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A fungal protease named AsES triggers antiviral immune responses and effectively restricts virus infection in arabidopsis and Nicotiana benthamiana plants
(Oxford University Press, 2022-04)Background and Aims: Plants have evolved complex mechanisms to fight against pathogens. Among these mechanisms, pattern-triggered immunity (PTI) relies on the recognition of conserved microbe- or pathogen-associated molecular ... -
A new cage-like particle adjuvant enhances protection of foot-and-mouth disease vaccine
(Frontiers Media, 2020-07)Foot-and-Mouth Disease (FMD) is an acute viral disease that causes important economy losses. Vaccines with new low-cost adjuvants that stimulate protective immune responses are needed and can be assayed in a mouse model ... -
A new passive immune strategy based on IgY antibodies as a key element to control neonatal calf diarrhea in dairy farms
(BMC, 2020-07)Background: Neonatal diarrhea remains one of the main causes of morbi-mortality in dairy calves under artificial rearing. It is often caused by infectious agents of viral, bacterial, or parasitic origin. Cows vaccination ... -
A novel MHC-II targeted BVDV subunit vaccine induces a neutralizing immunological response in guinea pigs and cattle
(Wiley, 2021-11)Bovine viral diarrhoea virus (BVDV) is a major cause of economic loss in the cattle industry, worldwide. Infection results in reduced productive performance, growth retardation, reduced milk production and increased ... -
A prime-boost combination of a three-protein cocktail and multiepitopic MVA as a vaccine against Babesia bigemina elicits neutralizing antibodies and a Th1 cellular immune response in mice
(Elsevier, 2022-09)In the intraerythrocytic protozoan parasites of the genus Babesia both innate and adaptive immune responses are necessary to confer protection against clinical disease. In particular, the adaptive immune response involves ... -
A transcriptional analysis of cattle immune cells reveals a central role of type 1 interferon in the In vitro innate immune response against Mycobacterium bovis
(MDPI, 2023-09)Bovine tuberculosis is a chronic infectious disease primarily caused by Mycobacterium bovis, a bacterium that affects cattle and other mammals, including humans. Despite the availability of vast research about the immune ... -
Alteraciones neuroinmunes inducidas por exposición a estrés prenatal. Participación de citoquinas y neurotrofinas. Influencia del sexo de la cría
(Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 2015)En el presente trabajo estudiamos el efecto del estrés prenatal (EP) en la respuesta neuroinmune en animales adultos. Observamos que machos y hembras respondieron diferente ante el EP, tanto a nivel inmunológico como ... -
Application of serological tests to assess the efficacy of foot-and-mouth disease vaccination in dairy cattle with or without viral leucosis
(Juniper Publishers, 2018-12)Enzootic bovine leucosis is an infectious viral disease of cattle distributed worldwide that affect dairy cattle over 2 years of age. This disease produces changes in the animal´s immune system that may affect vaccine ... -
Babesia bovis AMA-1, MSA-2c and RAP-1 contain conserved B and T-cell epitopes, which generate neutralizing antibodies and a long-lasting Th1 immune response in vaccinated cattle
(Elsevier, 2022-02)Vaccines against bovine babesiosis must, ideally, induce a humoral immune response characterized by neutralizing antibodies against conserved epitopes and a cellular Th1 immune response. In Babesia bovis, proteins such as ... -
Baculovirus capsid display in vaccination schemes: effect of a previous immunity against the vector on the cytotoxic response to delivered antigens
(Springer, 2018-12)The baculovirus Autographa californica multiple nuclear polyhedrosis virus (AcMNPV) infects lepidopteran invertebrates as natural hosts, although it also has been used as display vector for vaccine development. In this ... -
Bovine colostral cells—the often forgotten component of colostrum
(American Veterinary Medical Association, 2017-05)At birth, neonatal calves have all the essential immune components they need as adult cattle; however, it takes at least 2 to 4 weeks for those components to become fully functional.1,2 The immune system does not become ... -
Bovine macrophages responses to the infection with virulent and attenuated Leptospira interrogans serovar Pomona
(Elsevier, 2019-06)Leptospirosis is a zoonosis, caused by pathogenic spirochetes of the genus Leptospira. Although cattle are usually the maintenance hosts of serovar Hardjo, Pomona is the most frequent serovar circulating in Argentina. The ... -
Candidate Gene Approach for Parasite Resistance in Sheep – Variation in Immune Pathway Genes and Association with Fecal Egg Count
(Plos One, 2014-02-12)Sheep chromosome 3 (Oar3) has the largest number of QTLs reported to be significantly associated with resistance to gastro-intestinal nematodes. This study aimed to identify single nucleotide polymorphisms (SNPs) within ... -
Caracterización del virus de influenza en cerdos en Argentina
(Facultad de Ciencias Veterinarias, Universidad de Buenos Aires, 2016)La infección por Influenza A virus (IAV) es considerada una de las principales causas de enfermedad respiratoria en cerdos. Además, su carácter zoonótico representa un riesgo para la salud pública. En Argentina, si bien ... -
Cápsides virales como vacunas contra el virus de la Fiebre Aftosa. Selección, potenciación y estudio de la respuesta inmune inducida
(Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 2022-06-08)La Fiebre Aftosa (FA) es una enfermedad infectocontagiosa aguda, causada por el Virus de la Fiebre Aftosa (VFA). La enfermedad afecta a bovinos, ovinos, cerdos y varias especies silvestres, se caracteriza por la aparición ... -
Cyclophosphamide enhances the release of tumor exosomes that elicit a specific immune response in vivo in a murine T-cell lymphoma
(Elsevier, 2019-03)Exosomes are 60–150 nm small extracellular vesicles (EVs) released by most cells. Tumor-cell-derived exosomes, used as a vaccine, elicit a specific cytotoxic response against tumor cells, usually with a greater immunogenicity ... -
Cytokine expression profile of B. melitensis-infected goat monocyte-derived macrophages
(Elsevier, 2023-05)Brucella parasitize the macrophage where is able to replicate and modulate the immune response in order to establish a chronic infection. The most adequate response to control and eliminate Brucella infection is a type 1 ... -
Desarrollo y evaluación de un candidato vacunal para IBD producido en plantas: una alternativa a las vacunas tradicionales
(Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 2018)El Virus de la enfermedad infecciosa de la bursa (IBDV) es el agente etiológico responsable de una enfermedad aguda contagiosa e inmunosupresora que afecta pollos jóvenes y causa importantes pérdidas económicas. La vacunación ... -
Developments in plant-based vaccines against diseases of concern in developing countries
(BENTHAM Open, 2010)Vaccination has been extensively used to prevent, eradicate and control infectious diseases. However, the development and implementation of new vaccines remains prohibitively expensive for middle and low income countries where ... -
Early Adaptive Immune Responses in the Respiratory Tract of Foot-and-Mouth Disease Virus-Infected Cattle
(2013-03)Foot-and-mouth disease (FMD) is a highly contagious viral disease which affects both domestic and wild biungulate species. This acute disease, caused by the FMD virus (FMDV), usually includes an active replication phase ...