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A simple and economic three-step process for producing highly purified Fab’ fragments directly from the egg yolk water-soluble fraction
(Elsevier, 2022-11)Although mammals are still the main source of polyclonal antibodies production, the use of egg yolk immunoglobulins (IgY) is increasing, and thus improvement of its safety to reduce undesired reactions is needed. Removal ... -
Babesia bovis AMA-1, MSA-2c and RAP-1 contain conserved B and T-cell epitopes, which generate neutralizing antibodies and a long-lasting Th1 immune response in vaccinated cattle
(Elsevier, 2022-02)Vaccines against bovine babesiosis must, ideally, induce a humoral immune response characterized by neutralizing antibodies against conserved epitopes and a cellular Th1 immune response. In Babesia bovis, proteins such as ... -
Characterization of innate immune response to Brucella melitensis infection in goats with permissive or restrictive phenotype for Brucella intramacrophagic growth
(Elsevier, 2021-04)Caprine brucellosis is a chronic, world-wide distributed disease which causes reproductive failure in goats and Brucella melitensis, its causative agent, bears a great zoonotic potential. There is evidence suggesting that ... -
IgY-technology (egg yolk antibodies) in human medicine: a review of patents and clinical trials
(Elsevier, 2020-04)IgY-technology (the production and extraction of specific IgY antibodies from egg yolk) is an innovative method to produce antibodies for therapy and prophylaxis. Advantages of IgY over other antibodies comprise its ... -
Immunization of pregnant cows with Shiga toxin-2 induces high levels of specific colostral antibodies and lactoferrin able to neutralize E. coli O157:H7 pathogenicity
(2018-03)E. coli O157:H7 is a foodborne pathogen responsible for bloody diarrhea, hemorrhagic colitis and hemolytic uremic syndrome (HUS). The objective of the present work was to evaluate the ability of colostral IgG obtained from ... -
In vitro inhibitory activity of IgY antibodies against Salmonella ser. newport isolated from horses
(Elsevier, 2021-08)Equine salmonellosis is caused by several Salmonella serotypes, including Salmonella Newport, which cause enterocolitis and diarrhea. Treatment usually includes the administration of antibiotics. However, since multidrug-resistant ... -
In vivo neutralization of bee venom lethality by IgY antibodies
(Elsevier, 2021-07)Bee venom is a complex mixture of molecules, among which melittin and phospholipase A2 (PLA2) are the toxic components involved in envenoming accidents with multiple honeybee stings. Traditionally, the treatment of envenomings ... -
Kinetic characterization of a novel cysteine peptidase from the protozoan Babesia bovis, a potential target for drug design
(Elsevier, 2020-12)C1A cysteine peptidases have been shown to play an important role during apicomplexan invasion and egress of host red blood cells (RBCs) and therefore have been exploited as targets for drug development, in which peptidase ... -
New enzyme-linked immunoassay for the detection of specific antibodies against multiple Leptospira serogroups in bovine sera
(Elsevier, 2021-04)Leptospirosis is a zoonotic disease with worldwide endemicity in Argentina, it is a significant public health problem in low-income populations. Bovine leptospirosis is a serious economic problem for cattle production, ... -
Physiopathological effects of Escherichia coli O157:H7 inoculation in weaned calves fed with colostrum containing antibodies to EspB and Intimin
(Elsevier, 2014-06-24)Escherichia coli O157:H7 is responsible for severe intestinal disease and hemolytic uremic syndrome (HUS), a serious systemic complication which particularly affects children. Cattle are the primary reservoir for E. coli ... -
A recombinant multi-antigen vaccine formulation containing Babesia bovis merozoite surface antigens MSA-2a1, MSA- 2b and MSA-2c elicits invasion-inhibitory antibodies and IFN-γ producing cells
(2016)Background: Babesia bovis is a tick-transmitted protozoan hemoparasite and the causative agent of bovine babesiosis, a potential risk to more than 500 million cattle worldwide. The vaccines currently available are based ... -
Seroprevalence for selected pathogens of zoonotic importance in wild nutria (Myocastor coypus)
(Springer, 2014-06)Little information is present in the literature on diseases of the nutria (Myocastor coypus) in the wild. Serum samples obtained from 176 trapped animals were tested for antibody reactivity against 11 pathogens of significant ... -
Use of adjuvant ISA VG 71 to produce neutralizing egg yolk antibodies against bothropic venom
(Springer, 2023-02)The use of egg yolk antibodies—IgY technology—represents an alternative to the production of mammalian immunoglobulins and has several advantages regarding animal welfare and lower costs of production. The use of adjuvants ...