Mostrar el registro sencillo del ítem
resumen
Resumen
Neospora caninum infection of cattle can be vertically transmitted, resulting in abortion or birth of infected
calves. Vertical transmission occurs both in acutely or chronically infected cattle. There is little information on
the immune response needed to prevent endogenous transplacental transmission, particularly from chronically
infected cattle to their offspring in a natural environment. In this study, N. caninum seropositive pregnant cattle
from
[ver mas...]
dc.contributor.author | Pereyra, Walter Rodrigo | |
dc.contributor.author | Mansilla, Florencia Celeste | |
dc.contributor.author | Petersen, Marcos Iván | |
dc.contributor.author | Suarez, Victor Humberto | |
dc.contributor.author | Capozzo, Alejandra Victoria | |
dc.date.accessioned | 2019-02-07T15:38:44Z | |
dc.date.available | 2019-02-07T15:38:44Z | |
dc.date.issued | 2019-02 | |
dc.identifier.issn | 0165-2427 | |
dc.identifier.other | https://doi.org/10.1016/j.vetimm.2019.01.001 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12123/4403 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0165242718303933?via%3Dihub | |
dc.description.abstract | Neospora caninum infection of cattle can be vertically transmitted, resulting in abortion or birth of infected calves. Vertical transmission occurs both in acutely or chronically infected cattle. There is little information on the immune response needed to prevent endogenous transplacental transmission, particularly from chronically infected cattle to their offspring in a natural environment. In this study, N. caninum seropositive pregnant cattle from three different farms with high avidity antibodies and low IgM titers were selected and their newborn colostrum-deprived calves were tested for anti-N. caninum antibodies. Based on these results, dams were grouped according to their congenital transmission status. The analysis of the immune profile of the chronically-infected pregnant cattle revealed that higher ratio between IgG1 and IgG2 anti-N. caninum serum titers and higher levels of systemic IFN-γ were associated with diminished vertical transmission rates, compared to dams with the opposite profile. Our results evidenced an association between the immune profile and vertical transmission in nonaborting chronically infected dams, and confirm that vertical transmission, even when not leading to abortion, is related to a defined immune profile. This is important information to accomplish successful vaccine development efforts. | es_AR |
dc.format | application/pdf | eng |
dc.language.iso | spa | |
dc.publisher | Elsevier | eng |
dc.rights | info:eu-repo/semantics/restrictedAccess | eng |
dc.source | Veterinary immunology and immunopathology 208 : 53-57. (February 2019) | eng |
dc.subject | Neospora Caninum | es_AR |
dc.subject | Infection | eng |
dc.subject | Infección | es_AR |
dc.subject | Immune Response | eng |
dc.subject | Respuesta Inmunológica | es_AR |
dc.subject | Bovinae | eng |
dc.subject | Bovina | es_AR |
dc.subject | Vertical Transmission | eng |
dc.subject | Transmisión de Enfermedades | es_AR |
dc.subject | Disease Transmission | eng |
dc.subject.other | Transplacental Transmission | eng |
dc.subject.other | Chronic Infection | eng |
dc.subject.other | IgG Subtypes | eng |
dc.title | Evidence of reduced vertical transmission of Neospora caninum associated with higher IgG1 than IgG2 serum levels and presence of IFN-γ in nonaborting chronically infected cattle under natural condition | eng |
dc.type | info:ar-repo/semantics/artículo | es_AR |
dc.type | info:eu-repo/semantics/article | eng |
dc.type | info:eu-repo/semantics/publishedVersion | eng |
dc.description.origen | EEA Salta | es_AR |
dc.description.fil | Fil: Pereyra, Walter Rodrigo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal Chaco Semiarido. Grupo de Patología, Epidemiología e Investigación Diagnóstica-Área de Sanidad Animal; Argentinaía General y Especial; Argentina | es_AR |
dc.description.fil | Fil: Mansilla, Florencia Celeste. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina | es_AR |
dc.description.fil | Fil: Petersen, Marcos Ivan. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina | es_AR |
dc.description.fil | Fil: Suarez, Victor Humberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal Chaco Semiarido. Grupo de Patología, Epidemiología e Investigación Diagnóstica-Área de Sanidad Animal; Argentinaía General y Especial; Argentina | es_AR |
dc.description.fil | Fil: Capozzo, Alejandra Victoria. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina | es_AR |
dc.subtype | cientifico |
Ficheros en el ítem
Este ítem aparece en la(s) siguiente(s) colección(ones)
common
-
Artículos científicos [103]