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A Neospora caninum vaccine using recombinant proteins fails to prevent foetal infection in pregnant cattle after experimental intravenous challenge
(Elsevier, 2014-12-15)The aim of the present study was to evaluate the immunogenicity and protective efficacy of rNcSAG1, rNcHSP20 and rNcGRA7 recombinant proteins formulated with immune stimulating complexes (ISCOMs) in pregnant heifers against ... -
Characterization of Immune Cell Infiltration in the Placentome of Water Buffaloes (Bubalus bubalis) Infected with Neospora caninum During Pregnancy
(Elsevier, 2014-05)Neospora caninum infection in cattle stimulates host immune responses, which may be responsible for placental damage leading to abortion. Susceptibility of water buffaloes (Bubalus bubalis) to neosporosis is not well ... -
Cytokine expression in the placenta of pregnant cattle after inoculation with Neospora caninum
(Elsevier, 2014-09-15)Neospora caninum is recognized as a major cause of reproductive losses worldwide but its pathogenesis is not completely understood. Immune mediated placental pathology has been reported as being responsible for compromising ... -
High rate of transplacental infection and transmission of Neospora caninum following experimental challenge of cattle at day 210 of gestation
(BMC, 2012-12)In order to investigate the pathogenesis of neosporosis following a primary infection in late pregnancy, cattle were subcutaneously challenged with 5 × 108 Neospora caninum (NC1 isolate) tachyzoites at day 210 of gestation ... -
Immunization with inactivated antigens of Neospora caninum induces tolllike receptors 3, 7, 8 and 9 in maternal-fetal interface of infected pregnant heifers
(2017)Neospora caninum is an obligate parasite and a major cause of abortion in cattle. Pregnancy failures appear to be associated with weak innate defences on the maternal-fetal interface during infection with N. caninum. Herein, ... -
Inflammatory infiltration into placentas of Neospora caninum challenged cattle correlates with clinical outcome of pregnancy
(BMC, 2014-01)Infection with Neospora caninum stimulates host cell-mediated immune responses, which may be responsible for placental damage leading to bovine abortion. The aim of this study was to compare immune responses in the bovine ... -
Pathogenicity of Nc-Bahia and Nc-1 strains of Neospora caninum in experimentally infected cows and buffaloes in early pregnancy
(Springer, 2014-04)Neospora caninum is a protozoan parasite known as an important cause of bovine abortion worldwide. Little is currently known about how different strains of N. caninum vary in their pathogenicity. In this study, we compared ... -
Phenotypic characterisation of the cellular immune infiltrate in placentas of cattle following experimental inoculation with Neospora caninum in late gestation
(BMC, 2013-07)Despite Neospora caninum being a major cause of bovine abortion worldwide, its pathogenesis is not completely understood. Neospora infection stimulates host cell-mediated immune responses, which may be responsible for the ...