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Resumen
Babesia bovis is a tick-transmitted haemoprotozoan and a causative agent of bovine babesiosis, a cattle disease that causes significant economic loss in tropical and subtropical regions. A panel of nineteen micro- and minisatellite markers was used to estimate population genetic parameters of eighteen parasite isolates originating from different continents, countries and geographic regions including North America (Mexico, USA), South America (Argentina, [ver mas...]
dc.contributor.authorFlores, Daniela
dc.contributor.authorMinichiello, Y.
dc.contributor.authorAraujo, Flabio Ribeiro de
dc.contributor.authorShkap, V.
dc.contributor.authorBenitez, Daniel Francisco
dc.contributor.authorEchaide, Ignacio Eduardo
dc.contributor.authorRolls, P.
dc.contributor.authorMosqueda, J.
dc.contributor.authorPacheco, Maria Gabriela
dc.contributor.authorPetterson, Maria Elizabeth
dc.contributor.authorFlorin-Christensen, Mónica
dc.contributor.authorSchnittger, Leonhard
dc.date.accessioned2017-11-13T16:55:40Z
dc.date.available2017-11-13T16:55:40Z
dc.date.issued2013-11
dc.identifier.issn1865-1674 (Print)
dc.identifier.issn1865-1682 (Online)
dc.identifier.otherDOI: 10.1111/tbed.12121
dc.identifier.urihttp://hdl.handle.net/20.500.12123/1756
dc.identifier.urihttp://onlinelibrary.wiley.com/doi/10.1111/tbed.12121/abstract
dc.description.abstractBabesia bovis is a tick-transmitted haemoprotozoan and a causative agent of bovine babesiosis, a cattle disease that causes significant economic loss in tropical and subtropical regions. A panel of nineteen micro- and minisatellite markers was used to estimate population genetic parameters of eighteen parasite isolates originating from different continents, countries and geographic regions including North America (Mexico, USA), South America (Argentina, Brazil), the Middle East (Israel) and Australia. For eleven of the eighteen isolates, a unique haplotype was inferred suggesting selection of a single genotype by either in vitro cultivation or amplification in splenectomized calves. Furthermore, a high genetic diversity (H = 0.780) over all marker loci was estimated. Linkage disequilibrium was observed in the total study group but also in sample subgroups from the Americas, Brazil, and Israel and Australia. In contrast, corresponding to their more confined geographic origin, samples from Israel and Argentina were each found to be in equilibrium suggestive of random mating and frequent genetic exchange. The genetic differentiation (FST) of the total study group over all nineteen loci was estimated by analysis of variance (Θ) and Nei's estimation of heterozygosity (GST') as 0.296 and 0.312, respectively. Thus, about 30% of the genetic diversity of the parasite population is associated with genetic differences between parasite isolates sampled from the different geographic regions. The pairwise similarity of multilocus genotypes (MLGs) was assessed and a neighbour-joining dendrogram generated. MLGs were found to cluster according to the country/continent of origin of isolates, but did not distinguish the attenuated from the pathogenic parasite state. The distant geographic origin of the isolates studied allows an initial glimpse into the large extent of genetic diversity and differentiation of the B. bovis population on a global scale.eng
dc.formatapplication/pdfes_AR
dc.language.isoenges_AR
dc.rightsinfo:eu-repo/semantics/openAccesses_AR
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.sourceTransboundary and Emerging Diseases 60 (s2) : 131–136 (November 2013)
dc.subjectBabesia Bovises_AR
dc.subjectVariación Genéticaes_AR
dc.subjectGenetic Variationeng
dc.subjectBabesiosis
dc.subjectMarcadores Genéticos
dc.subjectGenetic Markerseng
dc.subjectEstructura de la Población
dc.subjectPopulation Structureeng
dc.titleEvidence for extensive genetic diversity and substructuring of the Babesia bovis metapopulationes_AR
dc.typeinfo:ar-repo/semantics/artículoes_AR
dc.typeinfo:eu-repo/semantics/articlees_AR
dc.typeinfo:eu-repo/semantics/publishedVersiones_AR
dc.rights.licenseCreative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.description.filFil: Flores, Daniela. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina
dc.description.filFil: Minichiello, Y. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina
dc.description.filFil: Araujo, Flabio R. EMBRAPA ; Brasil
dc.description.filFil: Shkap, V. Kimron Veterinary Institute; Israel
dc.description.filFil: Benitez, Daniel Francisco. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Mercedes; Argentina
dc.description.filFil: Echaide, Ignacio Eduardo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina
dc.description.filFil: Rolls, P. Tick Fever Centre; Australia
dc.description.filFil: Mosqueda, J. Universidad Autónoma de Querétaro; México
dc.description.filFil: Pacheco, Maria Gabriela. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina
dc.description.filFil: Petterson, Maria Elizabeth. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina
dc.description.filFil: Florin-Christensen, Mónica. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.filFil: Schnittger, Leonhard. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.subtypecientifico


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