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A new passive immune strategy based on IgY antibodies as a key element to control neonatal calf diarrhea in dairy farms
(BMC, 2020-07)Background: Neonatal diarrhea remains one of the main causes of morbi-mortality in dairy calves under artificial rearing. It is often caused by infectious agents of viral, bacterial, or parasitic origin. Cows vaccination ... -
A novel bacterial protease inhibitor adjuvant in RBD-based COVID-19 vaccine formulations containing alum increases neutralizing antibodies, specific germinal center B cells and confers protection against SARS-CoV-2 infection in mice
(Frontiers Media, 2022-02)In this work, we evaluated recombinant receptor binding domain (RBD)-based vaccine formulation prototypes with potential for further clinical development. We assessed different formulations containing RBD plus alum, AddaS03, ... -
A prime-boost combination of a three-protein cocktail and multiepitopic MVA as a vaccine against Babesia bigemina elicits neutralizing antibodies and a Th1 cellular immune response in mice
(Elsevier, 2022-09)In the intraerythrocytic protozoan parasites of the genus Babesia both innate and adaptive immune responses are necessary to confer protection against clinical disease. In particular, the adaptive immune response involves ... -
A simple and economic three-step process for producing highly purified Fab’ fragments directly from the egg yolk water-soluble fraction
(Elsevier, 2022-11)Although mammals are still the main source of polyclonal antibodies production, the use of egg yolk immunoglobulins (IgY) is increasing, and thus improvement of its safety to reduce undesired reactions is needed. Removal ... -
An applied printing immunoassay with recombinant Nc-SAG1 for detection of antibodies to Neospora caninum in cattle
(Sage Publishing, 2011-08)Neospora caninum is a protozoan parasite that causes an important reproductive disease in cattle. Neospora caninum surface antigen 1 (Nc-SAG1) is an immunodominant candidate for the development of a diagnostic reagent for ... -
Anti-VP6 VHH : an experimental treatment for rotavirus A-associated disease
(2016)Species A Rotaviruses (RVA) remain a leading cause of mortality in children under 5 years of age. Current treatment options are limited. We assessed the efficacy of two VP6-specific llama-derived heavy chain antibody ... -
Babesia bovis AMA-1, MSA-2c and RAP-1 contain conserved B and T-cell epitopes, which generate neutralizing antibodies and a long-lasting Th1 immune response in vaccinated cattle
(Elsevier, 2022-02)Vaccines against bovine babesiosis must, ideally, induce a humoral immune response characterized by neutralizing antibodies against conserved epitopes and a cellular Th1 immune response. In Babesia bovis, proteins such as ... -
Bovine colostral cells : the often forgotten component of colostrum
(American Veterinary Medical Association, 2017-05)Because bovine maternal and fetal blood supplies are kept separate in utero, calves are immunologically naïve immediately after birth, which puts them at high risk for disease. The acquisition of passive immunity, generally ... -
Bovine dendritic cell activation, T cell proliferation and antibody responses to foot-and-mouth disease, is similar with inactivated virus and virus like particles
(Frontiers Media, 2020-09)Foot-and-mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals that causes severe economic losses in the livestock industry. Currently available vaccines are based on the inactivated FMD virus (FMDV). ... -
Brucella spp. Lumazine synthase as a novel immunomodulator to produce egg yolk antibodies
(Scientific Research, 2012-02)Lumazine synthase from Brucella spp. (BLS) is a highly immunogenic decameric protein. It has been previously described as a carrier of peptides or proteins to increase their immunogenicity in different animal species, but ... -
Canarypox virus expressing infectious bursal disease VP2 protein as immunogen for chickens
(Sociedade Brasileira de Microbiologia, 2014-05)Canarypox viruses (CNPV) carrying the coding sequence of VP2 protein from infectious bursal disease virus (IBDV) were obtained. These viruses were able to express VP2 protein in vitro and to induce IBDV-neutralizing ... -
Characterization of colostrum from dams of BLV endemic dairy herds
(Elsevier, 2015-06)Bovine Leukemia Virus (BLV) is endemic in Argentina, where the individual prevalence is higher than 80% in dairy farms. The aim of this work was to find preliminary evidence to know if the high level of infection of the ... -
Characterization of innate immune response to Brucella melitensis infection in goats with permissive or restrictive phenotype for Brucella intramacrophagic growth
(Elsevier, 2021-04)Caprine brucellosis is a chronic, world-wide distributed disease which causes reproductive failure in goats and Brucella melitensis, its causative agent, bears a great zoonotic potential. There is evidence suggesting that ... -
Chicken egg yolk antibodies against bovine respiratory syncytial virus neutralize the virus in vitro
(Elsevier, 2012)Bovine respiratory syncytial virus (BRSV) and its counterpart in humans (HRSV) are two closely related virus, which are the leading cause of severe respiratory syndrome in calves and young children, respectively. Passive ... -
Controlling Rotavirus-associated diarrhea: Could single-domain antibody fragments make the difference? = Hacia el control de la diarrea por rotavirus A: ¿podrían los nanoanticuerpos VHH marcar la diferencia?
(Asociación Argentina de Microbiología, 2015-10)Group A Rotavirus (RVA) remains a leading cause of severe diarrhea and child mortality. The variable domain of camelid heavy chain antibodies (VHH) display potent antigen-binding capacity, have low production costs and are ... -
Desarrollo y evaluación de tecnología para la detección de proteínas no estructurales del Virus de la Fiebre Aftosa en formulaciones vacunales
(Universidad Nacional de San Martín, 2009)La fiebre aftosa (FA) es una enfermedad viral altamente contagiosa que afecta a todas las especies de pezuña hendida, salvajes y domésticas. Las especies domésticas principalmente afectadas son los bovinos, porcinos, ovinos ... -
Detección de anticuerpos anti-Mycobacterium bovis en sangre y calostro bovino
(Universidad Nacional del Centro de la Provincia de Buenos Aires, 2023-08)La tuberculosis bovina (TB) es una enfermedad endémica causada principalmente por Mycobacterium bovis. La respuesta inmune es predominantemente celular, siendo la intradermorreacción (IDR) la prueba diagnóstica de referencia. ... -
Development and evaluation of a new lateral flow assay for simultaneous detection of antibodies against African horse sickness and equine infectious anemia viruses
(2016)African horse sickness (AHS) and equine infectious anemia (EIA) are both notifiable equid specific diseases that may present similar clinical signs. Considering the increased global movement of horses and equine products ... -
Development and validation of a novel ELISA for the detection of Neospora caninum antibodies in bovine sera
(Annex Publishers, 2019-08-26)Neospora caninum is a world-wide distributed apicomplexan parasite, causative agent of bovine neosporosis, which is one of the major causes of reproductive losses in cattle affecting both dairy and beef industries. Several ... -
Development of a lateral flow immunochromatography test for the rapid detection of bovine tuberculosis
(Elsevier, 2021-04)Detection of specific antibodies would be a useful test strategy for bovine tuberculosis (bTB) as a complement to the single skin test. We developed a lateral flow immunochromatography (LFIC) test for rapid bTB detection ...