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A β-Hairpin Motif in the Envelope Protein E2 Mediates Receptor Binding of Bovine Viral Diarrhea Virus
Merwaiss, Fernando; Pascual, María José; Pomilio, María Trinidad; Lopez, Maria Gabriela; Taboga, Oscar Alberto; Alvarez, Diego Ezequiel (MDPI, 2021-06)Pestivirus envelope protein E2 is crucial to virus infection and accomplishes virus-receptor interaction during entry. However, mapping of E2 residues mediating these interactions has remained unexplored. In this study, ... -
Structure-based drug design for envelope protein E2 uncovers a new class of bovine viral diarrhea inhibitors that block virus entry
Pascual, María José; Merwaiss, Fernando; Leal, Emilse Soledad; Quintana, Maria Eugenia; Capozzo, Alejandra Victoria; Cavasotto, Claudio Norberto; Bollini, Mariela; Alvarez, Diego Ezequiel (Elsevier, 2018-01)Antiviral targeting of virus envelope proteins is an effective strategy for therapeutic intervention of viral infections. Here, we took a computer-guided approach with the aim of identifying new antivirals against the ...