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Abstract
Chlamydia abortus infects livestock species worldwide and is the cause of enzootic abortion of ewes (EAE). In Europe, control of the disease is achieved using a live vaccine based on C. abortus 1B strain. Although the vaccine has been useful for controlling disease outbreaks, abortion events due to the vaccine have been reported. Recently, placental pathology resulting from a vaccine type strain (vt) infection has been reported and shown to be similar to [ver mas...]
dc.contributor.authorCaspe, Sergio Gaston
dc.contributor.authorPalarea-Albaladejo, Javier
dc.contributor.authorUnderwood, Clare
dc.contributor.authorLivingstone, Morag
dc.contributor.authorWattegedera, Sean Ranjan
dc.contributor.authorMilne, Elspeth
dc.contributor.authorSargison, Neil Donald
dc.contributor.authorChianini, Francesca
dc.contributor.authorLongbottom, David
dc.date.accessioned2021-06-11T11:59:10Z
dc.date.available2021-06-11T11:59:10Z
dc.date.issued2021-05
dc.identifier.issn2076-0817
dc.identifier.otherhttps://doi.org/10.3390/pathogens10050543
dc.identifier.urihttp://hdl.handle.net/20.500.12123/9561
dc.identifier.urihttps://www.mdpi.com/2076-0817/10/5/543
dc.description.abstractChlamydia abortus infects livestock species worldwide and is the cause of enzootic abortion of ewes (EAE). In Europe, control of the disease is achieved using a live vaccine based on C. abortus 1B strain. Although the vaccine has been useful for controlling disease outbreaks, abortion events due to the vaccine have been reported. Recently, placental pathology resulting from a vaccine type strain (vt) infection has been reported and shown to be similar to that resulting from a natural wild-type (wt) infection. The aim of this study was to extend these observations by comparing the distribution and severity of the lesions, the composition of the predominating cell infiltrate, the amount of bacteria present and the role of the blood supply in infection. A novel system for grading the histological and pathological features present was developed and the resulting multi-parameter data were statistically transformed for exploration and visualisation through a tailored principal component analysis (PCA) to evaluate the difference between them. The analysis provided no evidence of meaningful differences between vt and wt strains in terms of the measured pathological parameters. The study also contributes a novel methodology for analysing the progression of infection in the placenta for other abortifacient pathogens.eng
dc.formatapplication/pdfes_AR
dc.language.isoenges_AR
dc.publisherMDPIes_AR
dc.rightsinfo:eu-repo/semantics/openAccesses_AR
dc.sourcePathogens 10 (5) : 543 (April 2021)es_AR
dc.subjectOvejaes_AR
dc.subjectEweseng
dc.subjectEnfermedades de los Animaleses_AR
dc.subjectAnimal Diseaseseng
dc.subjectChlamydophila abortuses_AR
dc.subjectVacunaes_AR
dc.subjectVaccineseng
dc.subjectPlacentaes_AR
dc.subjectChlamydiaes_AR
dc.subjectControl de Enfermedadeses_AR
dc.subjectDiseases Controleng
dc.subject.otherChlamydia abortuses_AR
dc.titleDistribution and Severity of Placental Lesions Caused by the Chlamydia abortus 1B Vaccine Strain in Vaccinated Eweses_AR
dc.typeinfo:ar-repo/semantics/artículoes_AR
dc.typeinfo:eu-repo/semantics/articlees_AR
dc.typeinfo:eu-repo/semantics/publishedVersiones_AR
dc.description.origenEEA Mercedeses_AR
dc.description.filFil: Caspe, Sergio Gaston. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Mercedes; Argentinaes_AR
dc.description.filFil: Caspe, Sergio Gaston. Moredun Research Institute; Reino Unidoes_AR
dc.description.filFil: Caspe, Sergio Gaston. University of Edinburgh. Royal (Dick) School of Veterinary Studies; Reino Unidoes_AR
dc.description.filFil: Palarea-Albaladejo, Javier. Biomathematics & Statistics Scotland; Reino Unidoes_AR
dc.description.filFil: Underwood, Clare. Moredun Research Institute; Reino Unidoes_AR
dc.description.filFil: Livingstone, Morag. Moredun Research Institute; Reino Unidoes_AR
dc.description.filFil: Wattegedera, Sean Ranjan. Moredun Research Institute; Reino Unidoes_AR
dc.description.filFil: Milne, Elspeth. University of Edinburgh. Royal (Dick) School of Veterinary Studies; Reino Unidoes_AR
dc.description.filFil: Sargison, Neil Donald. University of Edinburgh. Royal (Dick) School of Veterinary Studies; Reino Unidoes_AR
dc.description.filFil: Chianini, Francesca. Moredun Research Institute; Reino Unidoes_AR
dc.description.filFil: Longbottom, David. Moredun Research Institute; Reino Unidoes_AR
dc.subtypecientifico


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