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Abstract
Background: Neonatal diarrhea remains one of the main causes of morbi-mortality in dairy calves under artificial rearing. It is often caused by infectious agents of viral, bacterial, or parasitic origin. Cows vaccination and colostrum intake by calves during the first 6 h of life are critical strategies to prevent severe diarrhea but these are still insufficient. Here we report the field evaluation of a product based on IgY antibodies against group A [ver mas...]
dc.contributor.authorVega, Celina Guadalupe
dc.contributor.authorBok, Marina
dc.contributor.authorEbinger, Maren
dc.contributor.authorRocha, Lucía Alejandra
dc.contributor.authorRivolta, Alejandra Antonella
dc.contributor.authorGonzález Thomas, Valeria
dc.contributor.authorMuntadas, Pilar
dc.contributor.authorD’Aloia, Ricardo
dc.contributor.authorPinto, Verónica
dc.contributor.authorParreño, Viviana
dc.contributor.authorWigdorovitz, Andres
dc.date.accessioned2020-08-05T16:54:58Z
dc.date.available2020-08-05T16:54:58Z
dc.date.issued2020-07
dc.identifier.issn1746-6148
dc.identifier.otherhttps://doi.org/10.1186/s12917-020-02476-3
dc.identifier.urihttp://hdl.handle.net/20.500.12123/7673
dc.identifier.urihttps://bmcvetres.biomedcentral.com/articles/10.1186/s12917-020-02476-3
dc.description.abstractBackground: Neonatal diarrhea remains one of the main causes of morbi-mortality in dairy calves under artificial rearing. It is often caused by infectious agents of viral, bacterial, or parasitic origin. Cows vaccination and colostrum intake by calves during the first 6 h of life are critical strategies to prevent severe diarrhea but these are still insufficient. Here we report the field evaluation of a product based on IgY antibodies against group A rotavirus (RVA), coronavirus (CoV), enterotoxigenic Escherichia coli, and Salmonella sp. This product, named IgY DNT, has been designed as a complementary passive immunization strategy to prevent neonatal calf diarrhea. The quality of the product depends on the titers of specific IgY antibodies to each antigen evaluated by ELISA. In the case of the viral antigens, ELISA antibody (Ab) titers are correlated with protection against infection in calves experimentally challenged with RVA and CoV (Bok M, et al., Passive immunity to control bovine coronavirus diarrhea in a dairy herd in Argentina, 2017), (Vega C, et al., Vet Immunol Immunopathol, 142:156–69, 2011), (Vega C, et al., Res Vet Sci, 103:1–10, 2015). To evaluate the efficiency in dairy farms, thirty newborn Holstein calves were randomly assigned to IgY DNT or control groups and treatment initiated after colostrum intake and gut closure. Calves in the IgY DNT group received 20 g of the oral passive treatment in 2 L of milk twice a day during the first 2 weeks of life. Animals were followed until 3 weeks of age and diarrhea due to natural exposure to infectious agents was recorded during all the experimental time. Results: Results demonstrate that the oral administration of IgY DNT during the first 2 weeks of life to newborn calves caused a delay in diarrhea onset and significantly reduced its severity and duration compared with untreated calves. Animals treated with IgY DNT showed a trend towards a delay in RVA infection with significantly shorter duration and virus shedding compared to control calves. Conclusions: This indicates that IgY DNT is an effective product to complement current preventive strategies against neonatal calf diarrhea in dairy farms. Furthermore, to our knowledge, this is the only biological product available for the prevention of virus-associated neonatal calf diarrhea.eng
dc.formatapplication/pdfes_AR
dc.language.isoenges_AR
dc.publisherBMCes_AR
dc.rightsinfo:eu-repo/semantics/openAccesses_AR
dc.sourceBMC Veterinary Research 16 : article number: 264 (2020)es_AR
dc.subjectGanado de Lechees_AR
dc.subjectDairy Cattleeng
dc.subjectEnfermedades de los Animaleses_AR
dc.subjectAnimal Diseaseseng
dc.subjectRespuesta Inmunológicaes_AR
dc.subjectImmune Responseeng
dc.subjectAnticuerposes_AR
dc.subjectAntibodieseng
dc.subjectRota Virus Diarrea de Terneroses_AR
dc.subjectCalf Diarrhoea Rotaviruseng
dc.subject.otherDiarrea Neonatales_AR
dc.titleA new passive immune strategy based on IgY antibodies as a key element to control neonatal calf diarrhea in dairy farmses_AR
dc.typeinfo:ar-repo/semantics/artículoes_AR
dc.typeinfo:eu-repo/semantics/articlees_AR
dc.typeinfo:eu-repo/semantics/publishedVersiones_AR
dc.description.origenCentro de Investigación en Ciencias Veterinarias y Agronómicases_AR
dc.description.filFil: Vega, Celina Guadalupe. Instituto Nacional de Tecnología Agropecuaria (INTA). Incuinta e Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Bioinnovo S.A.; Argentinaes_AR
dc.description.filFil: Bok, Marina. Instituto Nacional de Tecnología Agropecuaria (INTA). Incuinta e Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Bioinnovo S.A.; Argentinaes_AR
dc.description.filFil: Ebinger, Maren. El Mangrullo Farm; Argentinaes_AR
dc.description.filFil: Rocha, Lucía Alejandra. Instituto Nacional de Tecnología Agropecuaria (INTA). Incuinta e Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes_AR
dc.description.filFil: Rivolta, Alejandra Antonella. Instituto Nacional de Tecnología Agropecuaria (INTA). Incuinta e Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes_AR
dc.description.filFil: González Thomas, Valeria. Servicio Nacional de Sanidad y Calidad Agroalimentaria (SENASA); Argentinaes_AR
dc.description.filFil: Muntadas, Pilar. Servicio Nacional de Sanidad y Calidad Agroalimentaria (SENASA); Argentinaes_AR
dc.description.filFil: D’Aloia, Ricardo. Servicio Nacional de Sanidad y Calidad Agroalimentaria (SENASA); Argentinaes_AR
dc.description.filFil: Pinto, Verónica. Vetanco S.A.; Argentinaes_AR
dc.description.filFil: Parreño, Viviana. Instituto Nacional de Tecnología Agropecuaria (INTA). Incuinta e Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Bioinnovo S.A.; Argentinaes_AR
dc.description.filFil: Wigdorovitz, Andres. Instituto Nacional de Tecnología Agropecuaria (INTA). Incuinta e Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Bioinnovo S.A.; Argentinaes_AR
dc.subtypecientifico


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