resumen
Abstract
The enzootic abortion of ewes, caused by the bacterium Chlamydia abortus (C. abortus), is one of the main causes of abortion in sheep. There are multiple contributory factors, including chlamydial growth, host immune response, and hormonal balance, that result in different pregnancy outcomes, such as abortion, the birth of weak lambs that may die, or healthy lambs. This study aimed to determine the relationship between phenotypical patterns of immune cell
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dc.contributor.author | Caspe, Sergio Gaston | |
dc.contributor.author | Ewing, David Andrew | |
dc.contributor.author | Livingstone, Morag | |
dc.contributor.author | Underwood, Clare | |
dc.contributor.author | Milne, Elspeth | |
dc.contributor.author | Sargison, Neil Donald | |
dc.contributor.author | Wattegedera, Sean Ranjan | |
dc.contributor.author | Longbottom, David | |
dc.date.accessioned | 2023-07-03T11:24:52Z | |
dc.date.available | 2023-07-03T11:24:52Z | |
dc.date.issued | 2023-06 | |
dc.identifier.issn | 2076-0817 | |
dc.identifier.other | https://doi.org/10.3390/pathogens12060846 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12123/14680 | |
dc.identifier.uri | https://www.mdpi.com/2076-0817/12/6/846 | |
dc.description.abstract | The enzootic abortion of ewes, caused by the bacterium Chlamydia abortus (C. abortus), is one of the main causes of abortion in sheep. There are multiple contributory factors, including chlamydial growth, host immune response, and hormonal balance, that result in different pregnancy outcomes, such as abortion, the birth of weak lambs that may die, or healthy lambs. This study aimed to determine the relationship between phenotypical patterns of immune cell infiltration and different pregnancy outcomes in twin-bearing sheep (both lambs born dead; one alive and one dead; both alive) when experimentally infected with C. abortus. Both the sheep uteri and placentae were collected after parturition. All samples were analysed for specific immune cell features, including cell surface antigens and the T-regulatory (Treg) cell-associated transcription factor and cytokines, by immunohistochemistry and in situ hybridisation. Some of these immunological antigens were evaluated in ovine reproductive tissues for the first time. Differential patterns of T helper/Treg cells revealed significant group effects in the placentae. It suggests the potential role that the balance of lymphocyte subsets may play in affecting different pregnancy outcomes in C. abortus-infected sheep. The present study provides novel detailed information about the immune responses observed at the maternofoetal interface in sheep at the time of pre-term abortion or lambing. | eng |
dc.format | application/pdf | es_AR |
dc.language.iso | eng | es_AR |
dc.publisher | MDPI | es_AR |
dc.rights | info:eu-repo/semantics/openAccess | es_AR |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | es_AR |
dc.source | Pathogens 12 (6) : 846. (June 2023) | es_AR |
dc.subject | Oveja | es_AR |
dc.subject | Ewes | eng |
dc.subject | Chlamydophila abortus | eng |
dc.subject | Enfermedades de los Animales | es_AR |
dc.subject | Animal Diseases | eng |
dc.subject | Aborto | es_AR |
dc.subject | Abortion | eng |
dc.subject | Placenta | eng |
dc.subject | Respuesta Inmunológica | es_AR |
dc.subject | Immune Response | eng |
dc.subject.other | Chlamydia abortus | es_AR |
dc.title | The Immune Response in the Uteri and Placentae of Chlamydia abortus-Infected Ewes and Its Association with Pregnancy Outcomes | es_AR |
dc.type | info:ar-repo/semantics/artículo | es_AR |
dc.type | info:eu-repo/semantics/article | es_AR |
dc.type | info:eu-repo/semantics/publishedVersion | es_AR |
dc.rights.license | Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) | es_AR |
dc.description.origen | EEA Mercedes | es_AR |
dc.description.fil | Fil: Caspe, Sergio Gaston. Moredun Research Institute; Reino Unido | es_AR |
dc.description.fil | Fil: Caspe, Sergio Gaston. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Mercedes; Argentina | es_AR |
dc.description.fil | Fil: Ewing, David Andrew. Biomathematics & Statistics Scotland; Reino Unido | es_AR |
dc.description.fil | Fil: Livingstone, Morag. Moredun Research Institute; Reino Unido | es_AR |
dc.description.fil | Fil: Underwood, Clare. Moredun Research Institute; Reino Unido | es_AR |
dc.description.fil | Fil: Milne, Elspeth. University of Edinburgh. Royal (Dick) School of Veterinary Studies; Reino Unido | es_AR |
dc.description.fil | Fil: Sargison, Neil Donald. University of Edinburgh. Royal (Dick) School of Veterinary Studies; Reino Unido | es_AR |
dc.description.fil | Fil: Wattegedera, Sean Ranjan. Moredun Research Institute; Reino Unido | es_AR |
dc.description.fil | Fil: Longbottom, David. Moredun Research Institute; Reino Unido | es_AR |
dc.subtype | cientifico |
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