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Ten years ago the first plant-based vaccine was licensed (DowAgrosciences). It was only 20 years after the first report of a recombinant protein obtained through plant transformation technology. Back then, this vaccine was perceived as the first of an unlimited list of innovative products of a flourishing platform. Unexpectedly, since then, no other veterinary product based on plant molecular pharming (PMP) has reached the market. This review will [ver mas...]
dc.contributor.authorPerez Aguirreburualde, Maria Sol
dc.contributor.authorPetruccelli, Silvana
dc.contributor.authorBravo Almonacid, Fernando Felix
dc.contributor.authorWigdorovitz, Andres
dc.date.accessioned2017-08-15T11:41:08Z
dc.date.available2017-08-15T11:41:08Z
dc.date.issued2016-12
dc.identifier.issn2198-6428
dc.identifier.otherhttps://doi.org/10.1007/s40610-016-0047-1
dc.identifier.urihttp://hdl.handle.net/20.500.12123/966
dc.identifier.urihttps://link.springer.com/content/pdf/10.1007%2Fs40610-016-0047-1.pdf
dc.description.abstractTen years ago the first plant-based vaccine was licensed (DowAgrosciences). It was only 20 years after the first report of a recombinant protein obtained through plant transformation technology. Back then, this vaccine was perceived as the first of an unlimited list of innovative products of a flourishing platform. Unexpectedly, since then, no other veterinary product based on plant molecular pharming (PMP) has reached the market. This review will reflect a transdisciplinary view of the status and challenges that the molecular farming platform faces to become a strategic solution for the agroindustrial sector of developing countries. Recent findings Plant-based veterinary vaccines (PBVV) have the potential to give answers to several challenges that animal health presents today. The urgent need to improve livestock productivity, especially in low and middle-income countries (LMIC), and the current concern about the emergence of antimicrobial resistance associated with animal production, demands new products such as inexpensive vaccines and therapeutics. Based on the translational research scheme, certain barriers that could have limited the development into products of many results obtained in the last 15 years were identified. Summary Unquestionably, the development of innovation in LMIC is a key element in the feasibility of the platform. The emergence of PPP between multiple stakeholders as a strategy to overcome the existing disconnection between academia and industry, could enable the conversion of leading vaccine candidates from the stage of proof of concept into prototypes for industry, and thereby foster ‘productization’ in the field of veterinary vaccines.
dc.formatapplication/pdf
dc.language.isoeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourceCurrent molecular biology reports 2 (4) : 171–179. (dec. 2016)
dc.subjectGenética
dc.subjectGanado
dc.subjectLivestockeng
dc.subjectGeneticseng
dc.subjectVacuna
dc.subjectVaccineseng
dc.subjectDeveloping Countrieseng
dc.subjectPaíses en desarrollo
dc.titlePlant-based vaccine for livestock : key points to unleash platform translation in developing countries
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.description.origenInst. de Patobiología
dc.gic152228
dc.description.filFil: Perez Aguirreburualde, Maria Sol. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina
dc.description.filFil: Petruccelli, Silvana. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos; Argentina
dc.description.filFil: Bravo Almonacid, Fernando Felix. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular; Argentina
dc.description.filFil: Wigdorovitz, Andrés. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.subtypecientifico


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