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Abstract
Babesia ovis is a tick‐transmitted protozoan haemoparasite causing ovine babesiosis in sheep and goats leading to considerable economic loss in Turkey and neighbouring countries. There are no vaccines available, therapeutic drugs leave toxic residues in meat and milk, and tick vector control entails environmental risks. A panel of eight mini‐ and micro‐satellite marker loci was developed and applied to study genetic diversity and substructuring of B. ovis [ver mas...]
dc.contributor.authorMira, Anabela
dc.contributor.authorUnlu, Ahmet Hakan
dc.contributor.authorBilgic, Huseyin Bilgin
dc.contributor.authorBakirci, Serkan
dc.contributor.authorHacilarlioglu, Selin
dc.contributor.authorKaragenc, Tulin
dc.contributor.authorCarletti, Tamara
dc.contributor.authorWeir, William
dc.contributor.authorShiels, Brian
dc.contributor.authorShkap, Varda
dc.contributor.authorAktas, Munir
dc.contributor.authorFlorin‐Christensen, Mónica
dc.contributor.authorSchnittger, Leonhard
dc.date.accessioned2020-08-27T16:41:26Z
dc.date.available2020-08-27T16:41:26Z
dc.date.issued2020-07
dc.identifier.issn1865-1674
dc.identifier.otherhttps://doi.org/10.1111/tbed.13174
dc.identifier.urihttp://hdl.handle.net/20.500.12123/7778
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/full/10.1111/tbed.13174
dc.description.abstractBabesia ovis is a tick‐transmitted protozoan haemoparasite causing ovine babesiosis in sheep and goats leading to considerable economic loss in Turkey and neighbouring countries. There are no vaccines available, therapeutic drugs leave toxic residues in meat and milk, and tick vector control entails environmental risks. A panel of eight mini‐ and micro‐satellite marker loci was developed and applied to study genetic diversity and substructuring of B. ovis from western, central and eastern Turkey. A high genetic diversity (He = 0.799) was found for the sample of overall B. ovis population (n = 107) analyzed. Principle component analysis (PCoA) revealed the existence of three parasite subpopulations: (a) a small subpopulation of isolates from Aydin, western Turkey; (b) a second cluster predominantly generated by isolates from western Turkey; and (c) a third cluster predominantly formed by isolates from central and eastern Turkey. Two B. ovis isolates from Israel included in the analysis clustered with isolates from central and eastern Turkey. This finding strongly suggests substructuring of a major Turkish population into western versus central–eastern subpopulations, while the additional smaller B. ovis population found in Aydin could have been introduced, more recently, to Turkey. STRUCTURE analysis suggests a limited exchange of parasite strains between the western and the central–eastern regions and vice versa, possibly due to limited trading of sheep. Importantly, evidence for recombinant genotypes was obtained in regionally interchanged parasite isolates. Important climatic differences between the western and the central/eastern region, with average yearly temperatures of 21°C versus 15°C, correspond with the identified geographical substructuring. We hypothesize that the different climatic conditions may result in variation in the activity of subpopulations of Rhipicephalus spp. tick vectors, which, in turn, could selectively maintain and transmit different parasite populations. These findings may have important implications for vaccine development and the spread of drug resistance.eng
dc.formatapplication/pdfes_AR
dc.language.isoenges_AR
dc.publisherWileyes_AR
dc.relationinfo:eu-repograntAgreement/INTA/PNBIO/1131034/AR./Inmunología molecular y genómica funcional aplicadas a interacciones patógeno hospedador de interés pecuario.es_AR
dc.rightsinfo:eu-repo/semantics/openAccesses_AR
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.sourceTransboundary and Emerging Diseases 67 (Supl. 2) : 26-35 (Julio 2020)es_AR
dc.subjectBabesia ovises_AR
dc.subjectGenetic diversity (as resource)eng
dc.subjectDiversidad genética (como recurso)es_AR
dc.subjectMultilocus Sequence Typingeng
dc.subjectTipificación de Secuencias Multilocuses_AR
dc.subjectBabesiosises_AR
dc.subjectPopulation Structureeng
dc.subjectEstructura de la Poblaciónes_AR
dc.subjectSatellite DNAeng
dc.subjectADN Satélitees_AR
dc.subjectTurquíaes_AR
dc.subjectSheepeng
dc.subjectOvinoses_AR
dc.subjectGoatseng
dc.subjectCaprinoses_AR
dc.titleHigh genetic diversity and differentiation of the babesia ovis population in Turkeyes_AR
dc.typeinfo:ar-repo/semantics/artículoes_AR
dc.typeinfo:eu-repo/semantics/articlees_AR
dc.typeinfo:eu-repo/semantics/publishedVersiones_AR
dc.rights.licenseCreative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.description.origenInstituto de Patobiologíaes_AR
dc.description.filFil: Mira, Anabela. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes_AR
dc.description.filFil: Unlu, Ahmet Hakan. Van Yuzuncu Yil University. Vocational School of Gevas; Turquíaes_AR
dc.description.filFil: Bilgic, Huseyin Bilgin. Aydin Adnan Menderes University. Faculty of Veterinary Medicine. Department of Parasitology; Turquíaes_AR
dc.description.filFil: Bakirci, Serkan. Aydin Adnan Menderes University. Faculty of Veterinary Medicine. Department of Parasitology; Turquíaes_AR
dc.description.filFil: Hacilarlioglu, Selin. Aydin Adnan Menderes University. Faculty of Veterinary Medicine. Department of Parasitology; Turquíaes_AR
dc.description.filFil: Karagenc, Tulin. Aydin Adnan Menderes University. Faculty of Veterinary Medicine. Department of Parasitology; Turquíaes_AR
dc.description.filFil: Carletti, Tamara. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentinaes_AR
dc.description.filFil: Weir, William. Universityof Glasgow. College of Medical, Veterinary and Life Sciences; Reino Unidoes_AR
dc.description.filFil: Shiels, Brian. Universityof Glasgow. College of Medical, Veterinary and Life Sciences; Reino Unidoes_AR
dc.description.filFil: Shkap, Varda. Kimron Veterinary Institute. Division of Parasitology; Israeles_AR
dc.description.filFil: Aktas, Munir. Firat University. Faculty of Veterinary Medicine. Department of Parasitology; Turquíaes_AR
dc.description.filFil: Florin-Christensen, Monica. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes_AR
dc.description.filFil: Schnittger, Leonhard. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes_AR
dc.subtypecientifico


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