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Cathelicidin modulates synthesis of Toll-like Receptors (TLRs) 4 and 9 in colonic epithelium
Marín, Maia Solange; Holani, Ravi; Shah, Chaitanya B.; Odeon, Anselmo Carlos; Cobo, Eduardo Rubén (2017-11)Cathelicidin are innate antimicrobial peptides with broad immunomodulatory functions; however, their role in regulating intestinal defenses is not well characterized. This study aimed to investigate the role of cathelicidin ... -
Delayed-type hypersensitivity skin test against Neospora caninum in heifers with undetectable specific antibodies
Fiorani, Franco; Hecker, Yanina; Cirone, Karina Mariela; Armendano, Joaquín Ignacio; Gual, Ignacio; Campero, Lucía María; Wilkowsky, Silvina Elizabeth; Cobo, Eduardo Rubén; Corva, Pablo; Morrell, Eleonora Lidia; Canton, German Jose; Moore, Prando Dadin (Elsevier, 2020-07-19)Delayed-type hypersensitivity (DTH) has been used in human and veterinary medicine as a skin testing for evaluating in vivocell-mediated immune responses (CMIR). Whereas CMIR is a key process to control intracellular ... -
Immunization with inactivated antigens of Neospora caninum induces tolllike receptors 3, 7, 8 and 9 in maternal-fetal interface of infected pregnant heifers
Marin, Maia Solange; Hecker, Yanina Paola; Quintana, Silvina; Leunda, Maria Rosa; Canton, German Jose; Cobo, Eduardo Rubén; Moore, Prando Dadin; Odeon, Anselmo Carlos; Perez, Sandra (2017)Neospora caninum is an obligate parasite and a major cause of abortion in cattle. Pregnancy failures appear to be associated with weak innate defences on the maternal-fetal interface during infection with N. caninum. Herein, ... -
Modulation of cathelicidins, IFNβ and TNFα by bovine alpha-herpesviruses is dependent on the stage of the infectious cycle
Burucúa, Mercedes María; Quintana, Silvina; Lendez, Pamela Anahí; Cobo, Eduardo Rubén; Ceriani, María Carolina; Dolcini, Guillermina Laura; Odeon, Anselmo Carlos; Pérez, Sandra Elizabeth; Marin, Maia Solange (Elsevier, 2019-07)Production of antimicrobial peptides cathelicidins, interferons and cytokines is an important feature in airway epithelial host defense. The innate immune response to alpha-herpesvirus infection at the sites of primary ...