Facebook
Twitter
YouTube
Instagram
    • español
    • English
  • Contacto
  • English 
    • español
    • English
  • Login
AboutAuthorsTitlesSubjectsCollectionsCommunities☰
JavaScript is disabled for your browser. Some features of this site may not work without it.
View Item 
    xmlui.general.dspace_homeCentros e Institutos de InvestigaciónCICVyA. Centro de Investigación en Ciencias Veterinarias y AgronómicasInstituto de PatobiologíaArtículos científicosxmlui.ArtifactBrowser.ItemViewer.trail
  • DSpace Home
  • Centros e Institutos de Investigación
  • CICVyA. Centro de Investigación en Ciencias Veterinarias y Agronómicas
  • Instituto de Patobiología
  • Artículos científicos
  • View Item

Vaccines against bovine babesiosis: where we are now and possible roads ahead

Abstract
Bovine babesiosis caused by the tick-transmitted haemoprotozoans Babesia bovis, Babesia bigemina and Babesia divergens commonly results in substantial cattle morbidity and mortality in vast world areas. Although existing live vaccines confer protection, they have considerable disadvantages. Therefore, particularly in countries where large numbers of cattle are at risk, important research is directed towards improved vaccination strategies. Here a [ver mas...]
Bovine babesiosis caused by the tick-transmitted haemoprotozoans Babesia bovis, Babesia bigemina and Babesia divergens commonly results in substantial cattle morbidity and mortality in vast world areas. Although existing live vaccines confer protection, they have considerable disadvantages. Therefore, particularly in countries where large numbers of cattle are at risk, important research is directed towards improved vaccination strategies. Here a comprehensive overview of currently used live vaccines and of the status quo of experimental vaccine trials is presented. In addition, pertinent research fields potentially contributing to the development of novel non-live and/or live vaccines are discussed, including parasite antigens involved in host cell invasion and in pathogen-tick interactions, as well as the protective immunity against infection. The mining of available parasite genomes is continuously enlarging the array of potential vaccine candidates and, additionally, the recent development of a transfection tool for Babesia can significantly contribute to vaccine design. However, the complication and high cost of vaccination trials hinder Babesia vaccine research, and have so far seriously limited the systematic examination of antigen candidates and prevented an in-depth testing of formulations using different immunomodulators and antigen delivery systems. [Cerrar]
Thumbnail
Author
Florin-Christensen, Mónica;   Suarez, Carlos Esteban;   Rodriguez, Anabel Elisa;   Flores, Daniela;   Schnittger, Leonhard;  
Fuente
Parasitology 141 (12) : 1563-1592 (Octubre 2014)
Date
2014-10
Editorial
Cambridge University Press
ISSN
1469-8161
URI
http://hdl.handle.net/20.500.12123/6712
https://www.cambridge.org/core/journals/parasitology/article/vaccines-against-bovine-babesiosis-where-we-are-now-and-possible-roads-ahead/AB57CCC9D2E129C420762F66D7A3DF33
DOI
https://doi.org/10.1017/S0031182014000961
Formato
pdf
Tipo de documento
artículo
Palabras Claves
Babesiosis; Live Vaccines; Vacuna Viva; Erythrocytes; Eritrocitos; Tick-borne Diseases; Enfermedades Transmitidas por Garrapatas; Immune Response; Respuesta Inmunológica; Cattle; Ganado Bovino;
Derechos de acceso
Restringido
Descargar
Compartir
  • Compartir
    Facebook Email Twitter Mendeley
Excepto donde se diga explicitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Metadata
Show full item record