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A Neospora caninum vaccine using recombinant proteins fails to prevent foetal infection in pregnant cattle after experimental intravenous challenge
(Elsevier, 2014-12-15)The aim of the present study was to evaluate the immunogenicity and protective efficacy of rNcSAG1, rNcHSP20 and rNcGRA7 recombinant proteins formulated with immune stimulating complexes (ISCOMs) in pregnant heifers against ... -
A safe and effective vaccine against bovine leukemia virus
(Frontiers Media, 2022-08)Previous attempts to develop a vaccine against bovine leukemia virus (BLV) have not been successful because of inadequate or short-lived stimulation of all immunity components. In this study, we designed an approach based ... -
Alternatives for the serological assessment of foot-and-mouth disease vaccine immunity in buffaloes (Bubalus bubalis)
(2018)Buffaloes are compulsory vaccinated against foot-and-mouth disease virus (FMDV) in many countries as part of the official control programmes. Serological testing aimed to indirectly assess herd immunity is currently performed ... -
An indirect ELISA validated as diagnostic and vaccines quality control tool for bovine parainfluenza virus TYPE 3 (BPIV3)
(CNRS (Francia), 2021-07)Serological assays, including enzyme-linked immunosorbent assays (ELISA), provide a useful tool to screen animals for the presence of antibodies (Abs) against a wide range of infectious agents (including viruses that cause ... -
Antibodies to SARS-CoV2 induced by vaccination and infection correlate with protection against the infection
(Elsevier, 2023-10)The COVID-19 pandemic remained worldwide for almost three years, but little is known about the dynamics of humoral immune response to the third dose over time and its protection from infection. Our aim was to assess the ... -
Aseguramiento de la Calidad de los resultados en ensayos de control de la vacuna Candid # 1
(2017-12)Introducción: Candid #1 es una vacuna eficaz para prevenir la fiebre hemorrágica argentina (FHA). Se produce en las instalaciones habilitadas del Instituto Nacional de Enfermedades Virales Humanas "Dr. Julio I. Maiztegui". ... -
Assessment of the potential utility of different regions of Streptococcus uberis adhesion molecule (SUAM) for mastitis subunit vaccine development
(2017-04)Streptococcus uberis is one of the most prevalent pathogens causing clinical and subclinical mastitis worldwide. Among bacterial factors involved in intramammary infections caused by this organism, S. uberis adhesion ... -
BLV: lessons on vaccine development
(BMC, 2019-10-07)Vaccination against retroviruses is a challenge because of their ability to stably integrate into the host genome, undergo long-term latency in a proportion of infected cells and thereby escape immune response. Since ... -
Characterization of a Nanovaccine Platform Based on an α1,2- Mannobiose Derivative Shows Species-non-specific Targeting to Human, Bovine, Mouse, and Teleost Fish Dendritic Cells
(ACS Publications, 2021-07)Dendritic cells serve as the main immune cells that trigger the immune response. We developed a simple and cost-effective nanovaccine platform based on the α1′,2-mannobiose derivative for dendritic cell targeting. In ... -
Comparación de la respuesta inmune humoral y celular de las vacunas Brucella abortus cepa RB51 y cepa 19 en vaquillonas Hereford de Patagonia y su interferencia con el diagnóstico serológico de la enfermedad
(Sociedad de Medicina Veterinaria, 2007)Se llevó a cabo un estudio de campo controlado donde se usaron 2 grupos homogéneos de 25 vaquillonas Hereford cada uno, de 10 meses de edad, provenientes de un establecimiento libre de brucelosis y donde nunca se había ... -
Complete Genome Sequence of Chlamydia abortus MRI-10/19, Isolated from a Sheep Vaccinated with the Commercial Live C. abortus 1B Vaccine Strain
(American Society for Microbiology, 2021-05)We report the complete genome sequence of Chlamydia abortus MRI-10/19, recovered from the infected placenta of a sheep that had been vaccinated with the commercial live attenuated C. abortus 1B vaccine strain. Comparative ... -
Dendritic cell targeting in cultured fish in Argentina for vaccine development
(Edición del Autor, 2019)In Argentina two main species present an important economic value, these are Pacú (Piaractus mesopotamicus, Pm) and Rainbow Trout (Oncorhynchus mykiss, Om). Due to stress and changing environmental conditions cultured fish ... -
Desarrollo de un inmunógeno prototípico para el control de mastitis bovinas causadas por Staphylococcus aureus
(Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, 2012)Staphylococcus aureus es el patógeno más frecuentemente aislado de casos de mastitis bovina en Argentina y el mundo. Las particulares características de las infecciones intramamarias por S. aureus, han llevado a la búsqueda ... -
Development and biological evaluation of pNIPAM-based nanogels as vaccine carriers
(Elsevier, 2023-01)“Smart” nanogels are an attractive tool for the development of new strategies of immunization in veterinary medicine. Here, we reported the synthesis and physicochemical characterization of thermoresponsive nanogels based ... -
Diagnóstico y prevención de la neosporosis bovina. Desarrollo de técnicas serológicas y evaluación de inmunógenos basados en proteínas recombinantes
(Facultad de Ciencias Veterinarias, Universidad Nacional del Litoral, 2019)La neosporosis es una enfermedad abortígena, causada por el parásito protozoario Neospora caninum. No hay tratamientos o vacunas disponibles, el control se basa en el diagnóstico y las estrategias de manejo. Se desarrollaron ... -
Distribution and Severity of Placental Lesions Caused by the Chlamydia abortus 1B Vaccine Strain in Vaccinated Ewes
(MDPI, 2021-05)Chlamydia abortus infects livestock species worldwide and is the cause of enzootic abortion of ewes (EAE). In Europe, control of the disease is achieved using a live vaccine based on C. abortus 1B strain. Although the ... -
Duplex PCR for the diagnosis of Brucella melitensis and its differentiation from the REV-1 vaccine strain
(2016)La brucelosis caprina es una enfermedad infecciosa crónica causada por Brucella melitensis, cuyos principales síntomas son el aborto en mujeres y orquitis en varones. La vacunación por error de cabras embarazadas con la ... -
Effects of the liposomal co-encapsulation of antigen and PO-CpG oligonucleotide on immune response in mice
(International Journal for Research, 2017-06)The development of novel vaccines requires the design of new adjuvants able to give long lasting immune responses. Our aim was to obtain cationic liposomes as adjuvants by an industry-suitable method, and evaluate them ... -
Efficacy of immunization with a recombinant S. aureus vaccine formulated with liposomes and ODN-CpG against natural S. aureus intramammary infections in heifers and cows
(Elsevier, 2022-07)The aims of the present study were to evaluate the ability of a subunit vaccine composed of recombinant molecules of α-toxin, β-toxin, FnBPA and ClfA, formulated with cationic liposomes and CpG-ODN, to confer protection ... -
Estudio de la diversidad genética en poblaciones de Babesia bigemina de diferentes regiones geográficas
(Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, 2013)La babesiosis bovina es una enfermedad enzoótica causada por protozoarios Apicomplexa del género Babesia. En Argentina, esta enfermedad es provocada por B. bovis y B. bigemina, ambas trasmitidas por la garrapata Rhipicephalus ...