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In Silico Survey and Characterization of Babesia microti Functional and Non-Functional Proteases

Abstract
Human babesiosis caused by the intraerythrocytic apicomplexan Babesia microti is an expanding tick-borne zoonotic disease that may cause severe symptoms and death in elderly or immunocompromised individuals. In light of an increasing resistance of B. microti to drugs, there is a lack of therapeutic alternatives. Species-specific proteases are essential for parasite survival and possible chemotherapeutic targets. However, the repertoire of proteases in B. [ver mas...]
Human babesiosis caused by the intraerythrocytic apicomplexan Babesia microti is an expanding tick-borne zoonotic disease that may cause severe symptoms and death in elderly or immunocompromised individuals. In light of an increasing resistance of B. microti to drugs, there is a lack of therapeutic alternatives. Species-specific proteases are essential for parasite survival and possible chemotherapeutic targets. However, the repertoire of proteases in B. microti remains poorly investigated. Herein, we employed several combined bioinformatics tools and strategies to organize and identify genes encoding for the full repertoire of proteases in the B. microti genome. We identified 64 active proteases and 25 nonactive protease homologs. These proteases can be classified into cysteine (n = 28), serine (n = 21), threonine (n = 14), asparagine (n = 7), and metallopeptidases (n = 19), which, in turn, are assigned to a total of 38 peptidase families. Comparative studies between the repertoire of B. bovis and B. microti proteases revealed differences among sensu stricto and sensu lato Babesia parasites that reflect their distinct evolutionary history. Overall, this data may help direct future research towards our understanding of the biology and pathogenicity of Babesia parasites and to explore proteases as targets for developing novel therapeutic interventions. [Cerrar]
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Author
Florin-Christensen, Monica;   Wieser, Sara Nathaly;   Suarez, Carlos E.;   Schnittger, Leonhard;  
Fuente
Pathogens 10 (11) : 1457 (2021)
Date
2021-11
Editorial
MDPI
ISSN
2076-0817
URI
http://hdl.handle.net/20.500.12123/12046
https://www.mdpi.com/2076-0817/10/11/1457
DOI
https://doi.org/10.3390/pathogens10111457
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Palabras Claves
Babesia; Babesia microti; Babesiosis; Proteasas; Proteases; Zoonosis; Zoonoses; Enfermedades Humanas; Human Diseases;
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