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Distribution and Severity of Placental Lesions Caused by the Chlamydia abortus 1B Vaccine Strain in Vaccinated Ewes
Caspe, Sergio Gaston; Palarea-Albaladejo, Javier; Underwood, Clare; Livingstone, Morag; Wattegedera, Sean Ranjan; Milne, Elspeth; Sargison, Neil Donald; Chianini, Francesca; Longbottom, David (MDPI, 2021-05)Chlamydia abortus infects livestock species worldwide and is the cause of enzootic abortion of ewes (EAE). In Europe, control of the disease is achieved using a live vaccine based on C. abortus 1B strain. Although the ... -
Histopathological analysis of placental lesions caused by Chlamydia abortus 1B vaccine strain in vaccinated ewes
Caspe, Sergio Gaston; Livingstone, Morag; Wattegedera, Sean Ranjan; Aitchison, Kevin; Underwood, Clare; Milne, Elspeth; Sargison, Neil Donald; Chianini, Francesca; Palarea-Albaladejo, Javier; Longbottom, David (Microbiology Society, 2022)Chlamydia abortus is one of the most diagnosed causes of infectious abortion in small ruminants. Infections can be controlled using the live, attenuated C. abortus strain 1B vaccine, which has been associated with infection ... -
The 1B vaccine strain of Chlamydia abortus produces placental pathology indistinguishable from a wild type infection
Caspe, Sergio Gaston; Livingstone, Morag; Frew, David; Aitchison, Kevin; Wattegedera, Sean Ranjan; Entrican, Gary; Palarea-Albaladejo, Javier; McNeilly, Tom Nathan; Milne, Elspeth; Sargison, Neil Donald; Chianini, Francesca; Longbottom, David (Plos One, 2020-11)Chlamydia abortus is one of the most commonly diagnosed causes of infectious abortion in small ruminants worldwide. Control of the disease (Enzootic Abortion of Ewes or EAE) is achieved using the commercial live, attenuated ... -
The extent of placental pathology is negatively correlated to birth weight in ewes infected with the wild-type strain of Chlamydia abortus
Caspe, Sergio Gaston; Palarea-Albaladejo, Javier; Livingstone, Morag; Wattegedera, Sean Ranjan; Milne, Elspeth; Sargison, Neil Donald; Longbottom, David (Elsevier, 2023-06)The placenta is the organ that allows the exchange of oxygen and nutrients between maternal and foetal blood, supplying the requirements of the growing foetus. Consequently, any factor that alters placental integrity may ... -
The Immune Response in the Uteri and Placentae of Chlamydia abortus-Infected Ewes and Its Association with Pregnancy Outcomes
Caspe, Sergio Gaston; Ewing, David Andrew; Livingstone, Morag; Underwood, Clare; Milne, Elspeth; Sargison, Neil Donald; Wattegedera, Sean Ranjan; Longbottom, David (MDPI, 2023-06)The enzootic abortion of ewes, caused by the bacterium Chlamydia abortus (C. abortus), is one of the main causes of abortion in sheep. There are multiple contributory factors, including chlamydial growth, host immune ...