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Abstract
Sodium fluoroacetate is an organofluorine compound toxic to mammals, insects, and birds, currently registered for use only in livestock protection collars as a predacide in some North American states, with restricted use in California. A flock of 445 lambs and ewes in California were moved into a native pasture on a municipal refuse disposal site. Within 24 hours, 14 ewes were found dead, and the remaining sheep were moved off the site. Both ewes and [ver mas...]
dc.contributor.authorGiannitti, Federico
dc.contributor.authorAnderson, Mark
dc.contributor.authorCaspe, Sergio Gaston
dc.contributor.authorMete, A.
dc.contributor.authorEast, N.E.
dc.contributor.authorMostrom, M.
dc.contributor.authorPoppenga, R.
dc.date.accessioned2018-05-23T14:04:22Z
dc.date.available2018-05-23T14:04:22Z
dc.date.issued2013-11
dc.identifier.issn0300-9858
dc.identifier.issn1544-2217
dc.identifier.otherhttps://doi.org/10.1177/0300985813486813
dc.identifier.urihttp://journals.sagepub.com/doi/abs/10.1177/0300985813486813?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
dc.identifier.urihttp://hdl.handle.net/20.500.12123/2464
dc.description.abstractSodium fluoroacetate is an organofluorine compound toxic to mammals, insects, and birds, currently registered for use only in livestock protection collars as a predacide in some North American states, with restricted use in California. A flock of 445 lambs and ewes in California were moved into a native pasture on a municipal refuse disposal site. Within 24 hours, 14 ewes were found dead, and the remaining sheep were moved off the site. Both ewes and lambs exhibited disoriented running, followed by apparent blindness, weakness, ataxia, coma, and death. Over the next 4 days, 63 ewes and 80 lambs died with a peak at 3 days after grazing the suspect pasture (157/445, 35% mortality). Two dead 4-month-old lambs and 2 ewes were submitted to the California Animal Health and Food Safety laboratory for necropsy. Grossly, there were bilateral diffuse pulmonary congestion and edema, hydrothorax and hydropericardium with fibrin clots, and multifocally extensive areas of epicardial petechiae, ecchymoses, and pallor. In 1 ewe, there was regional caudodorsal pulmonary hemorrhage and intraluminal tracheal clotted blood. Microscopically in all cases, there was multifocal acute myocardial degeneration and necrosis with nonsuppurative pleocellular myocarditis. Sodium fluoroacetate was detected in kidney from a lamb and a ewe at 27.5 and 12.5 parts per billion, respectively. All sheep were selenium deficient, and concurrent copper deficiency was diagnosed in 3. The pathological and toxicological findings were consistent with 1080 poisoning, possibly exacerbated by micronutrient deficiency. This outbreak raised an alert about the use of restricted products with potential lethal effect in animals in California.eng
dc.formatapplication/pdfeng
dc.language.isoeng
dc.rightsinfo:eu-repo/semantics/restrictedAccesseng
dc.sourceVeterinary pathology 50 (6) : 1022-1027. (Nov. 2013)eng
dc.subjectOvinoses_AR
dc.subjectSheepeng
dc.subjectCompuesto Orgánico del Fluores_AR
dc.subjectOrganofluorine Compoundseng
dc.subjectEnvenenamientoes_AR
dc.subjectPoisoningeng
dc.subject.otherIntoxicaciónes_AR
dc.subject.otherFluoracetato de Sodioes_AR
dc.subject.otherCalifornia, Estados Unidoses_AR
dc.titleAn Outbreak of Sodium Fluoroacetate (1080) Intoxication in Selenium- and Copper-Deficient Sheep in Californiaeng
dc.typeinfo:ar-repo/semantics/artículoes_AR
dc.typeinfo:eu-repo/semantics/articleeng
dc.typeinfo:eu-repo/semantics/publishedVersioneng
dc.description.origenEEA Mercedeses_AR
dc.description.filFil: Giannitti, Federico. University of California. School of Veterinary Medicine. California Animal Health and Food Safety Laboratory System; Estados Unidoses_AR
dc.description.filFil: Anderson, Mark. University of California. School of Veterinary Medicine. California Animal Health and Food Safety Laboratory System; Estados Unidoses_AR
dc.description.filFil: Caspe, Sergio Gaston. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Mercedes; Argentinaes_AR
dc.description.filFil: Mete, A. University of California. School of Veterinary Medicine. California Animal Health and Food Safety Laboratory System; Estados Unidoses_AR
dc.description.filFil: East, N.E. University of California. School of Veterinary Medicine; Estados Unidoses_AR
dc.description.filFil: Mostrom, M. North Dakota State University. Veterinary Diagnostic Laboratory; Estados Unidoses_AR
dc.description.filFil: Poppenga, R. University of California. School of Veterinary Medicine. California Animal Health and Food Safety Laboratory System; Estados Unidoses_AR
dc.subtypecientifico


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