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Abstract
This study evaluates the influence of immunizing lambs with the incomplete S48 strain of Toxoplasma gondii, on parasite dissemination following a live oral challenge with a complete strain of T. gondii (M4). Lambs were culled at 14, 28 and 42 days post challenge. Parasite DNA was detected at significantly (p < 0.0001) lower levels in samples from the vaccinated/challenged group (0% in heart and 5.9% in skeletal muscles), when compared to the [ver mas...]
dc.contributor.authorKatzer, Frank
dc.contributor.authorCanton, German Jose
dc.contributor.authorBurrels, Alison
dc.contributor.authorPalarea-Albaladejo, Javier
dc.contributor.authorHorton, Ben
dc.contributor.authorBartley, Paul M.
dc.contributor.authorPang, Yvonne
dc.contributor.authorChianini, Francesca
dc.contributor.authorInnes, Elisabeth A.
dc.contributor.authorBenavides-Silván, Julio
dc.date.accessioned2019-02-01T12:16:51Z
dc.date.available2019-02-01T12:16:51Z
dc.date.issued2014-09-15
dc.identifier.issn0304-4017
dc.identifier.otherhttps://doi.org/10.1016/j.vetpar.2014.07.003
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0304401714003884
dc.identifier.urihttp://hdl.handle.net/20.500.12123/4372
dc.description.abstractThis study evaluates the influence of immunizing lambs with the incomplete S48 strain of Toxoplasma gondii, on parasite dissemination following a live oral challenge with a complete strain of T. gondii (M4). Lambs were culled at 14, 28 and 42 days post challenge. Parasite DNA was detected at significantly (p < 0.0001) lower levels in samples from the vaccinated/challenged group (0% in heart and 5.9% in skeletal muscles), when compared to the non-vaccinated/challenged animals (75% heart, 87.9% skeletal muscle). S48 T. gondii DNA was found in muscle or lymph nodes until 42 days post infection, suggesting that parasite DNA or tachyzoites could persist longer after immunization than previously thought. Non-vaccinated/challenged animals showed more frequent lesions in muscles and central nervous system than the vaccinated animals. These results demonstrate that vaccination of lambs with the incomplete S48 T. gondii strain, can protect against establishment of tissue cysts following challenge with a complete strain of T. gondii. Consumption of undercooked meat containing T. gondii cysts is a major route of transmission to people, therefore vaccination of food animals may improve the safety of meat for human consumption.eng
dc.formatapplication/pdfes_AR
dc.language.isoenges_AR
dc.publisherElsevieres_AR
dc.rightsinfo:eu-repo/semantics/restrictedAccesses_AR
dc.sourceVeterinary Parasitology 205 (1–2) : 46-56 (September 2014)es_AR
dc.subjectCorderoes_AR
dc.subjectLambseng
dc.subjectInmunizaciónes_AR
dc.subjectImmunizationeng
dc.subjectToxoplasma gondiies_AR
dc.subjectVacunaes_AR
dc.subjectVaccineseng
dc.subjectToxoplasmosises_AR
dc.subjectZoonosises_AR
dc.subjectZoonoseseng
dc.titleImmunization of lambs with the S48 strain of Toxoplasma gondii reduces tissue cyst burden following oral challenge with a complete strain of the parasitees_AR
dc.typeinfo:ar-repo/semantics/artículoes_AR
dc.typeinfo:eu-repo/semantics/articlees_AR
dc.typeinfo:eu-repo/semantics/publishedVersiones_AR
dc.description.origenEEA Balcarcees_AR
dc.description.filFil: Katzer, Frank. Moredun Research Institute; Reino Unidoes_AR
dc.description.filFil: Canton, German Jose. Moredun Research Institute; Reino Unido. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentinaes_AR
dc.description.filFil: Burrels, Alison. Moredun Research Institute; Reino Unidoes_AR
dc.description.filFil: Palarea-Albaladejo, Javier. Biomathematics & Statistics Scotland; Reino Unidoes_AR
dc.description.filFil: Horton, Ben. Moredun Research Institute; Reino Unidoes_AR
dc.description.filFil: Bartley, Paul M. Moredun Research Institute; Reino Unidoes_AR
dc.description.filFil: Pang, Yvonne. Moredun Research Institute; Reino Unidoes_AR
dc.description.filFil: Chianini, Francesca. Moredun Research Institute; Reino Unidoes_AR
dc.description.filFil: Innes, Elisabeth A. Moredun Research Institute; Reino Unidoes_AR
dc.description.filFil: Benavides-Silván, Julio. Consejo Superior de Investigaciones Científicas. Instituto de Ganadería de Montaña; Españaes_AR
dc.subtypecientifico


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