Sciences 103 (10) : 3316-3325 (October 2014) | es_AR |
dc.subject | Acidos Grasos | es_AR |
dc.subject | Fatty Acids | eng |
dc.subject | Farmacocinética | es_AR |
dc.subject | Pharmacokinetics | eng |
dc.subject | Roedores | es_AR |
dc.subject | Rodents | eng |
dc.subject.other | Fluoxetine | es_AR |
dc.subject.other | Omega-3 | es_AR |
dc.subject.other | Efectos Antidepresivos | es_AR |
dc.title | Fluoxetine potentiation of Omega-3 fatty acid antidepressant effect: evaluating pharmacokinetic and brain fatty acid-related aspects in rodents | es_AR |
dc.type | info:ar-repo/semantics/artículo | es_AR |
dc.type | info:eu-repo/semantics/article | es_AR |
dc.type | info:eu-repo/semantics/publishedVersion | es_AR |
dc.description.origen | Instituto de Tecnología de Alimentos | es_AR |
dc.description.fil | Fil: Laino, Carlos Horacio. Universidad Nacional de la Rioja. Centro de Investigación e Innovación Tecnológica. Instituto de Biotecnología; Argentina. | es_AR |
dc.description.fil | Fil: Garcia, Pilar Teresa. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Tecnología de Alimentos; Argentina | es_AR |
dc.description.fil | Fil: Podestá, María Fernanda. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; Argentina | es_AR |
dc.description.fil | Fil: Höcht, Christian. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacología; Argentina. | es_AR |
dc.description.fil | Fil: Slobodianik, Nora Haydee. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Nutrición; Argentina | es_AR |
dc.description.fil | Fil: Reines, Analia Gabriela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; Argentina | es_AR |
dc.subtype | cientifico |
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