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resumen

Resumen
The purpose of this study was to identify genomic regions explaining a major proportion of the genetic variance in milk production and milk fat and protein content on a commercial herd of Holstein and Holstein x Jersey crossbred cattle bred in an extensive grazing system. We analyzed 305-day cumulative milk production records from 18876 cows at first lactation, of which 16907 and 16735 had milk fat and protein content records during the same period. After [ver mas...]
dc.contributor.authorRaschia, Maria Agustina
dc.contributor.authorNani, Juan Pablo
dc.contributor.authorCarignano, Hugo Adrian
dc.contributor.authorAmadio, Ariel
dc.contributor.authorMaizon, Daniel Omar
dc.contributor.authorPoli, Mario Andres
dc.date.accessioned2020-10-22T16:32:30Z
dc.date.available2020-10-22T16:32:30Z
dc.date.issued2020-12
dc.identifier.issn1871-1413
dc.identifier.otherhttps://doi.org/10.1016/j.livsci.2020.104294
dc.identifier.urihttp://hdl.handle.net/20.500.12123/8109
dc.identifier.urihttps://www.sciencedirect.com/science/article/abs/pii/S187114132030281X
dc.description.abstractThe purpose of this study was to identify genomic regions explaining a major proportion of the genetic variance in milk production and milk fat and protein content on a commercial herd of Holstein and Holstein x Jersey crossbred cattle bred in an extensive grazing system. We analyzed 305-day cumulative milk production records from 18876 cows at first lactation, of which 16907 and 16735 had milk fat and protein content records during the same period. After data quality control, genotypes from 998 animals on 40417 SNPs included in the Illumina Bovine SNP50 v2 BeadChip were available. Weighted single-step genome-wide association studies were conducted for milk yield (MY), fat content (FC) and protein content (PC). Windows of 10 adjacent single nucleotide polymorphisms explaining more than 0.31% of the genetic variance were considered relevant. Protein-coding genes located within those windows were retrieved, their functional relevance was assessed, the main functional categories and biological processes represented by them were identified, and an overrepresentation test was performed. Relevant windows for MY, FC and PC were 52, 57 and 56, and harbored 304, 293 and 269 proteincoding genes, respectively. The proteins encoded by those genes were mainly involved in cellular, metabolic and biological regulation processes. Cellular response to cytokine stimulus, GTPase activity and GTP binding, and heterotrimeric G-protein were the main overrepresented biological process, molecular functions, and protein class, respectively. Among the candidate genes found, some previously reported genes associated with milk traits, such as CDH2, DGAT1, GRINA, LIPA, PGR, RPGRIP1L, VPS28, MAF1, and FTO were identified. However, novel candidate genes related to transcriptional regulation and transporter activity were also found. These results contribute to a better understanding of the loci influencing milk traits in the main dairy cattle breeds in Argentina.eng
dc.formatapplication/pdfes_AR
dc.language.isoenges_AR
dc.publisherElsevieres_AR
dc.relationinfo:eu-repograntAgreement/INTA/PNBIO-1131033/AR./Genómica y biotecnología aplicada a la cría animal.es_AR
dc.relationinfo:eu-repograntAgreement/INTA/PNBIO-1131043/AR./Bioinformática y Estadística Genómica.es_AR
dc.relationinfo:eu-repograntAgreement/INTA/2019-PE-E6-I145-001/2019-PE-E6-I145-001/AR./Mejora genética objetiva para aumentar la eficiencia de los sistemas de producción animal.es_AR
dc.rightsinfo:eu-repo/semantics/restrictedAccesses_AR
dc.sourceLivestock Science 242 : 104294 (Diciembre 2020)es_AR
dc.subjectCrossbredseng
dc.subjectProductos del Cruzamientoes_AR
dc.subjectDairy Cattleeng
dc.subjectGanado de Lechees_AR
dc.subjectMilk Fateng
dc.subjectGrasa de la Lechees_AR
dc.subjectMilk Proteineng
dc.subjectProteínas de la Lechees_AR
dc.subjectMilk Yieldeng
dc.subjectRendimiento Lecheroes_AR
dc.subjectGenomeseng
dc.subjectGenomases_AR
dc.subjectGenetic Varianceeng
dc.subjectVarianza Genéticaes_AR
dc.subject.otherRaza Holsteines_AR
dc.subject.otherRaza Holstein x Jerseyes_AR
dc.titleWeighted single-step genome-wide association analyses for milk traits in Holstein and Holstein x Jersey crossbred dairy cattlees_AR
dc.typeinfo:ar-repo/semantics/artículoes_AR
dc.typeinfo:eu-repo/semantics/articlees_AR
dc.typeinfo:eu-repo/semantics/publishedVersiones_AR
dc.description.origenInstituto de Genéticaes_AR
dc.description.filFil: Raschia, Maria Agustina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentinaes_AR
dc.description.filFil: Nani, Juan Pablo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentinaes_AR
dc.description.filFil: Carignano, Hugo Adrian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentinaes_AR
dc.description.filFil: Amadio, Ariel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes_AR
dc.description.filFil: Maizon, Daniel Omar. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Anguil; Argentinaes_AR
dc.description.filFil: Poli, Mario Andres. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentinaes_AR
dc.subtypecientifico


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