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Abstract
Neospora caninum is recognized as a major cause of reproductive losses worldwide but its pathogenesis is not completely understood. Immune mediated placental pathology has been reported as being responsible for compromising pregnancy probably due to the adverse effects of exacerbated Th1 type response at the maternal–foetal interface. Different clinical outcomes are known to occur following experimental infections of cattle at different stages of [ver mas...]
dc.contributor.authorCanton, German Jose
dc.contributor.authorKatzer, Frank
dc.contributor.authorMaley, Stephen W.
dc.contributor.authorBartley, Paul M.
dc.contributor.authorBenavides-Silván, Julio
dc.contributor.authorPalarea-Albaladejo, Javier
dc.contributor.authorPang, Yvonne
dc.contributor.authorSmith, Sionagh
dc.contributor.authorRocchi, Mara
dc.contributor.authorBuxton, David
dc.contributor.authorInnes, Elisabeth A.
dc.contributor.authorChianini, Francesca
dc.date.accessioned2019-02-01T11:54:30Z
dc.date.available2019-02-01T11:54:30Z
dc.date.issued2014-09-15
dc.identifier.issn0165-2427
dc.identifier.issn1873-2534
dc.identifier.otherhttps://doi.org/10.1016/j.vetimm.2014.07.004
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0165242714001676
dc.identifier.urihttp://hdl.handle.net/20.500.12123/4371
dc.description.abstractNeospora caninum is recognized as a major cause of reproductive losses worldwide but its pathogenesis is not completely understood. Immune mediated placental pathology has been reported as being responsible for compromising pregnancy probably due to the adverse effects of exacerbated Th1 type response at the maternal–foetal interface. Different clinical outcomes are known to occur following experimental infections of cattle at different stages of gestation, with foetal death being the most common finding during early gestation, and the birth of live congenitally infected calves following infection later in gestation. The aim of the current study was to characterize the cytokine expression in the placenta of cattle experimentally challenged with tachyzoites of the Nc-1 strain during early, mid and late gestation. Moderate to severe infiltration of IL-12, IFN-γ and TNF-α expressing cells was observed in the placentas collected at early gestation and this infiltration was more pronounced in the samples collected from challenged dams carrying non-viable foetuses, compared with the mothers carrying viable foetuses. In contrast, the infiltration of Th1 cytokine expressing-cells was mild following N. caninum infection in mid gestation and scarce during infection in late gestation. Scarce expression of IL-4 was observed in the placentas from N. caninum-challenged and negative control animals throughout gestation. The milder Th1 immune response observed during later stages of gestation following Nc-1 infection could partially explain the less severe clinical outcome when compared to early pregnancy.eng
dc.formatapplication/pdfes_AR
dc.language.isoenges_AR
dc.publisherElsevieres_AR
dc.rightsinfo:eu-repo/semantics/restrictedAccesses_AR
dc.sourceVeterinary Immunology and Immunopathology 161 (1–2) : 77-89 (September 2014)es_AR
dc.subjectGanado Bovinoes_AR
dc.subjectCattleeng
dc.subjectNeospora caninumes_AR
dc.subjectGestaciónes_AR
dc.subjectPregnancyeng
dc.subjectEnfermedades de los Animaleses_AR
dc.subjectAnimal Diseaseseng
dc.subjectCitoquinases_AR
dc.subjectCytokineseng
dc.subjectPlacentaes_AR
dc.titleCytokine expression in the placenta of pregnant cattle after inoculation with Neospora caninumes_AR
dc.typeinfo:ar-repo/semantics/artículoes_AR
dc.typeinfo:eu-repo/semantics/articlees_AR
dc.typeinfo:eu-repo/semantics/publishedVersiones_AR
dc.description.origenEEA Balcarcees_AR
dc.description.filFil: Canton, German Jose. Moredun Research Institute; Reino Unido. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentinaes_AR
dc.description.filFil: Katzer, Frank. Moredun Research Institute; Reino Unidoes_AR
dc.description.filFil: Maley, Stephen W. Moredun Research Institute; Reino Unidoes_AR
dc.description.filFil: Bartley, Paul M. Moredun Research Institute; Reino Unidoes_AR
dc.description.filFil: Benavides-Silván, Julio. Moredun Research Institute; Reino Unido. Consejo Superior de Investigaciones Científicas. Instituto de Ganadería de Montaña; Españaes_AR
dc.description.filFil: Palarea-Albaladejo, Javier. Biomathematics & Statistics Scotland; Reino Unidoes_AR
dc.description.filFil: Pang, Yvonne. Moredun Research Institute; Reino Unidoes_AR
dc.description.filFil: Smith, Sionagh. University of Edinburgh. Royal (Dick) School of Veterinary Studies and Roslin Institute; Reino Unidoes_AR
dc.description.filFil: Rocchi, Mara. Moredun Research Institute; Reino Unidoes_AR
dc.description.filFil: Buxton, David. Moredun Research Institute; Reino Unidoes_AR
dc.description.filFil: Innes, Elisabeth A. Moredun Research Institute; Reino Unidoes_AR
dc.description.filFil: Chianini, Francesca. Moredun Research Institute; Reino Unidoes_AR
dc.subtypecientifico


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