• Mycobacterium bovis infection in a horse with granulomatous enterocolitis 

      Sarradell, Javier E.; Alvarez, Julio; Biscia, Mariana; Zumarraga, Martin Jose; Wunschmann, Arno; Armien, Aníbal G.; Perez, Andrés M. (Sage Publications, 2015-03)
      A 2-year-old dappled Percheron horse had a wasting condition that did not respond to antibiotic treatments and ultimately resulted in death. Thickening of the wall of the large colon and enlargement of the mesenteric lymph ...
    • Pathogenesis of domestic pigs submitted to mycobacterial sensitizations previous to experimental infection with Mycobacterium bovis 

      Cuerda, Maria Ximena; Colombatti Olivieri, Maria Alejandra; Gravisaco, María José; Marfil, Maria Jimena; Barandiaran, Soledad; Sevilla, Iker A.; Garrido, Joseba M.; Moyano, Roberto Damian; Zumarraga, Martin Jose; Romano, Maria Isabel; Juste, Ramón A.; Santangelo, María De La Paz (INIA (España), 2022-03)
      Aim of study: To demonstrate the virulence of a Mycobacterium bovis local pig isolate in order to contribute to a better understanding of the pathological and immunological consequences of M. bovis infection in previous ...
    • Patterns and processes of mycobacterium bovis evolution revealed by phylogenomic analyses 

      Patané, José S.L.; Martins Jr, Joaquim; Castelão, Ana Beatriz C.; Nishibe, Christiane; Montera, Luciana; Bigi, Fabiana; Zumarraga, Martin Jose; Cataldi, Angel Adrian; Fonseca Junior, Antônio; Roxo, Eliana; Osório, Ana Luiza Alves Rosa; Jorge, Klaudia dos Santos Goncalves; Thacker, Tyler C.; Almeida, Nalvo Franco; Araujo, Flabio Ribeiro de; Setubal, Joâo C. (Oxford University Press, 2017-03)
      Mycobacterium bovis is an important animal pathogen worldwide that parasitizes wild and domesticated vertebrate livestock as well as humans. A comparison of the five M. bovis complete genomes from the United Kingdom, South ...
    • Recent advances in non-specific immune memory against bovine tuberculosis 

      Blanco, Federico Carlos; Sabio Y Garcia, Julia Veronica; Bigi, Fabiana (Elsevier, 2021-04)
      Bovine tuberculosis is an important worldwide disease mainly related to cattle, although it also affects other mammals, including humans. In recent years, there have been considerable advances in the knowledge of the immune ...
    • Replication and transmission features of two experimental vaccine candidates against bovine tuberculosis subcutaneously administrated in a murine model 

      Ferrara Muñiz, Ximena; Garcia, Elizabeth Andrea; Blanco, Federico Carlos; Bigi, Fabiana; Zumarraga, Martin Jose; Cataldi, Angel Adrian; Eirin, Maria Emilia (Elsevier, 2022-05)
      Cattle vaccination is an attractive approach in compliance with control and eradication programs against Bovine Tuberculosis (bTB). Today, there is no anti bTB vaccine licensed. Two vaccine candidates, MbΔmce2 and MbΔmce2-phoP ...
    • Role of PhoPR in the response to stress of Mycobacterium bovis 

      Garcia, Elizabeth Andrea; Blanco, Federico Carlos; Klepp, Laura Ines; Pazos, Adriana Alejandra; McNeil, Michael; Jackson, Mary; Bigi, Fabiana (Elsevier, 2021-02)
      PhoP is part of the two-component PhoPR system that regulates the expression of virulence genes of Mycobacteria. The goal of this work was to elucidate the role of PhoP in the mechanism that Mycobacterium bovis, the causative ...
    • Spatial distribution of Mycobacterium bovis spoligotypes in cattle from the state of Minas Gerais, Brazil 

      Souza, Mariana Assunção de; Lopes, Thaís Aline Carolino; Silva, Brendhal Almeida; Bombonato, Nadia Grandi; Dib, Cristina Corsi; Marfil, Maria Jimena; Zumarraga, Martin Jose; Lima, Anna Monteiro Correia (Springer, 2022-07)
      Genotyping methods have led to a better understanding of the epidemiology of Mycobacterium bovis (M. bovis) infection, and its transmission dynamics, as well as the possible phylogenetic relationships between Mycobacterium ...
    • The subunit vaccine H65 + CAF01 increased the BCG- protection against Mycobacterium bovis infection in a mouse model of bovine tuberculosis 

      Blanco, Federico Carlos; Garcia, Elizabeth Andrea; Aagaard, Claus; Bigi, Fabiana (Elsevier, 2021-05)
      H65, a fusion protein of three pairs of ESX-secreted antigens of Mycobacterium tuberculosis and Mycobacterium bovis, formulated with the liposomal adjuvant CAF01 has been shown to confer protection against M. tuberculosis ...
    • Tuberculosis bovina : descripción de la respuesta inmune humoral en animales naturalmente infectados 

      Sammarruco, Romina Ayelén; Ruiz Menna, Victoria Aymara; Delgado, Fernando Oscar; Garro, Carlos Javier; Garbaccio, Sergio Gabriel (Universidad de Buenos Aires, 2022-06)
      La respuesta inmune a la infección por Mycobacterium bovis es predominantemente mediada por células. A partir de ello se diseñaron diversas metodologías diagnósticas como la intradermorreacción (IDR). Los ensayos serológicos, ...
    • Tuberculosis bovina : transmisibilidad de cepas de Mycobacterium bovis y detección de micobacterias en menudencias comercializadas en bocas de expendio de carne 

      Marfil, Maria Jimena (Facultad de Ciencias Veterinarias, Universidad de Buenos Aires, 2019)
      La tuberculosis bovina, causada por Mycobacterium bovis (M. bovis), es endémica en la Argentina. Su presencia en el ganado bovino representa un riesgo para la salud humana debido a su carácter zoonótico, pudiendo además ...
    • Tuberculosis in swine co-infected with Mycobacterium avium subsp. hominissuis and Mycobacterium bovis in a cluster from Argentina 

      Barandiaran, Soledad; Pérez, Andrés M.; Gioffre, Andrea; Martinez Vivot, Marcela; Cataldi, Angel Adrian; Zumarraga, Martin Jose (Cambridge University Press, 2015-04)
      In Argentina little is known about the epidemiology of tuberculosis (TB) infection in swine. We characterized the epidemiological dynamics of Mycobacterium avium complex (MAC) infection in a swine population of Argentina ...
    • Understanding the relationship between Mycobacterium bovis spoligotypes from cattle in Latin American Countries 

      Zumarraga, Martin Jose; Arriaga, Camila; Barandiaran, Soledad; Cobos-Marín, Laura; de Waard, Jacobus; Estrada-Garcia, Iris; Figueiredo, Telma; Figueroa, Alvaro; Gimenez, Francisco; Gomes, Harrison M.; Gonzalez-y-Merchand, Jorge A.; Macías, Analía; Milián-Suazo, Feliciano; Rodríguez, Cesar Alejandro Rosales; Santillán, Marco Antonio; Suffys, Philip Noel; Trangoni, Marcos David; Zarraga, Ana Maria; Cataldi, Angel Adrian (Elsevier, 2013-02)
      Spoligotyping is the most frequently used method for genotyping isolates of Mycobacterium bovis worldwide. In the current work, we compared spoligotypes from 1684 M. bovis isolates from Argentina (816), Brazil (412), Chile ...
    • Use of touch-down polymerase chain reaction to enhance the sensitivity of Mycobacterium bovis detection 

      Zumarraga, Martin Jose; Meikle, Virginia; Bernardelli, Amelia; Abdala, Alejandro Ariel; Tarabla, Hector Dante; Romano, Maria Isabel; Cataldi, Angel Adrian (Sage Publications, 2005-05)
      The confirmatory diagnosis of Mycobacterium bovis (M. bovis) in animal samples is carried out by culture in Stonebrink media. However, culture is very slow because of the extremely long duplication time of the bacillus and ...