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A beginner’s guide for FMDV quasispecies analysis: sub-consensus variant detection and haplotype reconstruction using next-generation sequencing
(Oxford Academic Press, 2020-09)Deep sequencing of viral genomes is a powerful tool to study RNA virus complexity. However, the analysis of next-generation sequencing data might be challenging for researchers who have never approached the study of viral ... -
A computational study of the interaction of the foot and mouth disease virus VP1 with monoclonal antibodies
(Elsevier, 2015-10)Foot and mouth disease is caused by a non-enveloped virus (FMDV), which disposes several antigenic sites at the surface of their capsid proteins. The most relevant and immunodominant antigenic site of FMDV (site A or AnSA) ... -
A new cage-like particle adjuvant enhances protection of foot-and-mouth disease vaccine
(Frontiers Media, 2020-07)Foot-and-Mouth Disease (FMD) is an acute viral disease that causes important economy losses. Vaccines with new low-cost adjuvants that stimulate protective immune responses are needed and can be assayed in a mouse model ... -
Accuracy of traditional and novel serology tests for predicting cross-protection in foot-and-mouth disease vaccinated cattle
(Elsevier, 2014-01-16)Foot-and-mouth disease virus (FMDV) antigenic-match between vaccine and field viruses has traditionally been estimated in vitro by computing the r1 value using virus neutralization test (VNT) or ELISA titers. In this study ... -
Application of serological tests to assess the efficacy of foot-and-mouth disease vaccination in dairy cattle with or without viral leucosis
(Juniper Publishers, 2018-12)Enzootic bovine leucosis is an infectious viral disease of cattle distributed worldwide that affect dairy cattle over 2 years of age. This disease produces changes in the animal´s immune system that may affect vaccine ... -
Baculovirus AcMNPV induces type I interferons and NK/NKT cells-mediated protection against foot-and-mouth disease virus in mice
(Elsevier, 2020-08)Foot-and-mouth disease is a viral illness that affects cloven-hoofed animals causing serious economic losses. Inactivated vaccines against its causative agent, foot-and-mouth disease virus (FMDV), require approximately ... -
Bovine dendritic cell activation, T cell proliferation and antibody responses to foot-and-mouth disease, is similar with inactivated virus and virus like particles
(Frontiers Media, 2020-09)Foot-and-mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals that causes severe economic losses in the livestock industry. Currently available vaccines are based on the inactivated FMD virus (FMDV). ... -
Cápsides virales como vacunas contra el virus de la Fiebre Aftosa. Selección, potenciación y estudio de la respuesta inmune inducida
(Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 2022-06-08)La Fiebre Aftosa (FA) es una enfermedad infectocontagiosa aguda, causada por el Virus de la Fiebre Aftosa (VFA). La enfermedad afecta a bovinos, ovinos, cerdos y varias especies silvestres, se caracteriza por la aparición ... -
Comparison of strategies for the production of FMDV empty capsids using the Baculovirus Vector System
(Springer, 2014-11)Recombinant FMDV empty capsids have been produced in insect cells and larvae using the baculovirus expression system, although protein yield and efficiency of capsid assembly have been highly variable. In this work, two ... -
Comparison of transient and stable expression of foot-and-mouth disease virus capsid proteins in mammalian cells
(Scientific Research, 2013-12)Foot-and-mouth disease is a highly contagious disease that produces severe economic losses in the livestock industry. This disease is being controlled by the use of an inactivated vaccine. However, the use of recombinant ... -
Dendrimeric peptides can confer protection against foot-and-mouth disease virus in cattle
(2017-09)Foot-and-mouth disease virus (FMDV) causes a highly contagious disease in cloven-hoofed animals. A synthetic vaccine candidate consisting of dendrimeric peptides harbouring two copies of a B-epitope [VP1(136–154)] linked ... -
Differences in the virulence of two strains of Foot-and-Mouth Disease Virus Serotype A with the same spatiotemporal distribution
(Elsevier, 2010-01)During the 2000–2001 epidemic of Foot-and-Mouth Disease Virus (FMDV) in Argentina, two FMDV serotype A viruses were identified among others. Since different pathogenic properties between these virus strains were noticed ... -
Differential replication of Foot-and-mouth disease viruses in mice determine lethality
(2017-09)Adult C57BL/6J mice have been used to study Foot-and-mouth disease virus (FMDV) biology. In this work, two variants of an FMDV A/Arg/01 strain exhibiting differential pathogenicity in adult mice were identified and ... -
Early Adaptive Immune Responses in the Respiratory Tract of Foot-and-Mouth Disease Virus-Infected Cattle
(2013-03)Foot-and-mouth disease (FMD) is a highly contagious viral disease which affects both domestic and wild biungulate species. This acute disease, caused by the FMD virus (FMDV), usually includes an active replication phase ... -
Early protection against foot-and-mouth disease virus in cattle using an inactivated vaccine formulated with Montanide ESSAI IMS D 12802 VG PR adjuvant
(Elsevier, 2014-04-17)Foot and mouth disease is an acute disease of cattle with a broad distribution around the world. Due to the fast spread of FMDV infections, control measures must be applied immediately after an outbreak, such as the use ... -
Editorial : Foot-and-mouth disease epidemiology, vaccines and vaccination : moving forward
(Frontiers Media, 2023-06)Vaccination has played a major role in foot-and-mouth disease (FMD) control. There are different approaches to the design and implementation of vaccination campaigns, and epidemiological information is paramount in influencing ... -
Estimating the protection afforded by foot-and-mouth disease vaccines in the laboratory
(Elsevier, 2019-09)Foot-and-mouth disease (FMD) vaccines must be carefully selected and their application closely monitored to optimise their effectiveness. This review covers serological techniques for FMD vaccine quality control, including ... -
Evaluation of immune responses of stabilised SAT2 antigens of foot-and-mouth disease in cattle
(2017)Foot-and-mouth disease (FMD) vaccines with improved stability and less reliant on a cold-chain are needed to improve the longevity of immune responses elicited in animals. This is especially so for serotypes O and SAT2 ... -
Evaluation of serological response to foot-and-mouth disease vaccination in BLV infected cows
(2016)Bovine Leukemia Virus (BLV) produces disorders on the immune system in naturally infected animals, which may counteract the development of immunity after vaccination. The aim of this study was to investigate whether healthy ... -
Expresión de antígenos derivados del virus de la fiebre aftosa en diferentes sistemas eucarióticos
(Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 2000)La fiebre aftosa es una enfermedad de gran importancia económica que afecta principalmente al ganado bovino. Esta enfermedad está causada por un picornavirus, el virus de la fiebre aftosa (VFA). El control de la enfermedad ...