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Abstract
The composition and structure of fleece variation observedin mammals is a consequence of a strong selective pressure for fiber production after domestication. In sheep, fleece variation discriminates ancestral species carrying a long and hairy fleece from modern domestic sheep (Ovis aries) owning a short and woolly fleece.Here, we report that the “woolly” allele results from the insertion of an antisenseEIF2S2retrogene (calledasEIF2S2)intothe3 0 UTR of [ver mas...]
dc.contributor.authorDemars, Julie
dc.contributor.authorCano, Ema Margarita
dc.contributor.authorDrouilhet, Laurence
dc.contributor.authorPlisson-Petit, Florence
dc.contributor.authorBardou, Philippe
dc.contributor.authorFabre, Stéphane
dc.contributor.authorServin, Bertrand
dc.contributor.authorSarry, Julien
dc.contributor.authorWoloszyn, Florent
dc.contributor.authorMulsant, Philippe
dc.contributor.authorFoulquier, Didier
dc.contributor.authorCarriere, Fabien
dc.contributor.authorAletru, Mathias
dc.contributor.authorRodde, Nathalie
dc.contributor.authorCauet, Stéphane
dc.contributor.authorBouchez, Olivier
dc.contributor.authorPirson, Maarten
dc.contributor.authorTosser-Klopp, Gwenola
dc.contributor.authorAllain, Daniel
dc.date.accessioned2017-08-22T17:11:50Z
dc.date.available2017-08-22T17:11:50Z
dc.date.issued2017-07
dc.identifier.issn1537-1719
dc.identifier.otherhttps://doi.org/10.1093/molbev/msx114
dc.identifier.urihttp://hdl.handle.net/20.500.12123/1007
dc.identifier.urihttps://academic.oup.com/mbe/article/34/7/1722/3091105
dc.description.abstractThe composition and structure of fleece variation observedin mammals is a consequence of a strong selective pressure for fiber production after domestication. In sheep, fleece variation discriminates ancestral species carrying a long and hairy fleece from modern domestic sheep (Ovis aries) owning a short and woolly fleece.Here, we report that the “woolly” allele results from the insertion of an antisenseEIF2S2retrogene (calledasEIF2S2)intothe3 0 UTR of theIRF2BP2 gene leading to an abnormal IRF2BP2 transcript. We provide evidence that this chimeric IRF2BP2/asEIF2S2 messenger 1) targets the genuine sense EIF2S2 RNA and 2) creates a long endogenous double-stranded RNA which alters the expression of both EIF2S2 and IRF2BP2 mRNA. This represents a unique example of a phenotype arising via a RNA-RNA hybrid, itself generated through a retroposition mechanism. Our results bring new insights on the sheep population history thanks to the identification of the molecular origin of an evolutionary phenotypic variation.eng
dc.formatapplication/pdfes_AR
dc.language.isoenges_AR
dc.publisherOxford university presses_AR
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourceMolecular Biology and Evolution 34 (7) : 1722-1729 (July 2017)
dc.subjectGenéticaes_AR
dc.subjectGeneticseng
dc.subjectOvinoses_AR
dc.subjectSheepeng
dc.subjectMutaciónes_AR
dc.subjectMutationeng
dc.titleGenome-wide identification of the mutation uderlying fleece variation and discriminating ancestral hairy species from modern woolly sheepes_AR
dc.typeinfo:ar-repo/semantics/artículoes_AR
dc.typeinfo:eu-repo/semantics/articlees_AR
dc.typeinfo:eu-repo/semantics/publishedVersiones_AR
dc.description.origenInstituto de Genéticaes_AR
dc.description.filFil: Demars, Julie. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
dc.description.filFil: Cano, Ema Margarita. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina
dc.description.filFil: Drouilhet, Laurence. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
dc.description.filFil: Plisson-Petit, Florence. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
dc.description.filFil: Bardou, Philippe. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
dc.description.filFil: Fabre, Stéphane. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
dc.description.filFil: Servin, Bertrand. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
dc.description.filFil: Sarry, Julien. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
dc.description.filFil: Woloszyn, Florent. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
dc.description.filFil: Mulsant, Philippe. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
dc.description.filFil: Foulquier, Didier. Institut National de la Recherche Agronomique; Francia
dc.description.filFil: Carriere, Fabien. Institut National de la Recherche Agronomique; Francia
dc.description.filFil: Aletru, Mathias. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
dc.description.filFil: Rodde, Nathalie. Institut National de la Recherche Agronomique; Francia
dc.description.filFil: Cauet, Stéphane. Institut National de la Recherche Agronomique; Francia
dc.description.filFil: Bouchez, Olivier. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
dc.description.filFil: Pirson, Maarten. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
dc.description.filFil: Tosser-Klopp, Gwenola. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
dc.description.filFil: Allain, Daniel. Université de Toulouse. GenPhySE; Francia. Institut National de la Recherche Agronomique; Francia
dc.subtypecientifico


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