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Resumen
Congenital toxoplasmosis in humans and in other mammalian species, such as small ruminants, is a well-known cause of abortion and fetal malformations. The calcium-dependent protein kinase 1 (CDPK1) inhibitor BKI-1748 has shown a promising safety profile for its use in humans and a good efficacy against Toxoplasma gondii infection in vitro and in mouse models. Ten doses of BKI-1748 given every other day orally in sheep at 15 mg/kg did not show systemic or
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dc.contributor.author | Sánchez Sánchez, Roberto | |
dc.contributor.author | Imhof, Dennis | |
dc.contributor.author | Hecker, Yanina | |
dc.contributor.author | Ferre, Ignacio | |
dc.contributor.author | Re, Michela | |
dc.contributor.author | Moreno Gonzalo, Javier | |
dc.contributor.author | Blanco Murcia, Javier | |
dc.contributor.author | Mejías López, Elena | |
dc.contributor.author | Hulverson, Matthew | |
dc.contributor.author | Choi, Ryan | |
dc.contributor.author | Ojo, Kayode | |
dc.contributor.author | Barrett, Lynn | |
dc.contributor.author | Hemphill, Andrew | |
dc.contributor.author | Van Voorhis, Wesley | |
dc.contributor.author | Ortega Mora, Luis Miguel | |
dc.date | info:eu-repo/date/embargoEnd/2025-05-17 | |
dc.date.accessioned | 2024-05-17T10:12:54Z | |
dc.date.available | 2024-05-17T10:12:54Z | |
dc.date.issued | 2023-10 | |
dc.identifier.issn | 0022-1899 | |
dc.identifier.other | https://doi.org/10.1093/infdis/jiad470 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12123/17776 | |
dc.identifier.uri | https://academic.oup.com/jid/article-abstract/229/2/558/7331060 | |
dc.description.abstract | Congenital toxoplasmosis in humans and in other mammalian species, such as small ruminants, is a well-known cause of abortion and fetal malformations. The calcium-dependent protein kinase 1 (CDPK1) inhibitor BKI-1748 has shown a promising safety profile for its use in humans and a good efficacy against Toxoplasma gondii infection in vitro and in mouse models. Ten doses of BKI-1748 given every other day orally in sheep at 15 mg/kg did not show systemic or pregnancy-related toxicity. In sheep experimentally infected at 90 days of pregnancy with 1000 TgShSp1 oocysts, the BKI-1748 treatment administered from 48 hours after infection led to complete protection against abortion and congenital infection. In addition, compared to infected/untreated sheep, treated sheep showed a drastically lower rectal temperature increase and none showed IgG seroconversion throughout the study. In conclusion, BKI-1748 treatment in pregnant sheep starting at 48 hours after infection was fully effective against congenital toxoplasmosis. | eng |
dc.format | application/pdf | es_AR |
dc.language.iso | eng | es_AR |
dc.publisher | Oxford University Press | es_AR |
dc.rights | info:eu-repo/semantics/embargoedAccess | es_AR |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | es_AR |
dc.source | The Journal of Infectious Diseases 229 (2) : 558-566 (February 2024) | es_AR |
dc.subject | Oveja | es_AR |
dc.subject | Ewes | eng |
dc.subject | Aborto | es_AR |
dc.subject | Abortion | eng |
dc.subject | Toxoplasma Gondii | eng |
dc.subject | Infección Experimental | es_AR |
dc.subject | Exprimental Infection | eng |
dc.subject | Sanidad Animal | es_AR |
dc.subject | Animal Health | eng |
dc.title | An Early Treatment With BKI-1748 Exhibits Full Protection Against Abortion and Congenital Infection in Sheep Experimentally Infected With Toxoplasma gondii | es_AR |
dc.type | info:ar-repo/semantics/artículo | es_AR |
dc.type | info:eu-repo/semantics/article | es_AR |
dc.type | info:eu-repo/semantics/acceptedVersion | es_AR |
dc.rights.license | Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) | es_AR |
dc.description.origen | EEA Balcarce | es_AR |
dc.description.fil | Fil: Sánchez Sánchez, Roberto. Universidad Complutense de Madrid. Facultad de Veterinaria; España | es_AR |
dc.description.fil | Fil: Imhof, Dennis. University of Berne. Vetsuisse Faculty. Institute of Parasitology; Suiza | es_AR |
dc.description.fil | Fil: Hecker, Yanina Paola. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina | es_AR |
dc.description.fil | Fil: Ferre, Ignacio. Universidad Complutense de Madrid. Facultad de Veterinaria; España | es_AR |
dc.description.fil | Fil: Re, Michela. Universidad Complutense de Madrid. Facultad de Veterinaria; España | es_AR |
dc.description.fil | Fil: Moreno Gonzalo, Javier. Universidad Complutense de Madrid. Facultad de Veterinaria; España | es_AR |
dc.description.fil | Fil: Blanco Murcia, Javier. Universidad Complutense de Madrid. Facultad de Veterinaria; España | es_AR |
dc.description.fil | Fil: Mejías López, Elena. Universidad Complutense de Madrid. Facultad de Veterinaria; España | es_AR |
dc.description.fil | Fil: Hulverson, Matthew. University of Washington. Department of Medicine. Division of Allergy and Infectious Diseases. Center for Emerging and Re-emerging Infectious Diseases; Estados Unidos | es_AR |
dc.description.fil | Fil: Choi, Ryan. University of Washington. Department of Medicine. Division of Allergy and Infectious Diseases. Center for Emerging and Re-emerging Infectious Diseases; Estados Unidos | es_AR |
dc.description.fil | Fil: Arnold, Samuel. University of Washington. Department of Medicine. Division of Allergy and Infectious Diseases. Center for Emerging and Re-emerging Infectious Diseases; Estados Unidos | es_AR |
dc.description.fil | Fil: Ojo, Kayode. University of Washington. Department of Medicine. Division of Allergy and Infectious Diseases. Center for Emerging and Re-emerging Infectious Diseases; Estados Unidos | es_AR |
dc.description.fil | Fil: Barrett, Lynn. University of Washington. Department of Medicine. Division of Allergy and Infectious Diseases. Center for Emerging and Re-emerging Infectious Diseases; Estados Unidos | es_AR |
dc.description.fil | Fil: Hemphill, Andrew. University of Berne. Vetsuisse Faculty. Institute of Parasitology; Suiza | es_AR |
dc.description.fil | Fil: Van Voorhis, Wesley. University of Washington. Department of Medicine. Division of Allergy and Infectious Diseases. Center for Emerging and Re-emerging Infectious Diseases; Estados Unidos | es_AR |
dc.description.fil | Fil: Ortega Mora, Luis Miguel. Universidad Complutense de Madrid. Facultad de Veterinaria; España | es_AR |
dc.subtype | cientifico |
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