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Deletion of A44L, A46R and C12L vaccinia virus genes from the MVA genome improved the vector immunogenicity by modifying the innate immune response generating enhanced and optimized specific T-Cell responses
(2016-05)MVA is an attenuated vector that still retains immunomodulatory genes. We have previously reported its optimization after deleting the C12L gene, coding for the IL-18 binding-protein. Here, we analyzed the immunogenicity ... -
Development of a construct-based risk assessment framework for genetic engineered crops
(2016)Experience gained in the risk assessment (RA) of genetically engineered (GE) crops since their first experimental introductions in the early nineties, has increased the level of familiarity with these breeding methodologies ... -
Differential mRNA accumulation upon early arabidopsis thaliana infection with ORMV and TMV-Cg Is associated with distinct endogenous small RNAs Level
(2015-08-03)Small RNAs (sRNAs) play important roles in plant development and host-pathogen interactions. Several studies have highlighted the relationship between viral infections, endogenous sRNA accumulation and transcriptional ... -
Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cells
(Wiley, 2022-11)The ErbB2 receptor tyrosine kinase plays a key role in mammary gland development. It forms large clusters which serve as signaling platforms for integration of extracellular information. The discoidin domain receptor (DDR) ... -
Dissecting maize diversity in lowland South America : genetic structure and geographic distribution models
(2016)Background: Maize landraces from South America have traditionally been assigned to two main categories: Andean and Tropical Lowland germplasm. However, the genetic structure and affiliations of the lowland gene pools have ... -
Diversity and distribution of lepidoptera-specific toxin genes in Bacillus thuringiensis strains from Argentina
(2017-05)A total of 268 Bacillus thuringiensis strains obtained from different sources of Argentina were analyzed to determine the diversity and distribution of the cry1, cry2, cry8, cry9 and vip3A genes encoding for lepidopteran-specific ... -
Draft Genome Sequence of Bacillus thuringiensis INTA Fr7-4
(2017)We report here the complete annotated 6,035,547-bp draft genome sequence of Bacillus thuringiensis INTA Fr7-4. This strain contains three cry8 and two vip1 and vip2 insecticidal toxin genes. -
Draft genome sequences of two mycobacterium bovis strains isolated from beef cattle in Paraguay
(2017-07)This work reports the draft genome sequences of the Mycobacterium bovis strains M1009 and M1010, isolated from the lymph nodes of two infected cows on a beef farm in Paraguay. Comparative genomics between these strains and ... -
Early genetic consequences of defaunation in a large-seeded vertebrate-dispersed palm (Syagrus romanzoffiana)
(2017)Plant populations are seriously threatened by anthropogenic habitat disturbance. In particular, defaunation may disrupt plantdisperser mutualisms, thus reducing levels of seed-mediated gene flow and genetic variation in ... -
Effects of deletion of the ac109 gene of Autographa californica nucleopolyhedrovirus on interactions with mammalian cells
(2017-03)Baculoviruses are able to enter into mammalian cells, where they can express a transgene that is placed under an appropriate promoter, without producing infectious progeny. ORF109 encodes an essential baculovirus protein ... -
Efficient edition of the bovine PRNP prion gene in somatic cells and IVF embryos using the CRISPR/Cas9 system
(2016-11)The recently developed engineered nucleases, such as zinc-finger nucleases, transcription activator-like effector nucleases, and clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated nuclease ... -
Efficient method for targeted gene disruption by homologous recombination in Mycobacterium avium subspecie paratuberculosis
(Elsevier, 2020-09)Targeted gene disruption by homologous recombination, has been widely used in mycobacterium species to understand the genetic basis of virulence and persistence in the host and to develop efficacious potential live vaccines. ... -
Estructura genética de poblaciones de Phytophthora capsici en el noreste de la provincia de Buenos Aires, Argentina
(Gerencia de Comunicación e Imagen Institucional, DNA SICC, INTA, 2016-04)Phytophthora capsici causa enfermedades destructivas en todo el mundo. El patógeno es heterotálico y los dos tipos de apareamiento (TAs) son requeridos para la reproducción sexual. La razón de TAs varía entre regiones ... -
Estudio de los cambios transcriptómicos producidos por infecciones virales en plantas, rol de fitohormonas y su vinculación con la progresión de síntomas
(Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 2014-08)Las pérdidas en cultivos ocasionadas por virus dependen mayormente de la severidad de los síntomas producidos. La comprensión de los mecanismos moleculares que subyacen a la producción de síntomas es de importancia para ... -
Estudios genómicos y funcionales en Anaplasma marginale y en bacterias intracelulares de la clase alfa-proteobacteria y su relación con la reducción del genoma
(Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 2013)La subdivisión α- de la clase proteobacteria representa un grupo sumamente diverso y heterogéneo de bacterias con una gran variabilidad en sus características genómicas, biológicas y ecológicas. Dentro de esta subdivisión ... -
Evolution of pre‐zygotic and post‐zygotic barriers to gene flow among three cryptic species within the Anastrepha fraterculus complex
(Wiley, 2013-09)Tropical tephritids are ideally suited for studies on population divergence and speciation because they include species groups undergoing rapid radiation, in which morphologically cryptic species and sister species are ... -
Expression analysis of genes putatively associated with hygienic behavior in selected stocks of Apis mellifera L. from Argentina
(2017-11)Hygienic behavior is an economically beneficial, heritable trait, which has evolved to limit the impact of honeybee pathogens. Selecting and breeding colonies with high levels of hygienic behavior has become a feasible and ... -
First complete genome sequence of potato leafroll virus from Argentina
(2017-07)In this study, we determined for the first time the complete genomic sequence of an Argentinian isolate of Potato leafroll virus (PLRV), the type species of the genus Polerovirus. The isolate sequenced came from a Solanum ... -
First Genome Sequence of Leptospira interrogans Serovar Pomona, Isolated from a Bovine Abortion
(2016)Leptospirosis is a widespread zoonosis and a re-emergent disease of global distribution with major relevance in veterinary pro- duction. Here, we report the whole-genome sequence of Leptospira interrogans serovar Pomona ... -
First report of isolation and molecular characterization of bubaline herpesvirus 1 (BuHV1) from Argentinean water buffaloes
(2014-11)Herpesviruses have mainly co-evolved with their hosts for millions of years. However, bovine herpesvirus 1 (BoHV1) and related ruminant alphaherpesviruses have been reported to cross the species barrier. Bubaline herpesvirus ...