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A transcriptional analysis of cattle immune cells reveals a central role of type 1 interferon in the In vitro innate immune response against Mycobacterium bovis
(MDPI, 2023-09)Bovine tuberculosis is a chronic infectious disease primarily caused by Mycobacterium bovis, a bacterium that affects cattle and other mammals, including humans. Despite the availability of vast research about the immune ... -
Assessing the impact of various tuberculin PPD brands on bovine tuberculosis diagnosis
(Springer Nature, 2024-03)Although several brands of tuberculin purified protein derivatives (PPDs) are available for diagnosing bovine tuberculosis (bTB), comparative studies to determine their diagnostic accuracy are infrequent. In Ecuador we ... -
Assessment of tuberculosis biomarkers in paratuberculosis-infected cattle
(Sciendo, 2023-03)Introduction: Mycobacterium bovis and Mycobacterium avium subsp. paratuberculosis, respectively the causative agents of bovine tuberculosis (bTB) and bovine paratuberculosis (PTB), share a high number of antigenic proteins. ... -
BoLA-DRB3 exon2 polymorphisms among tuberculous cattle: Nucleotide and functional variability and their association with bovine tuberculosis pathology
(Elsevier, 2020-06)Bovine tuberculosis (bTB) is caused by Mycobacterium bovis and disseminated worldwide. In Argentina, the highest prevalence occurs in dairy areas. BoLA DRB3.2 is related to the adaptive immunity in mycobacterial infections. ... -
Comparative study of two deleted Mycobacterium bovis strains in experimental animal models
(European Society of Mycobacteriology, 2024-06)Introduction: Bovine tuberculosis (bTB) constitutes a problem for livestock and Public Health due to its negative impact on farms and its zoonotic nature. In Argentina, the application of the National Control and Eradication ... -
Comparison of DRB3.2 alleles among false-negative and positive tuberculin skin test cattle with bovine tuberculosis
(European Society of Mycobacteriology, 2024-06)Introduction: M. bovis is worldwide distributed mainly affecting livestock. Caudal Fold-Tuberculin Skin Test (CF-TST) is the primary screening tool that detects the infection in herds. Some tuberculous animals remain ... -
Deletion in KARLN intron 5 and predictive relationship with bovine tuberculosis and brucellosis infection phenotype
(Springer, 2023-06)Kalirin (gene: KALRN) is a Rho-GEF kinase linked to neurodegenerative diseases in humans. Unexpectedly, various polymorphisms in KALRN gene were previously associated with resistance to bacterial infections in ruminants. ... -
Detección de anticuerpos anti-Mycobacterium bovis en sangre y calostro bovino
(Universidad Nacional del Centro de la Provincia de Buenos Aires, 2023-08)La tuberculosis bovina (TB) es una enfermedad endémica causada principalmente por Mycobacterium bovis. La respuesta inmune es predominantemente celular, siendo la intradermorreacción (IDR) la prueba diagnóstica de referencia. ... -
Diagnóstico bacteriológico de tuberculosis bovina en bovinos reactores positivos a la prueba tuberculínica
(2018-04)Mycobacterium bovis es el agente causal de la tuberculosis bovina (TBB), enfermedad zoonótica que afecta la producción láctea y cárnica. En nuestro país, el diagnóstico se realiza a través de la prueba tuberculínica o ... -
Diversity of the BoLA-DRB3 gene in cattle breeds from tropical and subtropical regions of Argentina
(Springer, 2021-12)Bovine leukocyte antigens (BoLA) have been widely studied because of their primary function in the recognition of pathogens by the immune system. To date, however, the characterization of the BoLA-DRB3 gene in Latin American ... -
Identificación de factores de riesgo de tuberculosis bovina en rodeos lecheros
(Facultad de Ciencias Agrarias, Universidad Nacional de Mar del Plata, 2009-09)La tuberculosis bovina (TBB), producida por el Mycobacterium bovis (M. bovis), es una enfermedad zoonótica endémica en los rodeos bovinos de la Argentina. La información sobre la asociación entre el manejo y la ocurrencia ... -
Live attenuated Mycobacterium bovis strains combined with the encapsulated H65 antigen as a vaccine strategy against bovine tuberculosis in a mouse model
(Elsevier, 2024-04)Mycobacterium bovis is an etiological agent of bovine tuberculosis (bTB) that also infects other mammals, including humans. The lack of an effective vaccine for the control of bTB highlights the need for developing new ... -
Mycobacterium bovis ESAT-6, CFP-10 and EspC antigens show high conservation among field isolates
(Elsevier, 2018-07)ESAT-6, CFP-10 and EspC are virulence factors that have been extensively assayed for bovine and human tuberculosis diagnosis due their potent T-cell inducing activities. While polymorphisms of ESAT-6 and CFP-10 were analyzed, ... -
The subunit vaccine H65 + CAF01 increased the BCG- protection against Mycobacterium bovis infection in a mouse model of bovine tuberculosis
(Elsevier, 2021-05)H65, a fusion protein of three pairs of ESX-secreted antigens of Mycobacterium tuberculosis and Mycobacterium bovis, formulated with the liposomal adjuvant CAF01 has been shown to confer protection against M. tuberculosis ... -
Tuberculosis bovina : transmisibilidad de cepas de Mycobacterium bovis y detección de micobacterias en menudencias comercializadas en bocas de expendio de carne
(Facultad de Ciencias Veterinarias, Universidad de Buenos Aires, 2019)La tuberculosis bovina, causada por Mycobacterium bovis (M. bovis), es endémica en la Argentina. Su presencia en el ganado bovino representa un riesgo para la salud humana debido a su carácter zoonótico, pudiendo además ... -
Tuberculosis in wild pigs from Argentina
(Springer, 2024)Mycobacterium bovis, a member of the Mycobacterium tuberculosis complex (MTC) and non-tuberculous Mycobacteria (NTM), may infect wild and domestic mammals, including humans. Although cattle are the main hosts and spreaders ...