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The aim of the present study was to characterize the specific immune response in prepubertal female calves inoculated with Neospora caninum. Forty-eight N. caninum-seronegative 6-month-old Angus female calves were randomly allocated into two groups: group A calves were inoculated subcutaneously (sc) with 1 × 106 tachyzoites of the low virulence NC-Argentina LP1 isolate in sterile phosphate-buffered saline (PBS); group B calves were mock inoculated sc with
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dc.contributor.author | Hecker, Yanina | |
dc.contributor.author | Regidor-Cerrillo, Javier | |
dc.contributor.author | Fiorani, Franco | |
dc.contributor.author | Horcajo, Pilar | |
dc.contributor.author | Soria, Ivana | |
dc.contributor.author | Gual, Ignacio | |
dc.contributor.author | Torioni, Susana Marta | |
dc.contributor.author | Campero, Lucia | |
dc.contributor.author | Echaide, Ignacio Eduardo | |
dc.contributor.author | Alvarez-García, Gema | |
dc.contributor.author | Ortega-Mora, Luis | |
dc.contributor.author | Zamorano, Patricia Ines | |
dc.contributor.author | Venturini, María Clara | |
dc.contributor.author | Odeon, Anselmo Carlos | |
dc.contributor.author | Canton, German Jose | |
dc.contributor.author | Moore, Prando Dadin | |
dc.date.accessioned | 2019-09-27T10:55:06Z | |
dc.date.available | 2019-09-27T10:55:06Z | |
dc.date.issued | 2019-09-04 | |
dc.identifier.issn | 0932-0113 (Print) | |
dc.identifier.issn | 1432-1955 (Online) | |
dc.identifier.other | https://doi.org/10.1007/s00436-019-06447-y | |
dc.identifier.uri | https://link.springer.com/article/10.1007%2Fs00436-019-06447-y | |
dc.identifier.uri | http://hdl.handle.net/20.500.12123/5993 | |
dc.description.abstract | The aim of the present study was to characterize the specific immune response in prepubertal female calves inoculated with Neospora caninum. Forty-eight N. caninum-seronegative 6-month-old Angus female calves were randomly allocated into two groups: group A calves were inoculated subcutaneously (sc) with 1 × 106 tachyzoites of the low virulence NC-Argentina LP1 isolate in sterile phosphate-buffered saline (PBS); group B calves were mock inoculated sc with sterile PBS. Calves from group A developed a specific immune response characterized by the production of IgG antibodies and the expression of IFN-γ and TNF-α cytokines. Animals did not present any febrile reaction or reactions at the site of inoculation. Although chronic N. caninum infection was developed in 50% of calves of group A after inoculation, according to the presence of antibodies against rNc-SAG4, antigen characteristic of bradyzoites, N. caninum antibodies dropped below the cut-off of ELISA from day 210 post-inoculation onwards. Future trials using the same group of inoculated animals will allow the characterization of the evolution of the immune response during pregnancy and to determine whether the immunization with the local isolate is able to prevent congenital transmission and to protect against heterologous challenges. | eng |
dc.format | application/pdf | es_AR |
dc.language.iso | eng | es_AR |
dc.publisher | Springer Berlin | es_AR |
dc.rights | info:eu-repo/semantics/restrictedAccess | es_AR |
dc.source | Parasitollogy Research 18 (10) : 2945-2955. (October 2019) | es_AR |
dc.subject | Neospora Caninum | es_AR |
dc.subject | Respuesta Inmunológica | es_AR |
dc.subject | Inmune Response | eng |
dc.subject | Inoculación | es_AR |
dc.subject | Inoculation | eng |
dc.subject | Ternero | es_AR |
dc.subject | Calves | eng |
dc.title | Immune response to Neospora caninum live tachyzoites in prepubertal female calves | es_AR |
dc.type | info:ar-repo/semantics/artículo | es_AR |
dc.type | info:eu-repo/semantics/article | es_AR |
dc.type | info:eu-repo/semantics/publishedVersion | es_AR |
dc.description.origen | EEA Balcarce | es_AR |
dc.description.fil | Fil: Hecker, Yanina. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. | es_AR |
dc.description.fil | Fil: Regidor-Cerrillo, Javier. Universidad de Madrid. Facultad de Ciencias Veterinarias; España. | es_AR |
dc.description.fil | Fil: Fiorani, Franco. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina. | es_AR |
dc.description.fil | Fil: Horcajo, Pilar. Universidad de Madrid. Facultad de Ciencias Veterinarias; España. | es_AR |
dc.description.fil | Fil: Soria, Ivana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación de Virología; Argentina. | es_AR |
dc.description.fil | Fil: Gual, Ignacio. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. | es_AR |
dc.description.fil | Fil: Torioni, Susana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación de Virología; Argentina. | es_AR |
dc.description.fil | Fil: Campero, Lucia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata, Facultad de Medicina Veterinaria; Argentina. | es_AR |
dc.description.fil | Fil: Echaide, Ignacio. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación de Virología; Argentina. | es_AR |
dc.description.fil | Fil: Alvarez- García, Gema. Universidad de Madrid. Facultad de Ciencias Veterinarias; España. | es_AR |
dc.description.fil | Fil: Ortega-Mora, Luis. Universidad de Madrid. Facultad de Ciencias Veterinarias; España. | es_AR |
dc.description.fil | Fil: Zamorano, Patricia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. | es_AR |
dc.description.fil | Fil: Venturini, María Clara. Universidad Nacional de La Plata, Facultad de Medicina Veterinaria; Argentina. | es_AR |
dc.description.fil | Fil: Odeón, Anselmo Carlos. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina. | es_AR |
dc.description.fil | Fil: Cantón, Germán José. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina. | es_AR |
dc.description.fil | Fil: Moore, Dadín. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina | es_AR |
dc.subtype | cientifico |
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