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Here we confirm the efficacy of MbΔmce2-phoP to protect mice against bTB challenge and we demonstrated that this new attenuated strain is safer than our previous bTB vaccine MbΔmce2. Altogether these results support the further assessment of this candidate in cattle model of bTB.Experiments with mice were performed in compliance with the regulations of the Institutional Animal Care and Use [ver mas...]
dc.contributor.authorGarcia, Elizabeth Andrea
dc.contributor.authorBianco, Marí­a Veronica
dc.contributor.authorBlanco, Federico Carlos
dc.contributor.authorBigi, Fabiana
dc.date.accessioned2017-08-28T13:59:35Z
dc.date.available2017-08-28T13:59:35Z
dc.date.issued2016
dc.identifier.citationGarcía E, Bianco M, Blanco F, Bigi F (2016) Mycobacterium bovis deleted in mce2 and phoP loci protects C57BL/6 mice against tuberculosis. The Journal Of Infection In Developing Countries 10 (08): 892-894. https://doi.org/10.3855/jidc.7721
dc.identifier.issn2036-6590 (Print)
dc.identifier.issn1972-2680 (Online)
dc.identifier.otherhttps://doi.org/10.3855/jidc.7721
dc.identifier.urihttp://hdl.handle.net/20.500.12123/1053
dc.identifier.urihttps://jidc.org/index.php/journal/article/view/27580338/1568
dc.description.abstractHere we confirm the efficacy of MbΔmce2-phoP to protect mice against bTB challenge and we demonstrated that this new attenuated strain is safer than our previous bTB vaccine MbΔmce2. Altogether these results support the further assessment of this candidate in cattle model of bTB.Experiments with mice were performed in compliance with the regulations of the Institutional Animal Care and Use Committee (CICUAE) of INTA (61/2014)..eng
dc.formatapplication/pdf
dc.language.isoeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.sourceJournal Of Infection In Developing Countries 10 (8): 892-894 (August 2016)
dc.subjectEnfermedades de los Animales
dc.subjectAnimal Diseaseseng
dc.subjectMycobacterium Bovis
dc.subjectTuberculosis
dc.subjectInfección por Mycobacterium Bovis
dc.subjectMycobacterium Bovis Infectionseng
dc.titleMycobacterium bovis deleted in mce2 and phoP loci protects C57BL/6 mice against tuberculosis
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.rights.licenseCreative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.description.origenInst. de Biotecnología
dc.gic152231
dc.description.filFil: Garcia, Elizabeth Andrea. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina
dc.description.filFil: Bianco, Marí­a Veronica. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Fisiología y Recursos Genéticos Vegetales; Argentina
dc.description.filFil: Blanco, Federico Carlos. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina
dc.description.filFil: Bigi, Fabiana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina
dc.subtypecientifico


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