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    • Clostridium perfringens epsilon toxin induces permanent neuronal degeneration and behavioral changes 

      Morris, Winston Eduardo; Goldstein, Jorge; Redondo, Leandro Martí­n; Cangelosi, Adriana; Geoghegan, Patricia; Brocco, Marcela Adriana; Loidl, Fabián C.; Fernandez Miyakawa, Mariano Enrique (2017-05)
      Clostridium perfringens epsilon toxin (ETX), the most potent toxin produced by this bacteria, plays a key role in the pathogenesis of enterotoxaemia in ruminants, causing brain edema and encephalomalacia. Studies of animals ...

    • IgY-based antivenom against Bothrops alternatus: Production and neutralization efficacy 

      Leiva, Carlos Leónidas; Cangelosi, Adriana; Mariconda, Virginia; Farace, Mariano; Geoghegan, Patricia; Brero, Luisa; Fernandez Miyakawa, Mariano Enrique; Chacana, Pablo Anibal (Elsevier, 2019-05)
      Antivenom for the treatment of bothropic snakebite is a priority for public health institutions from Latin America. An alternative to the conventional antivenom production is based on the use of egg yolk antibodies – ...

    • In vivo neutralization of bee venom lethality by IgY antibodies 

      Leiva, Carlos Leónidas; Geoghegan, Patricia; Lammer, Mónica; Cangelosi, Adriana; Mariconda, Virginia; Celi Castillo, Ana Beatriz; Brero, Luisa; Chacana, Pablo (Elsevier, 2021-07)
      Bee venom is a complex mixture of molecules, among which melittin and phospholipase A2 (PLA2) are the toxic components involved in envenoming accidents with multiple honeybee stings. Traditionally, the treatment of envenomings ...

    • Use of adjuvant ISA VG 71 to produce neutralizing egg yolk antibodies against bothropic venom 

      Leiva, Carlos Leónidas; Cangelosi, Adriana; Mariconda, Virginia; Celi Castillo, Ana Beatriz; Joaquim, Patricia Estefania; Geoghegan, Patricia; Fernandez Miyakawa, Mariano Enrique; Chacana, Pablo (Springer, 2023-02)
      The use of egg yolk antibodies—IgY technology—represents an alternative to the production of mammalian immunoglobulins and has several advantages regarding animal welfare and lower costs of production. The use of adjuvants ...