Mostrar el registro sencillo del ítem
resumen
Resumen
Bovine tuberculosis is a contagious infectious disease that causes significant economic impact in dairy and meat farms throughout the world. Multiple factors, including host genome, determine the outcome of the infection. Several studies have associated polymorphisms at the two microsatellites (Ms) -Ms1 and Ms2- at the 3´unstranslated (UTR) region of the SLC11A1 bovine gene with innate resistance or susceptibility to some facultative intracellular
[ver mas...]
dc.contributor.author | Hasenauer, Flavia Carolina | |
dc.contributor.author | Garbaccio, Sergio Gabriel | |
dc.contributor.author | Caffaro, María Eugenia | |
dc.contributor.author | Garro, Carlos Javier | |
dc.contributor.author | Huertas, Pablo Sebastian | |
dc.contributor.author | Poli, Mario Andres | |
dc.contributor.author | Rossetti, Carlos Alberto | |
dc.date.accessioned | 2018-06-04T13:38:52Z | |
dc.date.available | 2018-06-04T13:38:52Z | |
dc.date.issued | 2018-04 | |
dc.identifier.issn | 1871-1413 | |
dc.identifier.other | https://doi.org/10.1016/j.livsci.2018.01.012 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S1871141318300192 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12123/2539 | |
dc.description.abstract | Bovine tuberculosis is a contagious infectious disease that causes significant economic impact in dairy and meat farms throughout the world. Multiple factors, including host genome, determine the outcome of the infection. Several studies have associated polymorphisms at the two microsatellites (Ms) -Ms1 and Ms2- at the 3´unstranslated (UTR) region of the SLC11A1 bovine gene with innate resistance or susceptibility to some facultative intracellular bacterial infections, such as Brucella abortus and Mycobacterium avium subsp. paratuberculosis. Today, the few studies that investigated the association of those polymorphisms with innate resistance or susceptibility to tuberculosis in cattle, have shown opposite results. The aim of this study was to evaluate the role, if any, of the Ms1 and/or Ms2 polymorphisms at the 3´UTR of the SLC11A1 gene in Mycobacterium bovis infection phenotypes in Bos taurus dairy cattle. Jersey (n = 149) and Holstein (n = 427) cattle under risk of natural M. bovis infection were classified like controls (n = 326) and cases (n = 250) based on the response to caudal fold tuberculin skin test. Cattle population was genotyped by capillary electrophoresis based on polymorphisms in Ms1 and Ms2 at the 3´UTR SLC11A1 gene. The results presented here showed a lack of association (p > .05) between polymorphisms at the 3´UTR SLC11A1 gene and the response to tuberculin skin test in dairy Bos taurus cattle. Further studies are necessary to establish robustly genes or genome regions determining the innate R/S phenotype to Mycobacterium bovis. | eng |
dc.format | application/pdf | eng |
dc.language.iso | eng | |
dc.rights | info:eu-repo/semantics/restrictedAccess | eng |
dc.source | Livestock science 210 : 1-7. (April 2018) | eng |
dc.subject | Ganado de Leche | es_AR |
dc.subject | Dairy Cattle | eng |
dc.subject | Enfermedades de los Animales | es_AR |
dc.subject | Animal Diseases | eng |
dc.subject | Microsatélites | es_AR |
dc.subject | Microsatellites | eng |
dc.subject | Bos Taurus | es_AR |
dc.subject | Resistencia a la Enfermedad | es_AR |
dc.subject | Disease Resistance | eng |
dc.subject | Tuberculosis | es_AR |
dc.title | Exploring the association between polymorphisms at 3’UTR SLC11A1 gene microsatellites and resistance to tuberculosis: A case-control study in Bos taurus dairy cattle | es_AR |
dc.type | info:ar-repo/semantics/artículo | es_AR |
dc.type | info:eu-repo/semantics/article | eng |
dc.type | info:eu-repo/semantics/publishedVersion | eng |
dc.description.origen | Instituto de Patobiología | es_AR |
dc.description.fil | Fil: Hasenauer, Flavia Carolina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es_AR |
dc.description.fil | Fil: Garbaccio, Sergio Gabriel. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina | es_AR |
dc.description.fil | Fil: Caffaro, María Eugenia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina | es_AR |
dc.description.fil | Fil: Garro, Carlos Javier. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina | es_AR |
dc.description.fil | Fil: Huertas, Pablo Sebastian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina | es_AR |
dc.description.fil | Fil: Poli, Mario Andres. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina | es_AR |
dc.description.fil | Fil: Rossetti, Carlos Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina | es_AR |
dc.subtype | cientifico |
Ficheros en el ítem
Este ítem aparece en la(s) siguiente(s) colección(ones)
common
-
Artículos científicos [172]