Mostrar el registro sencillo del ítem
resumen
Resumen
Chlamydia abortus infects livestock species worldwide and is the cause of enzootic abortion of ewes (EAE). In Europe, control of the disease is achieved using a live vaccine based on C. abortus 1B strain. Although the vaccine has been useful for controlling disease outbreaks, abortion events due to the vaccine have been reported. Recently, placental pathology resulting from a vaccine type strain (vt) infection has been reported and shown to be similar to
[ver mas...]
dc.contributor.author | Caspe, Sergio Gaston | |
dc.contributor.author | Palarea-Albaladejo, Javier | |
dc.contributor.author | Underwood, Clare | |
dc.contributor.author | Livingstone, Morag | |
dc.contributor.author | Wattegedera, Sean Ranjan | |
dc.contributor.author | Milne, Elspeth | |
dc.contributor.author | Sargison, Neil Donald | |
dc.contributor.author | Chianini, Francesca | |
dc.contributor.author | Longbottom, David | |
dc.date.accessioned | 2021-06-11T11:59:10Z | |
dc.date.available | 2021-06-11T11:59:10Z | |
dc.date.issued | 2021-05 | |
dc.identifier.issn | 2076-0817 | |
dc.identifier.other | https://doi.org/10.3390/pathogens10050543 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12123/9561 | |
dc.identifier.uri | https://www.mdpi.com/2076-0817/10/5/543 | |
dc.description.abstract | Chlamydia abortus infects livestock species worldwide and is the cause of enzootic abortion of ewes (EAE). In Europe, control of the disease is achieved using a live vaccine based on C. abortus 1B strain. Although the vaccine has been useful for controlling disease outbreaks, abortion events due to the vaccine have been reported. Recently, placental pathology resulting from a vaccine type strain (vt) infection has been reported and shown to be similar to that resulting from a natural wild-type (wt) infection. The aim of this study was to extend these observations by comparing the distribution and severity of the lesions, the composition of the predominating cell infiltrate, the amount of bacteria present and the role of the blood supply in infection. A novel system for grading the histological and pathological features present was developed and the resulting multi-parameter data were statistically transformed for exploration and visualisation through a tailored principal component analysis (PCA) to evaluate the difference between them. The analysis provided no evidence of meaningful differences between vt and wt strains in terms of the measured pathological parameters. The study also contributes a novel methodology for analysing the progression of infection in the placenta for other abortifacient pathogens. | eng |
dc.format | application/pdf | es_AR |
dc.language.iso | eng | es_AR |
dc.publisher | MDPI | es_AR |
dc.rights | info:eu-repo/semantics/openAccess | es_AR |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | |
dc.source | Pathogens 10 (5) : 543 (April 2021) | es_AR |
dc.subject | Oveja | es_AR |
dc.subject | Ewes | eng |
dc.subject | Enfermedades de los Animales | es_AR |
dc.subject | Animal Diseases | eng |
dc.subject | Chlamydophila abortus | es_AR |
dc.subject | Vacuna | es_AR |
dc.subject | Vaccines | eng |
dc.subject | Placenta | es_AR |
dc.subject | Chlamydia | es_AR |
dc.subject | Control de Enfermedades | es_AR |
dc.subject | Diseases Control | eng |
dc.subject.other | Chlamydia abortus | es_AR |
dc.title | Distribution and Severity of Placental Lesions Caused by the Chlamydia abortus 1B Vaccine Strain in Vaccinated Ewes | es_AR |
dc.type | info:ar-repo/semantics/artículo | es_AR |
dc.type | info:eu-repo/semantics/article | es_AR |
dc.type | info:eu-repo/semantics/publishedVersion | es_AR |
dc.rights.license | Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) | |
dc.description.origen | EEA Mercedes | es_AR |
dc.description.fil | Fil: Caspe, Sergio Gaston. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Mercedes; Argentina | es_AR |
dc.description.fil | Fil: Caspe, Sergio Gaston. Moredun Research Institute; Reino Unido | es_AR |
dc.description.fil | Fil: Caspe, Sergio Gaston. University of Edinburgh. Royal (Dick) School of Veterinary Studies; Reino Unido | es_AR |
dc.description.fil | Fil: Palarea-Albaladejo, Javier. Biomathematics & Statistics Scotland; Reino Unido | es_AR |
dc.description.fil | Fil: Underwood, Clare. Moredun Research Institute; Reino Unido | es_AR |
dc.description.fil | Fil: Livingstone, Morag. Moredun Research Institute; Reino Unido | es_AR |
dc.description.fil | Fil: Wattegedera, Sean Ranjan. Moredun Research Institute; Reino Unido | es_AR |
dc.description.fil | Fil: Milne, Elspeth. University of Edinburgh. Royal (Dick) School of Veterinary Studies; Reino Unido | es_AR |
dc.description.fil | Fil: Sargison, Neil Donald. University of Edinburgh. Royal (Dick) School of Veterinary Studies; Reino Unido | es_AR |
dc.description.fil | Fil: Chianini, Francesca. Moredun Research Institute; Reino Unido | es_AR |
dc.description.fil | Fil: Longbottom, David. Moredun Research Institute; Reino Unido | es_AR |
dc.subtype | cientifico |
Ficheros en el ítem
Este ítem aparece en la(s) siguiente(s) colección(ones)
common