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    • Characterization of GASA-1, a new vaccine candidate antigen of Babesia bovis 

      Flores, Daniela; Rodriguez, Anabel Elisa; Tomazic, Mariela Luján; Torioni, Susana Marta; Echaide, Ignacio Eduardo; Zamorano, Patricia Ines; Langellotti, Cecilia Ana; Araujo, Flabio Ribeiro de; Rolls, Peter; Schnittger, Leonhard; Florin-Christensen, Mónica (Elsevier, 2020-11)
      Surface proteins bound to the cell membrane by glycosylphosphatidylinositol (GPI) anchors are considered essential for the survival of pathogenic protozoans. In the case of the tick-transmitted hemoparasite Babesia bovis, ...

    • Degrade to survive : the intricate world of piroplasmid proteases 

      Florin-Christensen, Mónica; Sojka, Daniel; Ganzinelli, Sabrina Belen; Snebergerová, Pavla; Suarez, Carlos Esteban; Schnittger, Leonhard (Elsevier, 2023-07)
      Piroplasmids of the genera Babesia, Theileria, and Cytauxzoon are tick-transmitted parasites with a high impact on animals and humans. They have complex life cycles in their definitive arthropod and intermediate vertebrate ...

    • Evaluation of the safety profile of the vaccine candidate Brucella melitensis 16MDvjbR strain in goats 

      Castaño Zubieta, Mirta Raquel; Rossetti, Carlos Alberto; Garcia-Gonzalez, Daniel G.; Maurizio, Estefanía; Hensel, Martha E.; Rice-Ficht, Allison C.; Ficht, Thomas A.; Arenas-Gamboa, Angela M. (Elsevier, 2021-01)
      Small ruminant brucellosis is caused by the Gram negative cocci-bacillus Brucella (B.) melitensis, the most virulent Brucella species for humans. In goats and sheep, middle to late-term gestation abortion, stillbirths and ...

    • Identification of novel vaccine candidates against cryptosporidiosis of neonatal bovines by reverse vaccinology 

      Tomazic, Mariela Luján; Rodriguez, Anabel Elisa; Lombardelli Joaquín Andrés; Poklepovich Caride, Tomás Javier; Garro, Carlos Javier; Galarza, Roxana Ivon; Tiranti, Karina; Florin-Christensen, Mónica; Schnittger, Leonhard (Elsevier, 2018-12)
      The apicomplexan protozoan Cryptosporidium parvum is an important causative agent of diarrhea of neonatal bovines. Vaccination has been proposed as an advantageous strategy against cryptosporidiosis of calves since besides ...

    • New scenarios for brucella suis and brucella melitensis 

      Samartino, Luis Ernesto; Arregui, Matias Ezequiel; Martino, Pablo Eduardo (Springer, 2017-03)
      Purpose of Review: We pretend to highlight the most important advances reached in the last few years in the biology of Brucella suis and Brucella melitensis and focus attention on new tools for the comprehension, prevention ...

    • Next-generation technologies and systems biology for the design of novel vaccines against apicomplexan parasites 

      Tomazic, Mariela Luján; Marugán-Hernandez, Virginia; Rodriguez, Anabel Elisa (Frontiers Media, 2022-01)
      Parasites of the phylum Apicomplexa are the causative agents of important diseases such as malaria, toxoplasmosis or cryptosporidiosis in humans, and babesiosis and coccidiosis in animals. Whereas the first human recombinant ...

    • Plant-based vaccine for livestock : key points to unleash platform translation in developing countries 

      Perez Aguirreburualde, Maria Sol; Petruccelli, Silvana; Bravo Almonacid, Fernando Felix; Wigdorovitz, Andres (2016-12)
      Ten years ago the first plant-based vaccine was licensed (DowAgrosciences). It was only 20 years after the first report of a recombinant protein obtained through plant transformation technology. Back then, this vaccine was ...

    • A recombinant multi-antigen vaccine formulation containing Babesia bovis merozoite surface antigens MSA-2a1, MSA- 2b and MSA-2c elicits invasion-inhibitory antibodies and IFN-γ producing cells 

      Gimenez, Alba Marina; Françoso, Katia S.; Ersching, Jonatan; Icimoto, Marcelo Y.; Oliveira, Vitor; Rodriguez, Anabel Elisa; Schnittger, Leonhard; Florin-Christensen, Mónica; Rodrigues, Mauricio M.; Soares, Irene S. (2016)
      Background: Babesia bovis is a tick-transmitted protozoan hemoparasite and the causative agent of bovine babesiosis, a potential risk to more than 500 million cattle worldwide. The vaccines currently available are based ...