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Benznidazole/Poloxamer 407 Solid Dispersion as a New Strategy to Improve the Treatment of Experimental Trypanosoma cruzi Infection
Devies, Carolina; Simonazzi, Analía; Micheloud, Juan Francisco; Micheloud, Juan Francisco; Ragone, Paula Gabriela; Cid, Alicia Graciela; Sánchez Negrette, Olga; Bermúdez, José María; Parada, Luis Antonio (American Society of Parasitologists, 2020-05-04)Benznidazole and nifurtimox are the only drugs specifically approved for the treatment of Chagas disease. Both compounds are given orally in tablets, but occasionally are ineffective and cause adverse effects. Benznidazole, ...