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Mycobacterium bovis deleted in mce2 and phoP loci protects C57BL/6 mice against tuberculosis

Abstract
Here we confirm the efficacy of MbΔmce2-phoP to protect mice against bTB challenge and we demonstrated that this new attenuated strain is safer than our previous bTB vaccine MbΔmce2. Altogether these results support the further assessment of this candidate in cattle model of bTB.Experiments with mice were performed in compliance with the regulations of the Institutional Animal Care and Use [ver mas...]
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Author
Garcia, Elizabeth Andrea;   Bianco, Marí­a Veronica;   Blanco, Federico Carlos;   Bigi, Fabiana;  
Fuente
Journal Of Infection In Developing Countries 10 (8): 892-894 (August 2016)
Date
2016
ISSN
2036-6590 (Print)
1972-2680 (Online)
URI
http://hdl.handle.net/20.500.12123/1053
https://jidc.org/index.php/journal/article/view/27580338/1568
DOI
https://doi.org/10.3855/jidc.7721
Formato
pdf
Tipo de documento
article
Palabras Claves
Enfermedades de los Animales; Animal Diseases; Mycobacterium Bovis; Tuberculosis; Infección por Mycobacterium Bovis; Mycobacterium Bovis Infections;
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