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Replication and transmission features of two experimental vaccine candidates against bovine tuberculosis subcutaneously administrated in a murine model
(Elsevier, 2022-05)Cattle vaccination is an attractive approach in compliance with control and eradication programs against Bovine Tuberculosis (bTB). Today, there is no anti bTB vaccine licensed. Two vaccine candidates, MbΔmce2 and MbΔmce2-phoP ... -
Role of PhoPR in the response to stress of Mycobacterium bovis
(Elsevier, 2021-02)PhoP is part of the two-component PhoPR system that regulates the expression of virulence genes of Mycobacteria. The goal of this work was to elucidate the role of PhoP in the mechanism that Mycobacterium bovis, the causative ... -
Rv2577 of Mycobacterium tuberculosis is a virulence factor with dual phosphatase and phosphodiesterase functions
(Frontiers Media, 2020-10)Tuberculosis, a lung disease caused by Mycobacterium tuberculosis (Mtb), is one of the ten leading causes of death worldwide affecting mainly developing countries. Mtb can persist and survive inside infected cells through ... -
Spatial distribution of Mycobacterium bovis spoligotypes in cattle from the state of Minas Gerais, Brazil
(Springer, 2022-07)Genotyping methods have led to a better understanding of the epidemiology of Mycobacterium bovis (M. bovis) infection, and its transmission dynamics, as well as the possible phylogenetic relationships between Mycobacterium ... -
Study of the in vivo role of Mce2R, the transcriptional regulator of mce2 operon in Mycobacterium tuberculosis
(BMC, 2013-09)Background: Tuberculosis is one of the leading causes of mortality throughout the world. Mycobacterium tuberculosis, the agent of human tuberculosis, has developed strategies involving proteins and other compounds called ... -
Surveillance and characterization of drug‑resistant mycobacterium tuberculosis isolated in a reference hospital from Argentina during 8 years’ period
(Wolters Kluwer, 2019-09)Background: Argentina is considered a country with a middle tuberculosis (TB) incidence. However, according to the last national epidemiological report released in 2018, since 2013, the trends are steadily increasing. The ... -
Tuberculosis bovina : descripción de la respuesta inmune humoral en animales naturalmente infectados
(Universidad de Buenos Aires, 2022-06)La respuesta inmune a la infección por Mycobacterium bovis es predominantemente mediada por células. A partir de ello se diseñaron diversas metodologías diagnósticas como la intradermorreacción (IDR). Los ensayos serológicos, ... -
Tuberculosis bovina : transmisibilidad de cepas de Mycobacterium bovis y detección de micobacterias en menudencias comercializadas en bocas de expendio de carne
(Facultad de Ciencias Veterinarias, Universidad de Buenos Aires, 2019)La tuberculosis bovina, causada por Mycobacterium bovis (M. bovis), es endémica en la Argentina. Su presencia en el ganado bovino representa un riesgo para la salud humana debido a su carácter zoonótico, pudiendo además ... -
Tuberculosis in swine co-infected with Mycobacterium avium subsp. hominissuis and Mycobacterium bovis in a cluster from Argentina
(Cambridge University Press, 2015-04)In Argentina little is known about the epidemiology of tuberculosis (TB) infection in swine. We characterized the epidemiological dynamics of Mycobacterium avium complex (MAC) infection in a swine population of Argentina ... -
Tuberculosis vaccine candidates based on mycobacterial cell envelope components
(Elsevier, 2019-03)Even after decades searching for a new and more effective vaccine against tuberculosis, the scientific community is still pursuing this goal due to the complexity of its causative agent, Mycobacterium tuberculosis (Mtb). ... -
Understanding the relationship between Mycobacterium bovis spoligotypes from cattle in Latin American Countries
(Elsevier, 2013-02)Spoligotyping is the most frequently used method for genotyping isolates of Mycobacterium bovis worldwide. In the current work, we compared spoligotypes from 1684 M. bovis isolates from Argentina (816), Brazil (412), Chile ... -
Vigilancia epidemiológica de tuberculosis : ¿Puede el engorde a corral brindar información adicional?
(Asociación Argentina de Veterinarios de Laboratorios de Diagnóstico, 2021)La tuberculosis bovina (TB) es una infección endémica en rodeos bovinos de Argentina. El movimiento de bovinos es un factor de riesgo para el ingreso de TB en rodeos de engorde (Milne et al., 2019). Sin embargo, esta es ...